HOME >> BIOLOGY >> NEWS
Wonder Thread: UD Scientists Report First Protein With Collagen And Elastin-Like Domains

take advantage of their remarkable properties, says Harold Slavkin, director of the National Institute of Dental Research, one of the National Institutes of Health, which sponsored the UD study. "Insight into the molecular structure that makes the byssus strong yet flexible might suggest, for example, new strategies for designing more comfortable and pliable artificial skin," Slavkin says.

Curious Forms of Collagen

To find out what makes byssal threads so special, Qin and Waite first isolated two key collagens: Col-P and Col-D. They used pepsin, an enzyme secreted by stomach cells of vertebrates, to pinpoint the collagens. Unlike most proteins, Waite says, Col-P and Col-D don't break apart in response to pepsin. Since pepsin works best in an acidic environment, researchers simply placed byssal threads and pepsin in a weak solution of acetic acid. "Col-P and Col-D were the only proteins detectable after pepsinization," Waite explains. "Within byssal threads, these two collagens are distributed in a complementary gradient, with Col-P predominant in the elastic, proximal region, near the foot of the mussel, and more Col-D at the far, or distal end."

The UD team also examined the protein precursors for Col-P and Col-D, found in the mussel foot, where byssal threads are produced. Specific antibodies--proteins designed to detect and fight off foreign molecules by binding with them--helped Coyne target preCol-P. First, messenger RNA (ribonucleic acid) containing the genetic code for the protein was extracted from mussel foot tissue. Next, RNA was converted to the more stable DNA (deoxyribonucleic acid) form and cloned into bacteria, which expressed the protein encoded by the mussel's RNA. Designer antibodies, produced by a laboratory animal injected with Col-P, quickly latched onto the protein precursor expressed by bacterial clones.

Three Major Domains

The preCol-P in byssal threads contains three major domains, Coyne says. The middle section
'"/>

Contact: Ginger Pinholster
ginger.pinholster@mvs.udel.edu
302-831-6408
University of Delaware
18-Sep-1997


Page: 1 2 3 4

Related biology news :

1. Wonderfest science festival returns to Stanford Nov. 2-3
2. New "Wonder Peanut" Beats Olive Oil In Healthful Benefits
3. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
4. Scientists sequence genome of kind of organism central to biospheres carbon cycle
5. Scientists find nanowires capable of detecting individual viruses
6. Scientists discover potential new way to control drug-resistant bacteria
7. Scientists explore genome of methane-breathing microbe
8. Scientists decipher genetic code of biothreat pathogen
9. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
10. Scientists discover proteins involved in spread of HIV-1 infection
11. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance

Post Your Comments:
(Date:7/29/2014)... new study from UC San Francisco is the first ... accumulate overtime and accelerate cellular aging, these negative effects ... and sleeping well. , "The study participants who ... shortening than the ones who didn,t maintain healthy lifestyles, ... lead author Eli Puterman, PhD, assistant professor in the ...
(Date:7/28/2014)... the South Pole in 1911, but new research shows ... , Using data from 16 ice cores collected from ... South Pole, a group led by Joe McConnell of ... the most accurate and precise reconstruction to date of ... described in an article published today in the online ...
(Date:7/28/2014)... TEMPE, Ariz. - Reactions among minerals and organic compounds ... deep carbon cycle, they provide energy for the deep ... life. However, very little is known about how minerals ... Arizona State University have demonstrated how a common mineral ... negating the need for toxic solvents or expensive ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3
(Date:7/29/2014)... 2014 According to the new ... Analytics (Image Analysis Software), Delivery Modes (Web Based/Cloud Based) ... Trends to 2018", published by MarketsandMarkets, analyzes and studies ... as North America , ... the Rest of the World (RoW). Browse ...
(Date:7/29/2014)... A new report by Allied ... and geography) - Size, Share, Global Trends, Company Profiles, ... 2013 - 2020", suggests that the global surgical equipment ... registering a CAGR of 11.1% from 2014 to 2020. ... electro surgical devices in operative procedures by providing highly ...
(Date:7/29/2014)... TransVac Solutions, the trusted leader in automated waste, ... hospitals, will be exhibiting at booth #209 at the ... Technical Exhibition Aug. 3-6 in Chicago, Ill. ... cleaner, reducing infection risk and saving millions in labor ... Staff will be available at booth #209 to explain ...
(Date:7/29/2014)... Genera Energy Inc. , a ... supply chain advancements, has announced the deployment of ... and Supply ASSURE™. Both systems were developed ... at consolidating and simplifying the entire process, managing ... feedstock end users. , “Through the Energy Grange ...
Breaking Biology Technology:Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4
Cached News: