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Xyzal shows significant improvements in quality of life for persistent allergic rhinitis sufferers

Paris, 9 June 2003 New data presented at the 22nd European Academy of Allergology and Clinical Immunology (EAACI), 7 - 11 June 2003, in Paris, France, today show that Xyzal® (levocetirizine) significantly improves patients' quality of life by 47.5% when compared to placebo, in patients with persistent allergic rhinitis (PER). Quality of life was assessed using a universally accepted, disease-specific method the Rhinitis Quality of Life Questionnaire (RQLQ). Significant improvements in quality of life were also seen with Xyzal® using a more generic scoring method, the SF-36 Physical Component Score (p<0.001).1

The XPERTTM study data also show that Xyzal® significantly improved symptoms of PER when compared to placebo over the first 4 weeks of the study (5.43 ± 0.15 vs. 6.56 ± 0.15). Symptom improvement which was seen on most individual symptoms as early as the first week was sustained over the 6 months of the study in patients treated with Xyzal® (p<0.001). Efficacy was assessed using Total Five Symptom Score (T5SS).1

These new Quality of Life and clinical data are from the XPERTTM (Xyzal in Persistent Rhinitis Trial) study, which looked at long-term treatment with Xyzal® of patients with PER. XPERTTM is the first large study investigating treatment of PER since it was newly-defined in the ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines.

Allergic rhinitis was previously subdivided into seasonal, perennial and occupational, based on time of exposure to allergens. ARIA believed this subdivision to be less than satisfactory, and hence advocated a new classification of allergic rhinitis in new guidelines. The new classification is based on duration and severity, and is subdivided into "intermittent" or "persistent" and into "mild" or "moderate-severe". A diagnosis of PER is made when symptoms last for more than 4 days a week
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Contact: Vicky Blonsky
vicky.blonsky@ketchum.com
44-207-611-3523
Ketchum
9-Jun-2003


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