HOME >> BIOLOGY >> NEWS
Yeast mutations offer window into human disease

This release is also available in French.

Different combinations of genetic mutations may give rise to diverse human traits, including complex diseases such as schizophrenia, say scientists at the University of Toronto and McGill University in Montreal.

Drs. Brenda Andrews and Charles Boone of U of T and Howard Bussey of McGill used simple yeast cells to demonstrate that there are many different combinations of genetic mutations that can lead to cell death or reduced cell fitness. The research team will now focus on mapping gene interactions for those yeast genes that are similar to human genes. Their study appears in the Feb. 6 issue of the journal Science.

The researchers crossed a yeast strain carrying a mutation in a particular gene of interest with a collection or "array" of other yeast strains to determine which gene pairs were lethal. The team studied more than 4,000 of these interactions involving gene pairs and was able to provide a large scale "genetic interaction network" that provokes new ideas about how genes interact to produce different traits.

For example, the researchers determined that genes arrange themselves in "neighbourhoods" or small networks. A gene is more likely to interact with its "neighbour," they discovered, than with more distant genes. Each yeast gene has on average about 30 of these interactions over the life of a cell, many more than had been predicted by previous experiments. By understanding the composition of these genetic "neighbourhoods," it is possible to predict which genes will interact and which traits will result when two genes combine.

"Constructing these networks will help human geneticists to focus their research on the culprits of disease," says Andrews, chair of U of T's medical genetics and microbiology department. "If we can begin to construct these kinds of networks in an intelligent way, we mi
'"/>

Contact: Elaine Smith
elaine.smith@utoronto.ca
416-978-5949
University of Toronto
5-Feb-2004


Page: 1 2

Related biology news :

1. Yeast model yields insights into Parkinsons disease
2. Yeast helps researchers better understand Parkinsons mystery
3. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
4. Yeast genomes reveal new sites of gene control
5. Yeast research targets drug resistance battle
6. Yeast underscores complexity of genetic variation between people
7. Yeast Provides Evidence For Continuous Membrane Theory
8. Yeast Rises To A New Occasion
9. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs
10. Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility
11. Mutate Or Die: New Polymerase Gives Desperate Yeast An Option

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
Breaking Biology Technology:
Cached News: