HOME >> BIOLOGY >> NEWS
XsalF comes to the fore in brain regionalization

In vertebrates, the nervous system is divided into distinct regions patterned in a head-to-tail direction. Embryologists have long been interested in working out the means by which this regionalization is achieved, and for years the dominant theory has involved a two-step mechanism in which neural tissues are first induced lengthwise down the entire body axis, followed by a transformation step where a second signal specifies the posterior identities of the neural tissue, which can be induced by a number of factors including members of the Wnt and FGF gene families, and retinoic acid.

While there is much evidence to support this model, a number of recent studies have indicated that the specification of the forebrain (an anterior structure, presumed to be induced by the initial signal in the activation-transformation model) requires additional regulatory inputs as well. New work by scientists in the Laboratory for Organogenesis and Neurogenesis (Group Director, Yoshiki Sasai) at the RIKEN Center for Developmental Biology (CDB; Kobe, Japan) showing anterior neural specifying activity in the African clawed frog, Xenopus laevis, lends weight to the revisionist argument.

In an article published in the July 13 issue of Developmental Cell, Takayuki Onai et al. report that XsalF, the Xenopus homolog of spalt, a homeotic gene known to function in anterior-posterior segment identity in Drosophila, regulates the expression of forebrain and midbrain-specific genes. A series of experiments in which XsalF was misexpressed, deleted and its function blocked, showed direct linkage between XsalF expression and forebrain/midbrain identity.

XsalF was originally identified in a screen of the frog anterior neural plate, a structure that appears early in neural development. Sequencing of the gene, and analysis of the timing and spatial pattern of its expression showed that it codes a transcription factor related to Spalt and is expressed in the incipient for
'"/>

Contact: Doug Sipp
sipp@cdb.riken.jp
81-78-306-3043
RIKEN Center for Developmental Biology
12-Jul-2004


Page: 1 2 3

Related biology news :

1. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
2. Scientists characterize new breast tumor subtypes with poor clinical outcomes
3. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
4. Moving targets: when it comes to patterns, motion gets factored in
5. When reaper gene comes, cell death follows
6. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
7. Clock tells time at such speed that reading it becomes challenge
8. Little yellow molecule comes up big
9. When it comes to sperm competition, size can matterits the female who holds the aces
10. Hopkins scientists reveal how sound becomes electric
11. Researchers identify protein that overcomes leptin resistance

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
(Date:3/30/2017)... 30, 2017 Trends, opportunities and forecast in ... by technology (fingerprint, AFIS, iris recognition, facial recognition, hand ... by end use industry (government and law enforcement, commercial ... banking, and others), and by region ( North ... Asia Pacific , and the Rest of ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Los Angeles, CA (PRWEB) , ... ... ... Pharmaceuticals, Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) ... all uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed ...
(Date:10/10/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... October 10, ... ... risk management, technological innovation and business process optimization firm for the life sciences ... the BoxWorks conference in San Francisco. , The presentation, “Automating GxP ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree ... products targeting the needs of consumers who are incorporating medical marijuana into their ... Phoenix, Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture ... sector at their fourth annual Conference where founders, investors, innovative practitioners and collaborators ... ELEVATE pitch competition showcasing early stage digital health and med tech companies. , ...
Breaking Biology Technology:
Cached News: