HOME >> BIOLOGY >> NEWS
'Why isn't the neural tube defects rate lower?,' asks March of Dimes

omen have an excessive increase in nerve activity in the sympathetic nervous system. Increased nerve activity in this system causes blood vessels to constrict. An excessive increase may cause hypertension - one of the leading causes of death in women in the United States.

Transdermal estrogen replacement therapy has been shown to decrease nerve activity and blood pressure in female laboratory animals.

"In some female rats, removal of the ovaries leads to an increase in nerve activity and blood pressure. Estrogen replacement in the form of an implant under the skin (the effect of which is similar to transdermal estrogen in humans) reverses this problem," Vongpatanasin said. The 12 study participants randomly received transdermal estrogen replacement therapy for eight weeks, then switched to oral estrogen replacement therapy for eight weeks and a placebo for another eight weeks. The researchers used microelectrodes, which are similar to acupuncture needles, to record sympathetic nerve activity and ambulatory blood pressure readings. The researchers recorded about 50 blood pressure readings during a 24-hour period before and after each eight-week therapy.

In a second portion of the study, the researchers evaluated the effectiveness of intravenous estrogen on blood pressure and sympathetic nerve discharge and found no effect. When given orally, Vongpatanasin said, estrogen is transported to the liver, which converts the most active form of estrogen, called estradiol, into the weakest form of estrogen, called estrone. "In order to have similar blood estradiol levels to those seen with transdermal estrogen, a much higher dose of oral estrogen is needed," she said. "This increases the side effects related to the production of a coagulation protein in the liver, which causes blood clots to form in the legs. Other proteins in the liver may also interfere with the ability of estrogen to reduce blood pressure.

"This s
'"/>

Contact: Michele Kling
mkling@modimes.org
914-997-4613
March of Dimes Birth Defects Foundation
19-Jun-2001


Page: 1 2 3

Related biology news :

1. Two warbler species find the West isnt big enough for both of them
2. Bigger isnt always better--especially if youre a rodent
3. Meow isnt language, but enough to manage humans
4. Caffeine in colas: The Real Thing isnt the taste
5. Knock knock knocking on rhythms neural doors
6. Molecule awakens and maintains neural connections
7. DHEA boosts growth rate of human neural stem cells
8. UC Berkeley scientists detail neural circuit that lets eye detect directional motion
9. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
10. The brain uses the same neural networks to engage in conscious and unconscious learning
11. Astrocytes play starring role in neural stem cell development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... ... Regenative Labs has received approval from the Centers for Medicare & Medicaid ... Wharton’s jelly allografts to be assigned a Q code and be approved for application ... jelly allograft product to be recognized as a 361 HCT/P by CMS regulated under ...
(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. ... awarded by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of ... optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet ...
(Date:7/22/2020)... ... July 21, 2020 , ... USDM ... technology and compliance, announces a new solution to manage regulated workloads on Microsoft ... of their technology stack complies with FDA and global regulations. USDM's new managed ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... ... the early detection and prevention of high-burden diseases, and Centric Consulting, a business ... healthcare organizations to utilize existing data in order to identify and prioritize patients ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research ... to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic ... MA has been using the zebrafish model to investigate the causes of leukaemia ...
(Date:7/1/2020)... ... 2020 , ... MedShift , a leading medical technology ... obstacles created as a result of COVID-19. As a provider at the forefront ... and medical manufacturers by expanding access to device offerings, technology services, and marketing ...
(Date:6/28/2020)... JOSE, Calif. (PRWEB) , ... June 25, 2020 ... ... globe, researchers are racing to develop a vaccine or drug treatment. In an ... Recursion has publicly released the world’s largest imaging dataset portraying therapeutic ...
Breaking Biology Technology:
Cached News: