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Wistar study offers new support for a 'histone code' theory of gene regulation

nly, to make the gene physically accessible for transcription. Histone proteins are one of the key components of chromatin structure.

Histones are relatively small proteins around which DNA coils itself to create structures called nucleosomes. Compact strings of nucleosomes, then, form into chromatin, a substructure of chromosomes, of which humans have 23 pairs in the nucleus of every cell. When the DNA is tightly wrapped around the histones, the genes cannot be accessed and their expression is repressed. When the coils of DNA around the histones are loosened, the genes become available for expression. The "histone code" theory of gene regulation, recently articulated by C. David Allis, Ph.D., at the University of Virginia, and others suggests that complex, interdependent modifications to the histones are responsible for controlling gene activity. The new data from the Wistar research team supports this idea.


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Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
9-Aug-2001


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