HOME >> BIOLOGY >> NEWS
Yale researchers solve structure of the ribosome: groundbreaking achievement 'like climbing Mount Everest'

In a landmark achievement, Yale researchers have determined the atomic structure of the ribosome's large subunit, paving the way for more effective drugs to fight infection.

The findings, published in two separate articles in this week's issue of the journal Science, were derived in Yale laboratories led by Thomas Steitz, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry and investigator at the Howard Hughes Medical Institute, and Peter Moore, the Eugene Higgins Professor of Chemistry.

"This is like climbing Mt. Everest or running the four minute mile," Steitz said. "We have solved the structure of the ribosome's large subunit, which is the largest unique structure determined. We have established that the ribosome is a ribozyme, an enzyme in which catalysis is done by RNA, not protein."

The ribosome is the cellular structure responsible for synthesizing protein molecules in all organisms. In addition to enhancing the understanding of protein synthesis, the research offers new clues about evolution and has significant medical implications because the ribosome is a major target for antibiotics.

Many antibiotics cure disease by selectively inhibiting the protein synthesizing activity of large ribosomal subunits in disease-causing bacteria, while leaving human ribosomes alone. Unfortunately, over the years, many bacteria have become resistant

to these agents, and the possibility exists that the devastating bacterial diseases that were brought under control by antibiotics in the 1940s and 1950s will once again become scourges.

"Now that we know the structure of the large ribosomal subunit," Steitz said, "we can determine its exact structure with antibiotics bound to it." The same methods of "structure-based drug design" that led to the development of HIV protease inhibitors for AIDS can now be used on the ribosome, which is 100 times larger.

"The information that emerges should enable pharmaceutical co
'"/>

Contact: Karen Peart
karen.peart@yale.edu
203-432-1326
Yale University
9-Aug-2000


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/27/2019)... ... October 26, 2019 , ... Since 2010, The HOTH has served over ... the success of their clients, they’ve earned a place on the highly-competitive and desirable ... won many additional awards and accolades along the way. , Now, The HOTH ...
(Date:10/26/2019)... ... October 24, 2019 , ... World Cord Blood Day (WCBD) takes place ... midwives to learn about the current and future uses of cord blood stem cells, ... being used to treat and cure over 80 different life-threatening diseases, including leukemia, lymphoma, ...
(Date:10/26/2019)... ... October 25, 2019 , ... ... therapy in La Plata, MD. Orofacial myofunctional disorders (OMDs) are abnormal movement patterns ... and speaks. This can include anything from difficulty swallowing and limited tongue movement ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia Corporation, the global ... today announces that the U.S. Food and Drug Administration (FDA) has granted the ... temporary relief of chronic neck and shoulder pain of musculoskeletal origin. , Erchonia ...
(Date:10/3/2019)... ... October 01, 2019 , ... ... and reset itself, announced the midway point of its randomized research trial for ... study is to measure the efficacy of a non-invasive technology which compares tones ...
(Date:10/3/2019)... ... 02, 2019 , ... Today marked the official launch of ... program outsourcing success by cultivating radical improvements in leadership, staff, and broader project ... Reese, phaseUP™ brings clients deep, broad and unique expertise in the intricacies of ...
(Date:10/3/2019)... ... October 02, 2019 , ... eKare’s inSight® digital 3D imaging and wound ... by the East Midlands Academic Health Science Network (EMAHSN), the innovation arm of the ... by providing support to develop and deploy solutions to the most pressing challenges facing ...
Breaking Biology Technology:
Cached News: