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Xyzal shows significant improvements in quality of life for persistent allergic rhinitis sufferers

and for more than 4 weeks, suggesting chronic inflammation caused by persistent allergen exposure.

Commenting on the data, Professor G. Walter Canonica, one of the authors of the XPERTTM trial, and Director of Allergy and Respiratory Disease at Universit degli Studi di Genova, Italy, said: "For the first time, the XPERTTM study has given us a comprehensive investigation into PER a newly-defined disease subtype. The symptoms of PER are chronic and have a huge impact on a patient's quality of life. The XPERTTM study confirms that long-term treatment with Xyzal® is not only effective at treating the symptoms of persistent allergic rhinitis, but can also significantly improve a patient's quality of life. The study also suggests that continuous treatment for PER is required. This is of particular relevance to people who are suffering chronic symptoms at the height of the hayfever season, and to people whose symptoms will continue well into the autumn due to persistent house dust mite allergy."

The XPERTTM trial also showed that fewer patients treated with Xyzal® suffered from a co-morbid disease, such as asthma and upper respiratory tract infections, compared to patients treated with placebo (54% vs. 71% respectively). There were fewer incidences of asthma (7% vs. 13%) and upper respiratory tract infections (42% vs. 52%) in patients treated with Xyzal® than in patients who received placebo. This reduced co-morbidity resulted in the reduced use of medical resources over the duration of the study, and hence economic savings.1

Further pharmacoeconomic evaluation revealed that treatment of PER with Xyzal® led to fewer working days being lost as a result of uncontrolled symptoms, and to a reduction in loss of productivity at work. Loss of productivity at work and in performing usual daily activities due to allergic rhinitis or comorbidity was halved (-59
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Contact: Vicky Blonsky
vicky.blonsky@ketchum.com
44-207-611-3523
Ketchum
9-Jun-2003


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