HOME >> BIOLOGY >> NEWS
Women Who Smoke While Pregnant Pass Along Genetic Mutations To Their Babies, According To Pitt Researchers

Certain mothers who smoke while pregnant are at high risk of passing along genetic damage to their babies, according to study results presented by University of Pittsburgh scientists at the annual American Association for Cancer Research meeting in New Orleans.

"This type of damage is dangerous for pregnant women, and we believe it could also put newborns at an increased risk of cancer," said Marjorie Romkes, Ph.D., assistant professor of environmental and occupational health at the University of Pittsburgh Graduate School of Public Health.

Dr. Romkes is a member of a team of scientists who monitored 290 smoking expectant mothers and nonsmoking pregnant women in an ongoing study evaluating a number of biomarkers of tobacco exposure, genetic susceptibility to cancer and early biological effects of cancer-causing agents. They studied the incidence of mutations in the gene for glycophorin A (GPA), a molecule found in the membrane of red blood cells. Changes in the GPA gene are considered a measure of genetic damage in non-reproductive cells of the body. The scientists also studied various metabolic enzymes that process chemicals found in tobacco smoke.

"We found 18 expectant mothers who had very high frequencies of GPA mutations. A baby born to one of these mothers who was a heavy smoker also had these mutations," said Dr. Romkes. "In addition, among these women with significantly elevated GPA mutation frequencies, each mother was a carrier of at least two 'at-risk' enzyme genotypes."

"At-risk" genotypes are defined as variations in the genes coding for metabolic enzymes, resulting in increased activation or decreased detoxification of cancer-causing toxins.

The researchers also found that as women smoked more heavily, the levels of some of these enzymes (CYP1A1 and CYP2E1) increased. CYP1A1 and CYP2E1 transform substances in tobacco smoke into dangerous carcinogens that cause cellular
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
31-Mar-1998


Page: 1 2

Related biology news :

1. Women who have donated eggs sought for national study
2. Donaghue Womens Health Investigator Program awards grants to three at Yale
3. Top Houston Women in Technology honoree at UH
4. Marie Curie Nobel Centennial Celebration of Women in Science
5. Victoria Hale of Institute for OneWorld Health Named Fellow by International Womens Forum
6. Women who drink may be at greater risk of cardiovascular complications than men
7. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
8. Women are more likely to suffer recurrent miscarriages if their first child is a boy
9. Womens health issues, child and adolescent disorders featured at APAs annual meeting
10. Women who marry alcoholics
11. Pregnancy hormone induces healthy blood vessels, Magee-Womens Research Institute scientists report

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2016)... 2016 Securus Technologies, a leading provider of ... investigation, corrections and monitoring, announced today that it has ... have an independent technology judge determine who has the ... tech/sophisticated telephone calling platform, and the best customer service. ... most of what we do – which clearly is ...
(Date:11/15/2016)... -- Research and Markets has announced the addition of ... to their offering. ... The global bioinformatics ... USD 6.21 Billion in 2016, growing at a CAGR of 21.1% ... market is driven by the growing demand for nucleic acid and ...
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... , ... December 06, 2016 ... ... Great Point Partners ("GPP") portfolio company, today announced it has acquired the ... a subsidiary of Chiltern International and focuses on clinical trial drug packaging, ...
(Date:12/6/2016)... Ind. , Dec. 6, 2016 Zimmer ... "Company") today announced the pricing terms of its ... to $1.25 billion aggregate purchase price (excluding accrued and ... settlement date and excluding fees and expenses related ... the debt securities identified in the table below ...
(Date:12/6/2016)... Toronto, ON (PRWEB) , ... ... ... (“ProMIS” or the “Company”), a company focused on discovery and development of ... therapeutic candidates it is developing for Alzheimer’s disease (AD) inhibited the direct ...
(Date:12/5/2016)... ... December 05, 2016 , ... This composition patent, U.S. Patent ... The composition claims are not limited to any particular process to make ... polymers, carbon fibers, graphene, and other materials. A continuation application, U.S. Patent ...
Breaking Biology Technology:
Cached News: