HOME >> BIOLOGY >> NEWS
Yeast Provides Evidence For Continuous Membrane Theory

Researchers at the University of Chicago have new evidence to support a controversial theory about tiny intracellular structures called organelles. Their findings support the theory that certain organelles form an interconnected system where one organelle gives rise to another through outgrowths of its own membrane.

Their discoveries will also shed light on disorders such as Menkes disease and polycystic kidney disease, which are caused by defects in Golgi function.

The researchers studied a particular region of the cell where an organelle called the endoplasmic reticulum (ER) seems to give rise to another organelle called the Golgi apparatus. This process occurs at specific places along the ER called transitional ER (tER) sites.

"Our work strongly suggests that the Golgi apparatus grows directly out of the tER," says Benjamin Glick, assistant professor at the University of Chicago and lead author of the paper in the April 5 issue of the Journal of Cell Biology.

The Golgi apparatus, which consists of a stack of pancake-shaped membranes called cisternae, is responsible for modifying and packaging proteins for export to the cell surface. According to the membrane outgrowth theory, Golgi cisternae are transient structures, with new cisternae constantly being generated at tER sites.

Glick realized he had a unique opportunity to test this hypothesis when he noticed very different-looking Golgi formations in two yeast species: Pichia pastoris, which has the typical coherent stacked Golgi cisternae, and Saccharomyces cerevisiae, or brewer's yeast, which has dispersed individual cisternae scattered throughout the cell.

"We used these two yeasts because they are closely related, yet they have completely different Golgi structures. Saccharomyces is definitely an oddity because almost every other kind of cell has well-organized Golgi stacks. We reasoned that the dispersed Golgi in Saccharomy
'"/>

Contact: Sharon Parmet
sparmet@mcis.bsd.uchicago.edu
773-702-6241
University of Chicago Medical Center
2-Apr-1999


Page: 1 2

Related biology news :

1. Yeast mutations offer window into human disease
2. Yeast model yields insights into Parkinsons disease
3. Yeast helps researchers better understand Parkinsons mystery
4. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
5. Yeast genomes reveal new sites of gene control
6. Yeast research targets drug resistance battle
7. Yeast underscores complexity of genetic variation between people
8. Yeast Rises To A New Occasion
9. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs
10. Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility
11. Mutate Or Die: New Polymerase Gives Desperate Yeast An Option

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2020)... ... March 11, 2020 , ... USARAD Holdings ... Siemens Healthineers and several healthcare VC firms introduces a first of its kind ... 100 countries and has caused over 4,000 fatalities to date. Over the years, ...
(Date:3/9/2020)... ... March 09, 2020 , ... ... growth rate of 64% last year, as enterprises sought to achieve competitive ... Group. Unfortunately, only 13% of all transformation efforts delivered the intended consequences. ...
(Date:3/5/2020)... , ... March 05, 2020 , ... Patients in need ... dental implants from Dr. Nickelice Brand of Dental Implants of Ocala. Same-day dental ... get an entirely new smile in just one day. This treatment utilizes advanced technology ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... ... Join Forrest Brown, Engineering Services Manager – Northeast Region and Jarred Christofaro, Engineering ... session on Wednesday, February 26, 2020 at 1pm EST to learn about:, ... add manufacturing flexibility in the future, especially for CMOs , C&Q Strategy ...
(Date:2/19/2020)... ... February 18, 2020 , ... ... the launch of a new and unified global brand identity, as it celebrates ... complex engineering challenges, as well as an enthusiasm for designing and manufacturing state-of-the-art ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... from a long-term follow-up clinical study of outpatient L4-L5 lumbar interspinous fixation ... Unlike extension block design, the Inspan device fixates the spine to allow ...
(Date:2/5/2020)... FARMINGTON, Conn. (PRWEB) , ... February 04, 2020 ... ... that develops tools for characterizing microbiome populations down to the strain level, has ... Limited, will sell Shoreline Biome’s microbiome kits and other products to companies and ...
Breaking Biology Technology:
Cached News: