HOME >> BIOLOGY >> NEWS
Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration

Philadelphia, PA, September 29, 1998 -- Five years ago, Wistar Institute immunologist, Ellen Heber-Katz, Ph.D., and her Wistar research team identified a "healer" mouse capable of regenerating ear tissue. In a paper appearing today in the Proceedings of the National Academy of Sciences, they reveal their latest data on the genetics of the "healer" mouse.

Though still at the basic research stage, the Wistar scientists' findings are expected to have major implications for wound and burn healing, organ replacement, spinal cord regeneration and controlled tissue growth.

Because mice are genetically similar to humans, they are an ideal model for the laboratory study of mammalian regeneration. Prior to Dr. Heber-Katz's discovery of the "healer" mouse, it was possible to study regeneration only in amphibians, which are biologically, genetically and immunologically different from humans.

To collect information about the genetics of wound healing and regeneration, Dr. Heber-Katz and her group cross-bred "healer" mice with non-healers. It appears that, in inbred mice, this type of healing is a heritable trait.

By screening the entire mouse genome, Dr. Heber-Katz's laboratory, working in collaboration with immunogeneticist, Elizabeth Blankenhorn, Ph.D., of the Allegheny University of the Health Sciences, has identified multiple regions on five different chromosomes that appear to be responsible for wound healing and regeneration in mammals.

Although the researchers have not yet identified the precise contents of each locus, or region, one potential gene is a receptor for retinoic acid, known to play a role in developmental processes and the growth of skin. Interestingly, retinoic acid is also involved in amphibian regeneration.

Similar to what has been seen in amphibian regeneration, "healer" mice appear to develop a blastema at the site of a wound. A blastema is a structure made up of rapidly dividing immature cells with the potential to
'"/>

Contact: Diana Cutshall
dcutshall@wista.wistar.upenn.edu
(215) 898-3716
The Wistar Institute
30-Sep-1998


Page: 1 2

Related biology news :

1. Wistar-discovered antibody will help diagnose appendicitis
2. 2004 Wistar Institute Science Journalism Award winners announced
3. Call for Entries: The 2004 Wistar Institute Science Journalism Award
4. Wistar-developed antibody shows promise against brain tumors in Drexel trial
5. Wistar study offers new support for a histone code theory of gene regulation
6. Regeneration in the mammalian heart demonstrated by Wistar researchers
7. Wistar scientists add difficult-to-sequence stretches to human genome data
8. Wistar scientist receives award from National Cancer Institute
9. Director of Emory Vaccine Center to give Wistar Institutes 1999 Tadeusz J. Wiktor Memorial lecture
10. Wistar scientists find striking similarities between bacterial virus and human adenovirus
11. Wistar Institute scientists find key piece in gene regulation puzzle

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... (PRWEB) , ... July 21, 2020 , ... ... digital transformation and innovation in technology and compliance, announces a new solution to ... companies must ensure every layer of their technology stack complies with FDA and ...
(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical (ABM), a ... awards for not only the products and treatments developed, but also the dedicated ... RF. All the brands built by ABM have received several honors already for ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... R&D, today announced that it has entered into a multi-year contract with ... to support their translational and clinical research strategy to discover and develop ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... Texas (PRWEB) , ... August 06, 2020 , ... ... and DNA vaccine industries, announces it has closed on the purchase of greenfield ... Park in Conroe, TX and includes over 21 acres in the initial acquisition, ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified ... systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... one or two switches in a push-pull configuration; yielding fast fall time for ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra ... life sciences and food industries, is pleased to announce that Charles Galea has ... Business Development. , Charles is an accomplished and results-driven sales executive with over ...
Breaking Biology Technology:
Cached News: