HOME >> BIOLOGY >> NEWS
Yale researchers discover new potential asthma therapeutic targets related to parasites and insects

An unusual protein called acidic mammalian chitinase (AMCase), is markedly increased in mouse models of asthma, making it an important link in finding the pathways that lead to asthma, Yale researchers report in today's issue of Science.

Asthma is a disease produced by chronic inflammation of the airways. The AMCase protein was not previously thought to be involved in asthma. It was known to digest chitin, which is found in the outer wall of insects and parasites, and was not thought to be involved in inflammation.

"We found that if we block the AMCase protein with an antibody or if we use an inhibitor that prevents it from digesting chitin, we can decrease asthma-like inflammation," said senior author Jack A. Elias, M.D., the Waldemar Von Zedtwitz Professor of Medicine and Section Chief and Professor of Internal Medicine/Pulmonary and Critical Care. "Since chitin is not present in our mouse models, this protein must be acting on something other than chitin. We do not know what that is right now."

The team also found that the protein is present in the airways of human asthmatics but not in control lungs. "We are hopeful that blocking AMCase in human asthmatics will have a similar beneficial effect on the human disease," said Elias.

The inflammation seen in asthma is driven by specialized lymphocytes (white blood cells), called T helper type 2 cells. Other cell types promote different kinds of inflammation in which the AMCase protein is not made in high amounts. If this protein is blocked, it will only alter asthmatic type inflammation, but not the other types of inflammation, which are needed to fight many infections.

"We also found that interleukin-13, a protein that is well known to be important in asthmatic type inflammation is required for increased production of AMCase," said Elias. "Another protein associated with asthmatic type inflammation, interleukin-4, was not required."

"The way that blocking AMCase inh
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
11-Jun-2004


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... ... Harper was three years old when her owners took her to the veterinarian ... in the joints. She was referred to a veterinary specialist to perform “salvage ... Christopher Eich of Southern California Veterinary Specialty Hospital , examined Harper and recommended ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... Windows and mobile, announces the launch of version 13.1. The new version extends ... Management API, and supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s ...
(Date:5/26/2019)... (PRWEB) , ... May 24, 2019 , ... Zolgensma (Novartis, ... as AVXS-101, was approved for clinical use in the United States by the Food ... virally-delivered gene therapy approved to treat inherited genetic disorders in the United States and ...
Breaking Biology News(10 mins):
(Date:5/21/2019)... Ethiopia (PRWEB) , ... May 21, 2019 , ... ... Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated ... and malting industry in Africa. The event, which is supported through a partnership ...
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are ... food and beverage products rely on these ingredients to create stable quality food ... declarations. This paradigm shift triggers food formulators to seek out alternatives for starches, ...
(Date:5/14/2019)... ... 14, 2019 , ... Gateway Genomics , a leading developer of prenatal ... to 5,000 square feet. , “This past year has seen exponential growth for ... CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed directly to our customers ...
(Date:5/7/2019)... ... May 06, 2019 , ... "The new ... number of repositories being asked to store cellular products being used in ... contributors who are world leaders, who have shared their expertise in building and ...
Breaking Biology Technology:
Cached News: