Yeast underscores complexity of genetic variation between people

Researchers at Fred Hutchinson Cancer Research Center have harnessed the power of yeast - a simple, single-celled organism crucial for brewing beer and baking bread - as a model to study trait inheritance and the genetics of complex conditions and characteristics at the most basic, molecular level.

Fred Hutchinson geneticist Leonid Kruglyak, Ph.D., and colleagues will report their findings in the April 26 edition of Science. Rachel Brem, Ph.D., and Gael Yvert, Ph.D., both fellows in Kruglyak's laboratory, share first authorship of the paper.

Complex traits, which range from diseases like diabetes and cancer to behaviors like violence and aggression, have been notoriously difficult to study in humans and other mammals, the systems in which most such analyses have been conducted.

While yeast provides a powerful new avenue for studying natural variation that results from complex genetic interactions, the researchers caution that even in the case of this simple fungus, the study of complex traits is likely to remain a formidable challenge in biology.

"The good news is that our method worked and that we can use it as a way to study complex traits, Yvert said. "We can expand it to the study of other organisms. The caution is that we're still dealing with a very complex system that is likely to be even more so in humans."

"Complex" diseases of civilization typically arise from a variety of inherited and acquired mutations in more than one gene. Identifying the many genetic factors underlying conditions such as cancer and heart disease poses a much bigger challenge to geneticists than rare disorders such as Huntington's disease and cystic fibrosis, which are always traceable to a single genetic defect.

To date there have been no complex diseases or inherited traits in humans for which all of the causal genetic factors have been identified. Finding multiple genetic regions implicated in any one disease or trait has been difficult because the

Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Page: 1 2 3

Related biology news :

1. Yeast mutations offer window into human disease
2. Yeast model yields insights into Parkinsons disease
3. Yeast helps researchers better understand Parkinsons mystery
4. Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug
5. Yeast genomes reveal new sites of gene control
6. Yeast research targets drug resistance battle
7. Yeast Provides Evidence For Continuous Membrane Theory
8. Yeast Rises To A New Occasion
9. Bakers Yeast Causes Chemical Reactions And Sweet Smelling Labs
10. Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility
11. Mutate Or Die: New Polymerase Gives Desperate Yeast An Option

Post Your Comments:

(Date:8/14/2019)... ... August 14, 2019 , ... Gateway Genomics , a leading developer of ... the 38th annual Inc. 500|5000 list of fastest growing private companies, in ... have been founded and generating revenue by March 31, 2015. Ranking in the list ...
(Date:8/6/2019)... (PRWEB) , ... August 06, 2019 , ... ... identifies a computational modeling system that could have far-reaching implications for personalized medicine, ... least squares regression (PLSR), is able to predict which stem cell donors and ...
(Date:8/6/2019)... ... August 06, 2019 , ... The demand for plant-based ... in particular quickly entered the limelight – meat alternatives. Yet, to make these ... emulsifying ingredient such as methyl cellulose. This ingredient is highly synthetic. Having a ...
Breaking Biology News(10 mins):
(Date:7/19/2019)... (PRWEB) , ... July 18, 2019 , ... ... known as “Ravi Everest,” will be joining forces with California-based charity Coalition Duchenne ... from July 20-22nd. Coalition Duchenne raises awareness and funding for Duchenne muscular dystrophy ...
(Date:7/17/2019)... ... July 16, 2019 , ... ... the development and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), an AveXis gene therapy ... Novartis company, will have dedicated manufacturing space at the new, state-of-the-art commercial ...
(Date:7/11/2019)... ... ... At the most recent stem cell training course in Las Vegas ... Heroes Program. The Veterans included individuals and families from all over the US, with ... military Veteran, teacher or first responder to receive a regenerative therapy at a training ...
(Date:7/9/2019)... , ... July 08, 2019 , ... ... The company’s SmartLight Indicator was recognized as the 2019 Innovative Product of the ... forward. The prestigious awards were during Sensors Expo & Conference 2019, ...
Breaking Biology Technology:
Cached News: