HOME >> BIOLOGY >> NEWS
Women Who Smoke While Pregnant Pass Along Genetic Mutations To Their Babies, According To Pitt Researchers

Certain mothers who smoke while pregnant are at high risk of passing along genetic damage to their babies, according to study results presented by University of Pittsburgh scientists at the annual American Association for Cancer Research meeting in New Orleans.

"This type of damage is dangerous for pregnant women, and we believe it could also put newborns at an increased risk of cancer," said Marjorie Romkes, Ph.D., assistant professor of environmental and occupational health at the University of Pittsburgh Graduate School of Public Health.

Dr. Romkes is a member of a team of scientists who monitored 290 smoking expectant mothers and nonsmoking pregnant women in an ongoing study evaluating a number of biomarkers of tobacco exposure, genetic susceptibility to cancer and early biological effects of cancer-causing agents. They studied the incidence of mutations in the gene for glycophorin A (GPA), a molecule found in the membrane of red blood cells. Changes in the GPA gene are considered a measure of genetic damage in non-reproductive cells of the body. The scientists also studied various metabolic enzymes that process chemicals found in tobacco smoke.

"We found 18 expectant mothers who had very high frequencies of GPA mutations. A baby born to one of these mothers who was a heavy smoker also had these mutations," said Dr. Romkes. "In addition, among these women with significantly elevated GPA mutation frequencies, each mother was a carrier of at least two 'at-risk' enzyme genotypes."

"At-risk" genotypes are defined as variations in the genes coding for metabolic enzymes, resulting in increased activation or decreased detoxification of cancer-causing toxins.

The researchers also found that as women smoked more heavily, the levels of some of these enzymes (CYP1A1 and CYP2E1) increased. CYP1A1 and CYP2E1 transform substances in tobacco smoke into dangerous carcinogens that cause cellular
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
31-Mar-1998


Page: 1 2

Related biology news :

1. Women who have donated eggs sought for national study
2. Donaghue Womens Health Investigator Program awards grants to three at Yale
3. Top Houston Women in Technology honoree at UH
4. Marie Curie Nobel Centennial Celebration of Women in Science
5. Victoria Hale of Institute for OneWorld Health Named Fellow by International Womens Forum
6. Women who drink may be at greater risk of cardiovascular complications than men
7. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
8. Women are more likely to suffer recurrent miscarriages if their first child is a boy
9. Womens health issues, child and adolescent disorders featured at APAs annual meeting
10. Women who marry alcoholics
11. Pregnancy hormone induces healthy blood vessels, Magee-Womens Research Institute scientists report

Post Your Comments:
(Date:7/21/2014)... have meaning? If you say "dog" to a friend, ... University philosopher Elliott Wagner aims to address these types ... long-standing philosophical questions about semantic meaning. Wagner, assistant professor ... are collaborating to use game theory to analyze communication ... a cappuccino at a coffee shop, I usually don,t ...
(Date:7/21/2014)... to climate change, due to greenhouse gasses emitted by ... the rise and that beef cattle are responsible for ... animals. It is published by Climactic Change . ... it comes to climate change. It is released by ... portion of greenhouse gas totals. But methane and nitrous ...
(Date:7/21/2014)... the strength of immune response, rather than with the ... the virus, might be a better way to reduce ... Washington, Seattle. She and her collaborators have now taken ... H7N9 influenza, and their work has already led to ... strain. The research is published ahead of print in ...
Breaking Biology News(10 mins):Philosopher uses game theory to understand how words, actions acquire meaning 2Climate: Meat turns up the heat 2Potential new flu drugs target immune response, not virus 2
(Date:7/18/2014)... N.Y. , July 18, 2014 Regeneron ... its second quarter 2014 financial and operating results on ... open.  The Company will host a conference call and ... Conference Call InformationTo access this call, ... link to the webcast may be accessed from the ...
(Date:7/18/2014)... is, most of the atoms in our environment are ... outer parts of atoms equals the number of protons ... more electrons are plucked away from the atoms, the ... the nucleus. This enhanced pull, causing the atoms ... less vulnerable to the distractions of their environment, making ...
(Date:7/18/2014)... (PRWEB) July 18, 2014 Global ... with US offices in Cambridge, MA, announces the ... Assay and Software product that leverages the power ... the Illumina® MiSeq sequencing platform. The assay and ... Children’s Hospital of Philadelphia (CHOP) and will include ...
(Date:7/18/2014)... 18, 2014 The International Wheat Genome Sequencing ... a draft sequence of the bread wheat genome. The ... and evolution of the large, complex genome of the ... genetic blueprint is an invaluable resource to plant science ... at their disposal a set of tools enabling them ...
Breaking Biology Technology:Highly charged ions 2Highly charged ions 3Highly charged ions 4Omixon Launches Holotype HLA for NGS-based HLA Genotyping 2Omixon Launches Holotype HLA for NGS-based HLA Genotyping 3Genetic Blueprint of Bread Wheat Genome Unveiled 2Genetic Blueprint of Bread Wheat Genome Unveiled 3
Cached News: