Yeast genomes reveal new sites of ge...( visiae to five other yeast species hyp...)

Yeast genomes reveal new sites of gene control

visiae to five other yeast species, hypothesizing that the regions that were most alike in all six would be potential regulatory sites.

The investigators found about 8,000 of these conserved sites, about one-third of which already were known regulatory sequences. After eliminating the known sites from the total, the investigators searched for other evidence that these sites are functional, and pinpointed 79 sites located within or near genes which are excellent candidates for new regulatory sequences.

The team will is now refining the number of sites by determining which yeast regulatory proteins bind to the them.

"Now," Johnston says, "we can begin tackling the really interesting question: how a relatively small number of regulatory proteins coordinate the activity of more than 5,700 genes to maintain a healthy, growing yeast cell."

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Contact: Darrell E. Ward
wardd@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
29-May-2003

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