Wistar study offers new support for a 'histone code' theory of gene regulation

PHILADELPHIA - A new study by researchers at The Wistar Institute provides important experimental data to support a novel theory of gene regulation. The theory holds that coordinated patterns of modifications to DNA-packaging proteins called histones may be a key factor in turning specific genes on or off.

The proposed system of gene control has been termed a kind of "histone code" by one researcher and may govern most gene activity. Understanding the system could well prove crucial to researchers exploring cancer, developmental disorders, and other disease processes that hinge on gene control gone awry.

In their study, the Wistar scientists identified an enzyme that works in concert with another enzyme to modify a histone, triggering the transcription of a particular gene in yeast. The findings represent one of the first times that two modifications of a histone, one dependent on the other, have been shown to be necessary for a gene's activation. A report on the work appears in the August 10 issue of Science.

"The linking of this pair of histone modifications to the transcription of a gene strongly supports the notion that a kind of intricate interplay among such alterations - a code, if you will - may be controlling the greater part of gene activity," says Shelley L. Berger, Ph.D., an associate professor and senior author on the study. "Scientists are just beginning to explore this system of gene regulation. Already, however, it looks as though it may of comparable importance to the discovery some years ago of activator and repressor molecules that bind directly to DNA to turn genes on or off."

Estimates are that only a tenth of all human genes are expressed at any given time. Most of the time, the great majority of genes are silenced, locked away within a complex packaging scheme of proteins called chromatin. For a given gene to be activated when needed, the chromatin must be opened at that location on the DNA, and that location o

Contact: Franklin Hoke
The Wistar Institute

Page: 1 2

Related biology news :

1. Wistar-discovered antibody will help diagnose appendicitis
2. 2004 Wistar Institute Science Journalism Award winners announced
3. Call for Entries: The 2004 Wistar Institute Science Journalism Award
4. Wistar-developed antibody shows promise against brain tumors in Drexel trial
5. Regeneration in the mammalian heart demonstrated by Wistar researchers
6. Wistar scientists add difficult-to-sequence stretches to human genome data
7. Wistar scientist receives award from National Cancer Institute
8. Director of Emory Vaccine Center to give Wistar Institutes 1999 Tadeusz J. Wiktor Memorial lecture
9. Wistar scientists find striking similarities between bacterial virus and human adenovirus
10. Wistar Institute scientists find key piece in gene regulation puzzle
11. Wistar immunologists awarded grants to promote the development of vaccinesagainst HIV-1 and human papilloma viruses

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: