HOME >> BIOLOGY >> NEWS
Women Who Smoke While Pregnant Pass Along Genetic Mutations To Their Babies, According To Pitt Researchers

Certain mothers who smoke while pregnant are at high risk of passing along genetic damage to their babies, according to study results presented by University of Pittsburgh scientists at the annual American Association for Cancer Research meeting in New Orleans.

"This type of damage is dangerous for pregnant women, and we believe it could also put newborns at an increased risk of cancer," said Marjorie Romkes, Ph.D., assistant professor of environmental and occupational health at the University of Pittsburgh Graduate School of Public Health.

Dr. Romkes is a member of a team of scientists who monitored 290 smoking expectant mothers and nonsmoking pregnant women in an ongoing study evaluating a number of biomarkers of tobacco exposure, genetic susceptibility to cancer and early biological effects of cancer-causing agents. They studied the incidence of mutations in the gene for glycophorin A (GPA), a molecule found in the membrane of red blood cells. Changes in the GPA gene are considered a measure of genetic damage in non-reproductive cells of the body. The scientists also studied various metabolic enzymes that process chemicals found in tobacco smoke.

"We found 18 expectant mothers who had very high frequencies of GPA mutations. A baby born to one of these mothers who was a heavy smoker also had these mutations," said Dr. Romkes. "In addition, among these women with significantly elevated GPA mutation frequencies, each mother was a carrier of at least two 'at-risk' enzyme genotypes."

"At-risk" genotypes are defined as variations in the genes coding for metabolic enzymes, resulting in increased activation or decreased detoxification of cancer-causing toxins.

The researchers also found that as women smoked more heavily, the levels of some of these enzymes (CYP1A1 and CYP2E1) increased. CYP1A1 and CYP2E1 transform substances in tobacco smoke into dangerous carcinogens that cause cellular
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
31-Mar-1998


Page: 1 2

Related biology news :

1. Women who have donated eggs sought for national study
2. Donaghue Womens Health Investigator Program awards grants to three at Yale
3. Top Houston Women in Technology honoree at UH
4. Marie Curie Nobel Centennial Celebration of Women in Science
5. Victoria Hale of Institute for OneWorld Health Named Fellow by International Womens Forum
6. Women who drink may be at greater risk of cardiovascular complications than men
7. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
8. Women are more likely to suffer recurrent miscarriages if their first child is a boy
9. Womens health issues, child and adolescent disorders featured at APAs annual meeting
10. Women who marry alcoholics
11. Pregnancy hormone induces healthy blood vessels, Magee-Womens Research Institute scientists report

Post Your Comments:
(Date:12/10/2014)... DUBLIN , Dec. 08, 2014 Research ... announced the addition of the "Biometrics Market ... http://photos.prnewswire.com/prnh/20130307/600769 ... for projects such as rural banking and upgradation ... major trends witnessed in the market. Besides the ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin Test ... innovative test solutions for military, aerospace, and manufacturing ... of its successful TS-900 PXI semiconductor test ... features of high-end systems to customers at a ... compared to traditional ATE. "Our ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, a ... Internet of Things (IoT), today announced the appointment of ... operating officer. Previously a strategic advisor to the firm, ... operations. Mr. Traynor is based out of the C-Labs ... reports to Chris Muench , Chief Executive Officer. ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the ... Maroulis, Pharm.D. to the newly created position of Vice ... position, Dr. Maroulis will continue to manage the entire ... multi-site pharmacies as the company expands. Dr. Maroulis has ... he has served in many different capacities in the ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources ... will grow at a 12 percent compound annual growth ... of the aging population and the increasing adoption of ... America will also spur demand for dental ... dental implant and periodontal treatments. Other key ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 LayerBio is ... ophthalmology and wound care. The National Eye Institute (NEI) ... LayerBio a Phase I SBIR grant to develop a ... are the most common cause of vision loss in ... blindness worldwide. According to Dr. Ken Mandell, LayerBio’s Founder ...
(Date:12/19/2014)... In contrast to traditional LED lights ... colors, Valoya uses proprietary LED technology to incorporate their ... uniformity which is critical in low proximity installations. The ... throughout its lifetime which is up to four times ... "The investment cost was clearly higher when compared to ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
Cached News: