Wistar study offers new support for a 'histone code' theory of gene regulation

PHILADELPHIA - A new study by researchers at The Wistar Institute provides important experimental data to support a novel theory of gene regulation. The theory holds that coordinated patterns of modifications to DNA-packaging proteins called histones may be a key factor in turning specific genes on or off.

The proposed system of gene control has been termed a kind of "histone code" by one researcher and may govern most gene activity. Understanding the system could well prove crucial to researchers exploring cancer, developmental disorders, and other disease processes that hinge on gene control gone awry.

In their study, the Wistar scientists identified an enzyme that works in concert with another enzyme to modify a histone, triggering the transcription of a particular gene in yeast. The findings represent one of the first times that two modifications of a histone, one dependent on the other, have been shown to be necessary for a gene's activation. A report on the work appears in the August 10 issue of Science.

"The linking of this pair of histone modifications to the transcription of a gene strongly supports the notion that a kind of intricate interplay among such alterations - a code, if you will - may be controlling the greater part of gene activity," says Shelley L. Berger, Ph.D., an associate professor and senior author on the study. "Scientists are just beginning to explore this system of gene regulation. Already, however, it looks as though it may of comparable importance to the discovery some years ago of activator and repressor molecules that bind directly to DNA to turn genes on or off."

Estimates are that only a tenth of all human genes are expressed at any given time. Most of the time, the great majority of genes are silenced, locked away within a complex packaging scheme of proteins called chromatin. For a given gene to be activated when needed, the chromatin must be opened at that location on the DNA, and that location o

Contact: Franklin Hoke
The Wistar Institute

Page: 1 2

Related biology news :

1. Wistar-discovered antibody will help diagnose appendicitis
2. 2004 Wistar Institute Science Journalism Award winners announced
3. Call for Entries: The 2004 Wistar Institute Science Journalism Award
4. Wistar-developed antibody shows promise against brain tumors in Drexel trial
5. Regeneration in the mammalian heart demonstrated by Wistar researchers
6. Wistar scientists add difficult-to-sequence stretches to human genome data
7. Wistar scientist receives award from National Cancer Institute
8. Director of Emory Vaccine Center to give Wistar Institutes 1999 Tadeusz J. Wiktor Memorial lecture
9. Wistar scientists find striking similarities between bacterial virus and human adenovirus
10. Wistar Institute scientists find key piece in gene regulation puzzle
11. Wistar immunologists awarded grants to promote the development of vaccinesagainst HIV-1 and human papilloma viruses

Post Your Comments:

(Date:6/11/2020)... ... 2020 , ... Cryo-Cell International’s announcement comes on the heel ... the medical field. The face masks will be distributed nationwide to obstetrical and ... to provide healthcare to pregnant women. The delivery of masks is scheduled to ...
(Date:6/5/2020)... ... June 04, 2020 , ... Murrieta Genomics has announced that ... for simplified sample preparation for Next Generation Genomic Sequencing (NGS) . This is ... and complexity of sample preparation. , “I have been at the bench for over ...
(Date:6/5/2020)... ... June 04, 2020 , ... Greffex, a pioneering vaccine and gene ... Directors. , “Neil understands the need for a global perspective to make an impact ... Greffex. Mr. Bush will serve as an independent, director of the company. , “The ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... Kerafast Inc. , ... today announced the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. ... studies of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., ... presented June 22-24 during the American Association for Cancer Research Virtual meeting. One ... the potent, consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
(Date:6/11/2020)... ... , ... Greffex, a leading genetic engineering company, with the ... vectors, recently announced a key manufacturing agreement with FUJIFILM Diosynth Biotechnologies to produce ... successful gene therapy delivery vehicle (vector) with broad applications for delivering treatments including ...
(Date:6/11/2020)... ... June 09, 2020 , ... Reducing carbon emissions has been and will continue ... to stock market dips, ways to reduce CO2 is something we can’t avoid. ... of the biofuels being produced today are created from recycled cooking oil or crops. ...
Breaking Biology Technology:
Cached News: