HOME >> BIOLOGY >> NEWS
Zebrafish may point the way to mending a broken heart

Howard Hughes Medical Institute researchers have found that the secret to mending a broken heart at least at the molecular level resides within the two-chambered heart of a fish commonly found in household aquariums. The scientists showed that the zebrafish can regenerate its heart after injury, and their studies suggest that understanding cardiac regeneration in this fish may lead to specific strategies to repair damaged human hearts.

Many studies have documented that various invertebrates can regenerate vital organs. But most vertebrates and all mammals develop scarring in response to cardiac injury, with minimal regeneration of heart muscle. In an article published in the December 13, 2002, issue of the journal Science, Howard Hughes Medical Institute investigator Mark T. Keating and colleagues at Harvard Medical School and Children's Hospital in Boston report that the zebrafish is one vertebrate that is capable of cardiac regeneration. Two months after Keating and his colleagues removed 20 percent of the heart in zebrafish, the fish had fully regenerated the excised portion of the heart. Keating's group also reported that zebrafish with an induced mutation in a specific gene failed to regenerate heart tissue and instead developed scarring.

Improved understanding of heart regeneration and the associated problem of cardiac scarring have lagged behind "for want of a genetically manipulable system to study the problem," Keating said. Very few genetically well-characterized organisms regenerate damaged heart muscle, and most scientists who study regeneration focus on fully regenerating invertebrates including planarians, or flatworms, and the Hydra polyps, he said. In addition, the complex and poorly understood genomes of these organisms have proven difficult for scientists to manipulate in experiments.

Researchers have studied organ regeneration in vertebrates
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
12-Dec-2002


Page: 1 2 3 4

Related biology news :

1. Zebrafish model human development and disease
2. Zebrafish genetic research results in significant discovery for geobiologists
3. Zebrafish studies provide insight into blood-cell formation
4. Zebrafish could become genetics lab rat of choice
5. Zebrafishs powerful heart gene could lead to transplant therapy
6. Mechanism Discovered For Determining Early Vertebrate Body Plan: New Zebrafish Mutants Afford Deeper Look Into Embryonic Patterning
7. Hunt for a new plant hormone points to carotenoids
8. DNA tests point to extinction of 2 distinctive arctic bird populations
9. Scientists pinpoint molecules that generate synapses
10. University of Chicago scientists pinpoint cellular cause of SIDS
11. Gene alteration points to longevity, thinness

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/5/2019)... TORONTO (PRWEB) , ... January 04, 2019 , ... ... Chief Architect – two experts in Healthcare & Life Sciences from MarkLogic – ... EST (4pm GMT). , This presentation outlines the challenges of using real world ...
(Date:1/4/2019)... ... January 03, 2019 , ... Over the last few years, ... discovery research workflows with biology ranging from single cell-type spheroids to highly complex ... studies, they create several challenges that need to be overcome in order to ...
(Date:12/27/2018)... ... December 27, 2018 , ... AxioMed completed its ... Boston facility, and is now raising growth capital to ramp up demand for ... against inferior ball and socket discs. The capital raise is targeted to qualified ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... Leading authority ... an all-new, how-to guide with his “The Referral Playbook: How to Increase Sales ... of the book proceeds will go to the Alzheimer’s Foundation of America (AFA). ...
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic software ... – has been used to convict a Wyoming man of third-degree sexual assault, a ... used STRmix™ to test for DNA on the couch cushions on which the sexual ...
(Date:11/29/2018)... ... November 29, 2018 , ... RAGS, today announced the closing ... Seed Fund, with participation from existing investor and board member Jeremy Andrus, CEO of ... Cotopaxi. The additional funding will enable the company to accelerate its growth and expand ...
(Date:11/27/2018)... , ... November 27, 2018 , ... New patients in ... Dr. Dan Myers’ practice for treatment, with or without a referral. Dr. Myers has ... tools, including porcelain veneers, dental implants, bridges and custom crowns. , As a ...
Breaking Biology Technology:
Cached News: