HOME >> BIOLOGY >> NEWS
Yale and Alexion report advance in spinal cord repair

NAGOYA, JAPAN, Oct. 25, 1999 -- Researchers from the Yale University School of Medicine and Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) today reported that transplanting genetically modified pig cells into surgically damaged spinal cords of non-human primates can regenerate the myelin sheath around the injured fragment of the spinal cord. Alexion believes that these results represent a critical milestone in progressing its spinal cord product into patient trials.

The report, entitled "Xenotransplantation of Transgenic Pig Myelin Forming Cells Promotes Axonal Regeneration and Restores Conduction Across the Transected Spinal Cord," is based on research conducted in the laboratories of Dr. Jeffrey D. Kocsis of the Department of Neurology, Yale University School of Medicine, and Dr. William L. Fodor, Senior Director of Xenotransplantation at Alexion Pharmaceuticals, Inc. and their colleagues.

"This promising data demonstrates that immunoprotected transgenic pig cells can survive and regenerate myelin sheaths around damaged neurons within the spinal cords of non-human primates," said Stephen Squinto, Senior Vice President and Chief Technology Officer of Alexion. "Together with our findings also presented today which showed that these transgenic pig cells both engraft and restore electrical conductance in rodent models of spinal injury, these data suggest that this approach may lead to the development of a new therapy for spinal cord injury patients."

Specific antibody binding to the surface of a foreign cell initiates a process called the "complement" cascade, which results in the destruction of the foreign cell. Complement-mediated rejection of nerve cell xenografts presents a major obstacle to effectively replacing damaged cells in the central nervous system. Alexion scientists address this problem in two ways. First, they produce pig cells that reduce or eliminate the expression of certain pig sugars which are targeted by the triggering antibod
'"/>

Contact: Tom Baker
t.baker@noonanrusso.com
212-696-4455 Ext 205
Noonan/Russo Communications
24-Oct-1999


Page: 1 2 3

Related biology news :

1. Alexion and Yale discover harmful complement activation in patients with acute coronary syndrome
2. Harvard and Alexion researchers report successful transplantation of immuneprotected neurons in primate model of Parkinsons disease
3. March of Dimes statement on newborn screening report
4. Researchers report new gene test for isolated cleft lip and palate
5. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
6. Unicellular organisms contribute more nitrogen to ocean that reported earlier
7. Researchers report new gene test for isolated cleft lip and palate
8. British scientists exclude maverick colleagues, says report
9. New public policy & aging report highlights facts and fiction about anti-aging medicine
10. APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
11. Researchers report major advance in gene therapy technique

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... SOMERSET, N.J. (PRWEB) , ... August 25, 2020 ... ... technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and ... the upcoming 16th Annual PEGS Boston Virtual Conference & Expo, taking place between ...
(Date:8/21/2020)... ... August 19, 2020 , ... The 19th Annual Bio-IT ... data science, informatics and IT leaders goes VIRTUAL and announces its updated event ... change, Bio-IT takes the leadership role of keeping our life science community connected ...
(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle school ... STEM Scholar Program, a unique professional development program that provides advanced STEM (science, ... school science teachers nationwide. , Created in partnership between the National Stem Cell ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra ... life sciences and food industries, is pleased to announce that Charles Galea has ... Business Development. , Charles is an accomplished and results-driven sales executive with over ...
(Date:7/10/2020)... (PRWEB) , ... July 09, 2020 , ... ... called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, ... PolyU research team led by Dr MA has been using the zebrafish model ...
(Date:7/7/2020)... BOSTON (PRWEB) , ... July 06, 2020 , ... ... Innovative Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of ... Since 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... that the launch of a new clinical diagnostics immuno-oncology service, TissueInsight ... microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, ...
Breaking Biology Technology:
Cached News: