HOME >> BIOLOGY >> NEWS
Wistar scientists add difficult-to-sequence stretches to human genome data

Philadelphia - In a new study, researchers at The Wistar Institute report extending the working draft sequence of the human genome to reach most of the tips of human chromosomes, called telomeres. The telomeres and adjacent regions were not fully included in the working draft sequence announced last summer because they have unique properties that make them particularly difficult to isolate and analyze.

In addition, the Wistar researchers found that the adjacent, or subtelomeric regions, appear to display more variation from individual to individual than other parts of the genome. They also reported that the subtelomeric regions are gene-rich, suggesting that these areas may serve essential functions and are not simply buffers of nonfunctional "junk DNA" next to the telomere, as some have thought.

Their study was published in the February 15 Nature, a special issue focusing on the Human Genome Project in which the publicly funded International Human Genome Sequencing Consortium's working draft sequence is published.

"Telomeres and subtelomeric regions make up less than 1 percent of the human genome, but they're quite important," says Harold C. Riethman, Ph.D., lead author on the study and associate professor at The Wistar Institute. "When the cellular machinery that maintains telomeres becomes damaged, a cell fails to divide properly, which is one of the hallmarks of cancer."

In addition to cell division, telomeric DNA mediates many important biological activities, such as cellular aging, movement and localization of chromosomes within the nucleus, and transcriptional regulation of subtelomeric genes.

To analyze the telomeric regions, the researchers developed a specialized yeast cloning vehicle-called half-YAC, or half-yeast artificial chromosome-to produce copies of human DNA regions linked to telomeres. Cloning, or making copies of, DNA is an important step in genomic sequencing. The working draft sequence was produced using a bacteria
'"/>

Contact: Marion Wyce
wyce@wistar.upenn.edu
215-898-3943
The Wistar Institute
10-Feb-2001


Page: 1 2 3

Related biology news :

1. Wistar-discovered antibody will help diagnose appendicitis
2. 2004 Wistar Institute Science Journalism Award winners announced
3. Call for Entries: The 2004 Wistar Institute Science Journalism Award
4. Wistar-developed antibody shows promise against brain tumors in Drexel trial
5. Wistar study offers new support for a histone code theory of gene regulation
6. Regeneration in the mammalian heart demonstrated by Wistar researchers
7. Wistar scientist receives award from National Cancer Institute
8. Director of Emory Vaccine Center to give Wistar Institutes 1999 Tadeusz J. Wiktor Memorial lecture
9. Wistar scientists find striking similarities between bacterial virus and human adenovirus
10. Wistar Institute scientists find key piece in gene regulation puzzle
11. Wistar immunologists awarded grants to promote the development of vaccinesagainst HIV-1 and human papilloma viruses

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: