HOME >> BIOLOGY >> NEWS
Women Who Smoke While Pregnant Pass Along Genetic Mutations To Their Babies, According To Pitt Researchers

Certain mothers who smoke while pregnant are at high risk of passing along genetic damage to their babies, according to study results presented by University of Pittsburgh scientists at the annual American Association for Cancer Research meeting in New Orleans.

"This type of damage is dangerous for pregnant women, and we believe it could also put newborns at an increased risk of cancer," said Marjorie Romkes, Ph.D., assistant professor of environmental and occupational health at the University of Pittsburgh Graduate School of Public Health.

Dr. Romkes is a member of a team of scientists who monitored 290 smoking expectant mothers and nonsmoking pregnant women in an ongoing study evaluating a number of biomarkers of tobacco exposure, genetic susceptibility to cancer and early biological effects of cancer-causing agents. They studied the incidence of mutations in the gene for glycophorin A (GPA), a molecule found in the membrane of red blood cells. Changes in the GPA gene are considered a measure of genetic damage in non-reproductive cells of the body. The scientists also studied various metabolic enzymes that process chemicals found in tobacco smoke.

"We found 18 expectant mothers who had very high frequencies of GPA mutations. A baby born to one of these mothers who was a heavy smoker also had these mutations," said Dr. Romkes. "In addition, among these women with significantly elevated GPA mutation frequencies, each mother was a carrier of at least two 'at-risk' enzyme genotypes."

"At-risk" genotypes are defined as variations in the genes coding for metabolic enzymes, resulting in increased activation or decreased detoxification of cancer-causing toxins.

The researchers also found that as women smoked more heavily, the levels of some of these enzymes (CYP1A1 and CYP2E1) increased. CYP1A1 and CYP2E1 transform substances in tobacco smoke into dangerous carcinogens that cause cellular
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
31-Mar-1998


Page: 1 2

Related biology news :

1. Women who have donated eggs sought for national study
2. Donaghue Womens Health Investigator Program awards grants to three at Yale
3. Top Houston Women in Technology honoree at UH
4. Marie Curie Nobel Centennial Celebration of Women in Science
5. Victoria Hale of Institute for OneWorld Health Named Fellow by International Womens Forum
6. Women who drink may be at greater risk of cardiovascular complications than men
7. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
8. Women are more likely to suffer recurrent miscarriages if their first child is a boy
9. Womens health issues, child and adolescent disorders featured at APAs annual meeting
10. Women who marry alcoholics
11. Pregnancy hormone induces healthy blood vessels, Magee-Womens Research Institute scientists report

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... L3 Clinical ... announce the company is now a certified iMedNet eClinical and Electronic Data Capture ... the company’s clinical research team to build, customize and manage clinical trial data ...
(Date:4/25/2017)... ... April 25, 2017 , ... Dr. Robert ... P.A. , proudly announced today that acclaimed physiatrist Matthew Terzella, MD, has joined ... 15, 2017. , Dr. Terzella completed his residency in Physical Medicine and Rehabilitation ...
(Date:4/25/2017)... SEATTLE, WA (PRWEB) , ... April 25, 2017 , ... ... technology division of Quorum, will be featured in multiple sessions at this week’s ... range from emerging trends to best practices in clinical research. , "We are excited ...
(Date:4/24/2017)... April 24, 2017  Dante Labs announced today the offer ... 850 (ca. $900). While American individuals have been able to ... Europeans can access WGS below EUR 1,000. The ... leveraging genetic information to make informed decisions about disease monitoring, ... ...
Breaking Biology Technology:
Cached News: