You are what you eat: New insight into autophagy

Somewhere between cannibalism and recycling, the process known as autophagy plays a key role in regulating cell growth, metabolism and survival. Autophagy, literally gaining nutrition by consumption of one's own tissues, is a normal response to starvation in which portions of a cell are sequestered and digested so that the breakdown products can be used as a nutrient source. Now, adding to information about autophagy in single-celled organisms, two research papers published in the August issue of Developmental Cell shed new light on the molecular mechanisms of autophagy in the fruit fly, Drosophila.

The control of autophagy is regulated through multiple signaling pathways by nutritional, hormonal and developmental cues. The well-known regulators of nutrient signaling and cell growth, phosphoinositide 3-kinase (PI3K) and a downstream molecule called TOR, have been implicated in suppression of autophagy in mammalian cells. However, the mechanisms that link these effectors to autophagy in multicellular animals are poorly understood.

Researchers led by Dr. Harald Stenmark from The Norwegian Radium Hospital in Oslo examined autophagy in the Drosophila fat body using a microscope-based visualization technique. The Drosophila fat body stores nutrients in much the same way that the liver and fat tissue do in mammals. Starvation and inhibition of PI3K or TOR induced autophagy in the Drosophila fat body. "While the molecular machinery of autophagy is largely conserved from yeast to mammals, the control of autophagy in multicellular animals is necessarily more complex than in yeast, as it is likely to be involved in functions other than the starvation response," writes Dr. Stenmark. Stenmark's group went on to show that that ecdysone, an insect hormone regulating development, has the ability to promote programmed autophagy via downregulation of PI3K signaling.

A second study led by Dr. Thomas P. Neufeld from th

Contact: Heidi Hardman
Cell Press

Page: 1 2

Related biology news :

1. Brown research reveals key insight into memory-making
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Heart gene yields insights into evolution, disease risk
5. A genetic disorder yields insight into genes and cognition
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Two-month study of life in mid-Atlantic yields trove of species, new insights & questions
8. New survey reveals insights into unique relationship between mothers and pediatricians
9. Study yields insights into precancerous condition
10. Comparing primate genomes offers insight into human evolution
11. UW study: Migrating birds offer insight into sleep

Post Your Comments:

(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... SARASOTA, FL (PRWEB) , ... ... ... Inc. (RPS®) today announces publication of a United States multicenter, prospective clinical ... single use, disposable, point-of-care diagnostic test capable of identifying clinically significant acute ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... (PRWEB) , ... October 10, ... ... development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed ... targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with ...
Breaking Biology Technology:
Cached News: