World's oldest mouse celebrates milestone birthday

ANN ARBOR, Mich. Yoda, the world's oldest mouse, celebrated his fourth birthday on Saturday, April 10, 2004. A dwarf mouse, Yoda lives in quiet seclusion with his cage mate, Princess Leia, in a pathogen-free rest home for geriatric mice belonging to Richard A. Miller, M.D., Ph.D., a professor of pathology in the Geriatrics Center of the University of Michigan Medical School.

Yoda was born on April 10, 2000 at the U-M Medical School. At 1,462-days-old, Yoda is now the equivalent of about 136 in human-years. The life span of the average laboratory mouse is slightly over two years.

"Yoda is only the second mouse I know to have made it to his fourth birthday without the rigors of a severe calorie-restricted diet," Miller says. "He's the oldest mouse we've seen in 14 years of research on aged mice at U-M. The previous record-holder in our colony died nine days short of his fourth birthday. 100-year-old people are much more common than four-year-old mice."

Miller is an expert on the genetics and cell biology of aging. To study the aging process, he has developed strains of mice, derived from wild mice captured in Idaho, that live longer, stay smaller and age more slowly than ordinary mice. Although extremely low-calorie diets have been shown by other scientists to produce very long-lived mice, the genetic approaches used in Miller's laboratory achieve longevity without the need to restrict food intake.

Miller's mouse colony also includes strains of mutant dwarf mice, developed at Jackson Laboratories, which are very small and long-lived. Yoda is the longest-living member of this unusual tribe.

Miller's geriatric mice are providing important clues about how genes and hormones affect the rate of human aging and risks of disease late in life. His current work focuses on identifying defects in T cells from aged mice that interfere with a normal immune response, and finding ways to reverse those defects.


Contact: Sally Pobojewski
University of Michigan Health System

Page: 1

Related biology news :

1. Worlds largest scientific society convenes regional meeting June 2-4 in Indianapolis
2. Worlds oldest modern hummingbirds described in Science
3. Worlds largest tiger reserve declared in Myanmar
4. Worlds first databank for all living systems
5. Worlds largest-ever sea turtle symposium to address plummeting populations of sea turtles
6. Worlds first robot scientist proves a major success in the lab
7. Worlds leading mad cow diagnostic company, responds to USDAs additional BSE protection measures
8. Worlds largest scientific society holds regional meeting in Columbia, Mo.
9. Worlds most alkaline life forms found near Chicago
10. Worlds largest forest birds may produce worlds deepest bird calls
11. Worlds largest scientific society holds regional meeting in Long Beach, Calif.

Post Your Comments:

(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
Breaking Biology Technology:
Cached News: