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$3.4 million directed to key UW-Madison MS study

MADISON -- In an effort to develop new techniques to repair and protect the nervous system in multiple sclerosis patients, including the use of human stem cells, the National Multiple Sclerosis Society has awarded $3.4 million to a team of University of Wisconsin-Madison scientists.

The group, led by School of Veterinary Medicine professor Ian D. Duncan, is developing cell transplant techniques that may one day be used to repair the damaged myelin -- the critical sheathing of nervous system fibers -- characteristic of the debilitating and unpredictable disease.

"It's all about myelin repair and protecting nerve fibers," says Duncan, an international authority on myelin and myelin-related diseases. "The goal is to translate bench research into clinical application."

Multiple sclerosis -- which affects an estimated 2.5 million people worldwide, 400,000 people in the United States and 10,000 in Wisconsin -- involves a misdirected attack by the immune system on myelin, the nerve fiber coating that speeds the signals of the central nervous system. Multiple sclerosis also destroys the underlying nerve fiber, causing symptoms such as numbness, blindness, cognitive dysfunction and paralysis.

An important part of the Wisconsin project, according to Duncan, will be efforts to direct human stem cells to become myelinating cells that could be used in transplants to repair the nervous system lesions characteristic of multiple sclerosis.

The project, Duncan adds, will also expand studies of the antibiotic minocycline, a drug that has shown potential for protecting nerve fibers and mitigating the debilitating symptoms of multiple sclerosis. Duncan's lab has already shown that the drug has anti-inflammatory properties in an animal model of MS.

The Wisconsin team, Duncan says, plans to deploy powerful, state-of-the-art imaging technologies, including magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), to image lesi
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Contact: Ian Duncan
duncani@svm.vetmed.wisc.edu
608-263-9828
University of Wisconsin-Madison
10-Aug-2005


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