HOME >> BIOLOGY >> NEWS
Yeast genomes reveal new sites of gene control

St. Louis, May 29, 2003 Researchers at Washington University School of Medicine in St. Louis have begun unraveling the network of genes and proteins that regulate the lives of cells. The investigators compared the genome of the yeast Saccharomyces cerevisiae (S. cerevisiae) to those of five other yeast species to identify all the locations at which molecules known as regulatory proteins attach to DNA to turn genes on and off. The study is published in the May 30 issue of the journal Science.

Among the many potential sites of gene regulation, 79 were predicted to be definitive new regulatory sites. The investigators also discovered 43 new genes and determined that 515 suspected genes are not genes at all. The findings revised the estimated number of genes in the S. cerevisiae genome from 6,331 to 5,773.

"This is the first step in understanding the gene-regulation network in a simple cell," says principal investigator Mark Johnston, Ph.D., professor of genetics and interim chair of genetics. "This work also will provide guidelines for analyzing the regulatory network of human cells, which will be a much more complex task."

Regulatory sequences are important, Johnston notes, because they are the basis of development. For example, a liver cell differs from a brain cell not because they have different genesboth cells have the same set of genesbut because of the genes they use. And thats determined by the regulatory sequences that activate one set of genes in the liver and another set in the brain. A variety of diseases, including cancer, are caused by problems in gene regulation.

Identifying gene regulatory sites is not easy, however. These regions serve as docking sites for DNA binding proteins that turn the gene on or off. They lack the typical DNA patterns that help scientists recognize the body of the gene, which contains information about the structure of a protein.

Johnston and his colleagues compared the genomes of S. cere
'"/>

Contact: Darrell E. Ward
wardd@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
29-May-2003


Page: 1 2

Related biology news :

1. Yeast mutations offer window into human disease
2. Yeast model yields insights into Parkinsons disease
3. Yeast helps researchers better understand Parkinsons mystery
4. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
5. Yeast research targets drug resistance battle
6. Yeast underscores complexity of genetic variation between people
7. Yeast Provides Evidence For Continuous Membrane Theory
8. Yeast Rises To A New Occasion
9. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs
10. Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility
11. Mutate Or Die: New Polymerase Gives Desperate Yeast An Option

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2020)... ... March 02, 2020 , ... Philadelphia IP law firm Panitch ... J.D. has joined the firm as a Partner, and Stephany G. Small, Ph.D., has ... patent attorney and will be a partner in the firm’s biotechnology and life science ...
(Date:2/28/2020)... OMAHA, Neb. (PRWEB) , ... February 28, 2020 , ... ... win the 2020 Vaccine Industry Excellence (ViE) award for Best Clinical Trial ... is a finalist for the Best Clinical Trial Network award. These nominations were the ...
(Date:2/28/2020)... ... February 27, 2020 , ... Regen Suppliers is now ... rate PDO thread lift products are not only one of the only ... invasive thread lift procedures are increasing exponentially in popularity, as they represent an excellent ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... ... March 10, 2020 , ... Lifecycle Biotechnologies announced today that ... Texas to be used as a biopharmaceutical and biotechnology production and development campus. Lifecycle ... as well as its production and development hub. The company expects to relocate from ...
(Date:3/2/2020)... ... ... McBee, Moore and Vanik IP, LLC (MMV IP) has been ranked 12th in ... According to statistics compiled by Harrity Anaytics, MMV IP was listed as the U.S. ... 2019. Technology center 1600 at the US Patent Office (“USPTO”) specializes in the examination ...
(Date:2/21/2020)... , ... February 20, 2020 , ... ... supply chain transparency and reassuring consumers that what’s listed on an ingredient panel ... ingredients, Nutrition21 has introduced this solution with the adoption of CertainT, which is ...
(Date:2/19/2020)... ... February 19, 2020 , ... Red Nucleus, ... sciences industry, today announced the opening of a new office in Tokyo, Japan. ... R&D. , Red Nucleus announced the new office in response to customer requests ...
Breaking Biology Technology:
Cached News: