HOME >> BIOLOGY >> NEWS
Yale researchers discover new potential asthma therapeutic targets related to parasites and insects

An unusual protein called acidic mammalian chitinase (AMCase), is markedly increased in mouse models of asthma, making it an important link in finding the pathways that lead to asthma, Yale researchers report in today's issue of Science.

Asthma is a disease produced by chronic inflammation of the airways. The AMCase protein was not previously thought to be involved in asthma. It was known to digest chitin, which is found in the outer wall of insects and parasites, and was not thought to be involved in inflammation.

"We found that if we block the AMCase protein with an antibody or if we use an inhibitor that prevents it from digesting chitin, we can decrease asthma-like inflammation," said senior author Jack A. Elias, M.D., the Waldemar Von Zedtwitz Professor of Medicine and Section Chief and Professor of Internal Medicine/Pulmonary and Critical Care. "Since chitin is not present in our mouse models, this protein must be acting on something other than chitin. We do not know what that is right now."

The team also found that the protein is present in the airways of human asthmatics but not in control lungs. "We are hopeful that blocking AMCase in human asthmatics will have a similar beneficial effect on the human disease," said Elias.

The inflammation seen in asthma is driven by specialized lymphocytes (white blood cells), called T helper type 2 cells. Other cell types promote different kinds of inflammation in which the AMCase protein is not made in high amounts. If this protein is blocked, it will only alter asthmatic type inflammation, but not the other types of inflammation, which are needed to fight many infections.

"We also found that interleukin-13, a protein that is well known to be important in asthmatic type inflammation is required for increased production of AMCase," said Elias. "Another protein associated with asthmatic type inflammation, interleukin-4, was not required."

"The way that blocking AMCase inh
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
11-Jun-2004


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/25/2018)... , ... December 24, 2018 , ... ... The Rockefeller University have discovered a new use for a long-standing computational concept ... spam control, blocking unwanted files and messages. Using blacklisting as a filter to ...
(Date:12/20/2018)... TRIANGLE PARK, N.C. (PRWEB) , ... December 20, ... ... have been enhanced through upgraded processes and the completion of a new usability/observation ... Evaluations with the goal of ensuring medical devices and drug delivery devices/combination products ...
(Date:12/19/2018)... ... ... InTouchMD’s flagship product, Pulse , has been honored by PM360 as ... featuring the recognition in its 7th annual Innovations issue, created for purpose of recognizing ... device industries. , “This recognition comes at an exciting time for Pulse as we’re ...
Breaking Biology News(10 mins):
(Date:1/4/2019)... PARK, N.C. (PRWEB) , ... January 04, 2019 ... ... organization, is pleased to welcome Ted Hoffman to the firm. Ted will be ... years of experience working in and providing consulting services to the pharmaceutical industry. ...
(Date:12/19/2018)... (PRWEB) , ... December 19, 2018 , ... ... procedures at its first rate Stem Cell Training Course in Las Vegas. Training ... women. As regenerative procedures explode in popularity nationwide for aesthetics, having the training ...
(Date:12/14/2018)... , ... December 14, 2018 , ... ... Canada Inc., have been given the green light to immediately begin a clinical ... (AMD). , The medical devices bureau of Health Canada has granted what is ...
(Date:12/10/2018)... ... December 10, 2018 , ... ... and Manufacturing Organization (CDMO) with sites in China and the United States, ... aseptic fill finish solutions for monoclonal antibody (mAb) and antibody-drug conjugate (ADC) ...
Breaking Biology Technology:
Cached News: