HOME >> BIOLOGY >> NEWS
Women Who Smoke While Pregnant Pass Along Genetic Mutations To Their Babies, According To Pitt Researchers

Certain mothers who smoke while pregnant are at high risk of passing along genetic damage to their babies, according to study results presented by University of Pittsburgh scientists at the annual American Association for Cancer Research meeting in New Orleans.

"This type of damage is dangerous for pregnant women, and we believe it could also put newborns at an increased risk of cancer," said Marjorie Romkes, Ph.D., assistant professor of environmental and occupational health at the University of Pittsburgh Graduate School of Public Health.

Dr. Romkes is a member of a team of scientists who monitored 290 smoking expectant mothers and nonsmoking pregnant women in an ongoing study evaluating a number of biomarkers of tobacco exposure, genetic susceptibility to cancer and early biological effects of cancer-causing agents. They studied the incidence of mutations in the gene for glycophorin A (GPA), a molecule found in the membrane of red blood cells. Changes in the GPA gene are considered a measure of genetic damage in non-reproductive cells of the body. The scientists also studied various metabolic enzymes that process chemicals found in tobacco smoke.

"We found 18 expectant mothers who had very high frequencies of GPA mutations. A baby born to one of these mothers who was a heavy smoker also had these mutations," said Dr. Romkes. "In addition, among these women with significantly elevated GPA mutation frequencies, each mother was a carrier of at least two 'at-risk' enzyme genotypes."

"At-risk" genotypes are defined as variations in the genes coding for metabolic enzymes, resulting in increased activation or decreased detoxification of cancer-causing toxins.

The researchers also found that as women smoked more heavily, the levels of some of these enzymes (CYP1A1 and CYP2E1) increased. CYP1A1 and CYP2E1 transform substances in tobacco smoke into dangerous carcinogens that cause cellular
'"/>

Contact: Lauren Ward
wardla@a1.isd.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
31-Mar-1998


Page: 1 2

Related biology news :

1. Women who have donated eggs sought for national study
2. Donaghue Womens Health Investigator Program awards grants to three at Yale
3. Top Houston Women in Technology honoree at UH
4. Marie Curie Nobel Centennial Celebration of Women in Science
5. Victoria Hale of Institute for OneWorld Health Named Fellow by International Womens Forum
6. Women who drink may be at greater risk of cardiovascular complications than men
7. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
8. Women are more likely to suffer recurrent miscarriages if their first child is a boy
9. Womens health issues, child and adolescent disorders featured at APAs annual meeting
10. Women who marry alcoholics
11. Pregnancy hormone induces healthy blood vessels, Magee-Womens Research Institute scientists report

Post Your Comments:
(Date:7/31/2015)... SHENZHEN , Kina, 31. juli 2015 ... ) bliver afholdt af BGI fra den 22. - 25. ... Konferencen fejrer sin 10-års fødselsdag i år. ... verdens mest indflydelsesrige årlige møder på ,omik,-feltet, og er ... forsamlinger. ICG-10 fokuserer på nylige gennembrud ...
(Date:7/31/2015)... de 2015 A 10 a. Conferência ... pela BGI de 22-25 de outubro de 2015, em ... conferência está celebrando seu 10 o. aniversário este ano. ... uma das reuniões mais influentes do mundo no ramo ... entusiastas e prazerosos. A ICG-10 se ...
(Date:7/31/2015)... de julio de 2015 La 10 th ... por medio de BGI del 22 al 25 de octubre de ... Este año, la conferencia celebra su décimo aniversario. Desde ... en una de las reuniones anuales más influyentes del mundo ... reuniones más dinámicas, entusiastas y mejores a nivel científico. ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3
(Date:8/4/2015)... PORTLAND, Oregon , August 4, 2015 /PRNewswire/ ... published by Allied Market Research, titled, "World Cardiac ... global cardiac biomarker market would generate the revenue ... of 18.9% from 2015 to 2020. Cardiac Troponins ... throughout the forecast period due to high sensitivity ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... rapid point-of-care (POC) diagnostic tests – today announced that Robert A. Gregg, PhD, ... Gregg has more than 30 years of relevant experience and remarkable achievements in ...
(Date:8/4/2015)... -- Blueprint Medicines (NASDAQ: BPMC ), a leader in ... defined diseases, today announced that Jeffrey Albers , ... the 2015 Wedbush PacGrow Healthcare Conference on Tuesday, August ... live webcast of the event will be available by ... at www.blueprintmedicines.com . An archived replay of the ...
(Date:8/4/2015)... ... 04, 2015 , ... On August 4, 2015, the White House will host ... across the United States to talk about their experiences with innovation and present their ... be among the attendees. , One of the day’s aims is to grow the ...
Breaking Biology Technology:Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 2Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 3Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 4Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 5RPS Diagnostics Welcomes Robert Gregg as Senior Vice President of Clinical and Regulatory Affairs 2RPS Diagnostics Welcomes Robert Gregg as Senior Vice President of Clinical and Regulatory Affairs 3White House Invites uBiome CEO Jessica Richman to First-Ever Startup Demo Day 2
Cached News: