HOME >> BIOLOGY >> NEWS
Wistar scientists add difficult-to-sequence stretches to human genome data

Philadelphia - In a new study, researchers at The Wistar Institute report extending the working draft sequence of the human genome to reach most of the tips of human chromosomes, called telomeres. The telomeres and adjacent regions were not fully included in the working draft sequence announced last summer because they have unique properties that make them particularly difficult to isolate and analyze.

In addition, the Wistar researchers found that the adjacent, or subtelomeric regions, appear to display more variation from individual to individual than other parts of the genome. They also reported that the subtelomeric regions are gene-rich, suggesting that these areas may serve essential functions and are not simply buffers of nonfunctional "junk DNA" next to the telomere, as some have thought.

Their study was published in the February 15 Nature, a special issue focusing on the Human Genome Project in which the publicly funded International Human Genome Sequencing Consortium's working draft sequence is published.

"Telomeres and subtelomeric regions make up less than 1 percent of the human genome, but they're quite important," says Harold C. Riethman, Ph.D., lead author on the study and associate professor at The Wistar Institute. "When the cellular machinery that maintains telomeres becomes damaged, a cell fails to divide properly, which is one of the hallmarks of cancer."

In addition to cell division, telomeric DNA mediates many important biological activities, such as cellular aging, movement and localization of chromosomes within the nucleus, and transcriptional regulation of subtelomeric genes.

To analyze the telomeric regions, the researchers developed a specialized yeast cloning vehicle-called half-YAC, or half-yeast artificial chromosome-to produce copies of human DNA regions linked to telomeres. Cloning, or making copies of, DNA is an important step in genomic sequencing. The working draft sequence was produced using a bacteria
'"/>

Contact: Marion Wyce
wyce@wistar.upenn.edu
215-898-3943
The Wistar Institute
10-Feb-2001


Page: 1 2 3

Related biology news :

1. Wistar-discovered antibody will help diagnose appendicitis
2. 2004 Wistar Institute Science Journalism Award winners announced
3. Call for Entries: The 2004 Wistar Institute Science Journalism Award
4. Wistar-developed antibody shows promise against brain tumors in Drexel trial
5. Wistar study offers new support for a histone code theory of gene regulation
6. Regeneration in the mammalian heart demonstrated by Wistar researchers
7. Wistar scientist receives award from National Cancer Institute
8. Director of Emory Vaccine Center to give Wistar Institutes 1999 Tadeusz J. Wiktor Memorial lecture
9. Wistar scientists find striking similarities between bacterial virus and human adenovirus
10. Wistar Institute scientists find key piece in gene regulation puzzle
11. Wistar immunologists awarded grants to promote the development of vaccinesagainst HIV-1 and human papilloma viruses

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... ... 2019 , ... Hello Bio announces the launch of novel ... studying GPCR and DREADD signalling. Hello Bio has been granted a license from ... and Stroke, both institutes of the National Institutes of Health, as well as ...
(Date:2/27/2019)... ... February 26, 2019 , ... Circulomics is launching the ... (HMW) DNA for long-read sequencing library preparation. , This kit enhances long-read sequencing ... ensures that HMW DNA is not damaged and recovered with high efficiency. Short DNA ...
(Date:2/22/2019)... (PRWEB) , ... February 21, 2019 , ... X-ray analytical ... 54th annual meeting of the Texas Society for Microscopy ( TSM ). The event ... San Antonio and takes place February 21st - 23rd, 2019. Several workshops are scheduled, ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... ... The growth in the number and complexity of regulations as well as ... intelligence (RI) systems are not keeping with ... and cheaper. With a diversity of information sources, identifying and analyzing context based intelligence ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... that its Canadian partner, the Eye Machine Canada Inc., had been given approval ... technology for treating Age-Related Macular Degeneration (AMD). , The previous month, the medical ...
(Date:3/14/2019)... Md. (PRWEB) , ... March 13, 2019 , ... ... announced its 2019 ISPE Europe Biotechnology Conference , taking place in Brussels, ... sharing biotechnology best practices, technical and operational solutions, and innovative approaches. , ...
(Date:3/12/2019)... ... March 11, 2019 , ... Centura Health, ... and among the first in the nation, to offer needle-free blood draws for ... and overall degree to which staff showed compassion jumped up by an average ...
Breaking Biology Technology:
Cached News: