Worm neuron research may lead to powerful model for Parkinson's study

NASHVILLE, Tenn., It was a warm summer night that Tuesday a night not unlike many others he had spent working in the lab when Richard Nass, Ph.D. walked down the empty hallway and entered a small, darkened room. Settling himself onto a stool, he placed a shallow dish on the stage of the microscope before him and peered through the eyepieces. What he saw there or, rather, didnt see took him aback.

Nass saw the host of wriggling, transparent worms that he expected, but missing was the distinctive green glow that should have lit up the bodies of the worms like neon.

"I almost couldnt believe it," he said, shaking his head. The loss of green fluorescence that Nass observed in his worms told him that their dopamine neurons, which had been genetically altered to fluoresce green, had been destroyed by exposure to a chemical, 6-hydroxydopamine (6-OHDA). The results of the study, published this week in the journal Proceedings of the National Academy of Sciences, suggest that this tiny roundworm, named C.elegans, can serve as a powerful model for studying the molecular mechanisms underlying degeneration of dopamine neurons in the brains of patients with Parkinsons disease (PD).

The paper, co-authored by Nass, a post-doctoral research fellow in Pharmacology; Randy D. Blakely, Ph.D., Alan D. Bass Professor of Pharmacology; and David M. Miller, III, Ph.D., associate professor of Cell Biology, presents evidence for why and how the C. elegans model can be used to visually screen for genetic and environmental events that influence dopamine transporter expression and trigger dopamine neuron cell death.

Although rare genetic forms of PD have been identified, the molecular basis of dopamine neuron vulnerability and cell death in the majority of PD cases is poorly understood. Some theories on the cause involve exposure to environmental toxins, the generation of reactive oxygen species in brain cells, and inhibition of mitochondria, the sub

Contact: John Howser
Vanderbilt University Medical Center

Page: 1 2 3 4 5

Related biology news :

1. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
2. Gene mutation found for a form of juvenile-onset motor neuron disease
3. Introduction of the Rett protein in post-mitotic neurons rescues Rett Syndrome in mice
4. Bim notes in the neuronal executioners song
5. New study may explain how fats damage neurons in Alzheimers patients
6. Healthy neighbors rescue degenerating motor neurons
7. Creation of new neurons critical to antidepressant action in mice
8. Birth control for brain neurons
9. Link between neuronal calcium channel, mutated gene that causes Huntingtons disease identified
10. Kiss-and-run rules the inner lives of neurons
11. Ingenium publishes groundbreaking research on genetic basis for motor neuron degeneration

Post Your Comments:

(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the first in ... on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor ... live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition ...
(Date:7/1/2020)... VENICE, Calif. (PRWEB) , ... July 01, 2020 ... ... focused on building awareness and solutions for glioblastoma—the most common and aggressive adult ... and Lisa Haile, JD, PhD. Senior Fellows are charged with supporting the organization’s ...
(Date:6/23/2020)... MILTON KEYNES, England (PRWEB) , ... June 23, ... ... operations in Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and ... rapid response project to support testing operations in the fight against the COVID-19 ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... N.J (PRWEB) , ... July 29, 2020 , ... ... company, and Catalent, the leading global provider of advanced delivery technologies, development, and ... today announced that they have entered into a strategic partnership whereby Catalent will ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July ... ... provider of cloud-based software for the life sciences industry, today announced the ... presentation platform designed specifically for Medical Science Liaisons (MSLs) and other field ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this ... the only technology of its kind on the market and we were pleased that ... protective capacity of traditional cultured ingredients, creating a natural way to extend the shelf ...
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
Breaking Biology Technology:
Cached News: