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ZymoGenetics researchers identify novel Interleukin that plays key role in immune system regulation

inical studies."

ZymoGenetics recently announced its establishment as an independent private company in conjunction with the signing of a $150 million private placement. The proceeds from this financing will be used to further accelerate ZymoGenetics targeted bioinformatics-driven programs for the discovery and development of novel therapeutic proteins.

Study Findings

ZymoGenetics researchers describe for the first time the identification of IL-21 ligand, and the interaction of IL-21 and its receptor, IL-21R, two proteins that are members of the family of molecules known as Class I cytokines and Class I cytokine receptors. Similar to other Class I cytokines such as erythropoietin (Epogen) and G-CSF (Neupogen), two potent stimulators of cell proliferation, initial biological studies indicate that IL-21 promotes rapid activation of immune system cells that are critical for defending the body against invading bacteria, viruses and cancer cells. Specifically, IL-21 has been shown to:

-Promote production of natural killer (NK) immune cells from bone marrow

-Improve the ability of mature NK cells to lyse (destroy)"non-self" target cells

-Stimulate expansion of select B and T cell populations.

"Critical to our ability to more fully understand the biological functions of IL-21 was our identification of the novel IL-21 protein itself as well as its corresponding receptor. We believe that these proteins work together to activate components of both the innate and acquired arms of the immune system," noted Frank Collins, Senior Vice President of Research at ZymoGenetics. "Because IL-21 promotes the proliferation and expansion of cells needed to defend against invaders, the molecules may have broad utility in therapeutic applications such as protecting against viral infection, enhancing vaccines, boosting the efficacy of chemotherapy or treating autoimmune disease. Our continued biological studies of IL-21 will clarify
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Contact: Sharon Karlsberg
skarlsberg@fkhealth.com
617-761-6767
Feinstein Kean Healthcare
1-Nov-2000


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