HOME >> BIOLOGY >> NEWS
2-step process filters evolution of genes of human and chimpanzee

Although the human and chimpanzee genomes are distinguished by 35 million differences in individual DNA "letters," only about 50,000 of those differences alter the sequences of proteins. Of those 50,000 differences, an estimated 5,000 may have adaptive consequences in the evolutionary divergence between these two species, according to a study published in the March 6, 2007, issue of the Proceedings of the National Academy of Sciences.

Before such a new and beneficial mutation can take its place in the human genome it has to pass through a rigorous two-stepnegative and positivescreening process, say the study authors, evolutionary geneticists from the University of Chicago, the University of Tokyo and the University of Washington. Both steps focus on the most radical changes.

In step one, mutations, the genetic equivalent of typographical errors, are randomly introduced. When these mutations are still rare in the population, only strongly deleterious ones get weeded out through negative selection. The more radical mutations are more likely to be harmful and quickly removed. For those that are only slightly harmful, neutral or beneficial, the selective forces are weak and luck determines their fates.

In step two, a new mutation that has been fortunate enough to survive the initial elimination process, and confers some benefit, can then spread quickly through positive selection. The more radical the mutation, at this point, the faster it is likely to spread.

"We found that the same genetic changes that are unlikely to survive early negative selection are the ones that spread most quickly once they gain a foothold," said the studys senior author Chung-I Wu, Ph.D., professor of ecology and evolution at the University of Chicago. "To reach that conclusion, we needed to decouple the two steps of evolution and classify mutations into many different kinds."

The researchers used the very large survey of human ge
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
5-Mar-2007


Page: 1 2 3

Related biology news :

1. Hepatitis C helicase unwinds DNA in a spring-loaded, 3-step process
2. N.C. A&T food scientist develops process for allergen-free peanuts
3. The UAB heads a European research project on proteases and pathological processes
4. Herpes virus hijacks DNA repair process
5. Molecular motors may speed nutrient processing
6. Study shows response to financial loss parallels brains processing of pain
7. A rainbow of methods promises insights into biological processes and diseases
8. Cancer scientists create human leukemia process to map how disease begins, progresses
9. Information processing in the central nervous system: the signalling system controlling movement
10. UCLA identifies new molecule involved in the bodys processing of dietary fat
11. Newly discovered platform for processing dietary fat

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: step process filters evolution genes human and chimpanzee

(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
(Date:3/31/2015)... NEW YORK , March 31, 2015  Elephant ... the "Company"), a global provider of Software Defined Network ... solutions, today announced total revenue of approximately $20.4 million ... to a restated $19.5 million for the year ended ... of calendar 2014, the Company had completed its multi-year ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
(Date:4/24/2015)... April 24, 2015  Pfenex Inc. (NYSE MKT: PFNX) ... biosimilar therapeutics including high value and difficult to manufacture ... offering of 6,000,000 shares of its common stock at ... Of the shares being offered, 2,610,000 are being offered ... offered by existing stockholders. Pfenex will not receive any ...
(Date:4/24/2015)... 24 , 2015 PAREXEL International Corporation ... provider, today announced that Partnerships in Clinical Trials named ... the 2015 Clinical Innovator of the Year.  The honor ... for the Company,s Perceptive MyTrials ® Data-Driven Monitoring ... night during the 2015 Partnership Awards in ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Athena ... personal development of executive women in San Diego’s technology ... the 17th Annual Pinnacle Awards at their Gala on ... Hyatt Hotel. Register now at http://athenasd.org/events/ , ... support the Athena San Diego vision of fostering networking, ...
(Date:4/23/2015)... , April 23, 2015 BioTE Medical President ... book "Age Healthier Live Happier - Avoiding Over-Medication through ... Age Management Medicine Group Conference at JW Marriott / ... ",Age Healthier Live Happier, is a welcomed ... over-medication and searching for a higher quality of life ...
Breaking Biology Technology:Pfenex Inc. Announces Pricing Of Follow-on Offering 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3
Cached News: