HOME >> BIOLOGY >> NEWS
2-step process filters evolution of genes of human and chimpanzee

Although the human and chimpanzee genomes are distinguished by 35 million differences in individual DNA "letters," only about 50,000 of those differences alter the sequences of proteins. Of those 50,000 differences, an estimated 5,000 may have adaptive consequences in the evolutionary divergence between these two species, according to a study published in the March 6, 2007, issue of the Proceedings of the National Academy of Sciences.

Before such a new and beneficial mutation can take its place in the human genome it has to pass through a rigorous two-stepnegative and positivescreening process, say the study authors, evolutionary geneticists from the University of Chicago, the University of Tokyo and the University of Washington. Both steps focus on the most radical changes.

In step one, mutations, the genetic equivalent of typographical errors, are randomly introduced. When these mutations are still rare in the population, only strongly deleterious ones get weeded out through negative selection. The more radical mutations are more likely to be harmful and quickly removed. For those that are only slightly harmful, neutral or beneficial, the selective forces are weak and luck determines their fates.

In step two, a new mutation that has been fortunate enough to survive the initial elimination process, and confers some benefit, can then spread quickly through positive selection. The more radical the mutation, at this point, the faster it is likely to spread.

"We found that the same genetic changes that are unlikely to survive early negative selection are the ones that spread most quickly once they gain a foothold," said the studys senior author Chung-I Wu, Ph.D., professor of ecology and evolution at the University of Chicago. "To reach that conclusion, we needed to decouple the two steps of evolution and classify mutations into many different kinds."

The researchers used the very large survey of human ge
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
5-Mar-2007


Page: 1 2 3

Related biology news :

1. Hepatitis C helicase unwinds DNA in a spring-loaded, 3-step process
2. N.C. A&T food scientist develops process for allergen-free peanuts
3. The UAB heads a European research project on proteases and pathological processes
4. Herpes virus hijacks DNA repair process
5. Molecular motors may speed nutrient processing
6. Study shows response to financial loss parallels brains processing of pain
7. A rainbow of methods promises insights into biological processes and diseases
8. Cancer scientists create human leukemia process to map how disease begins, progresses
9. Information processing in the central nervous system: the signalling system controlling movement
10. UCLA identifies new molecule involved in the bodys processing of dietary fat
11. Newly discovered platform for processing dietary fat

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:7/24/2017)... Lawrence, MA (PRWEB) , ... July 24, 2017 , ... ... (TET-SL) has been accepted by the National Conference on Interstate Milk Shipments (NCIMS) Laboratory ... its Pilot Program, set to launch July 1, 2017. , The NCIMS voted at ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... today announced that the stock market news outlet had initiated coverage on ... testing that screens and identifies exposure, progression and risk analysis from specific ...
(Date:7/20/2017)... , ... July 20, 2017 , ... Dr. Asher Kimchi, ... winning recipients of the 2017 IAC Awards at the 22nd World Congress on Heart ... also named four faculty to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, ...
(Date:7/20/2017)... ... July 20, 2017 , ... Corista, a leader in ... intelligence Tuesday, July 25, during the Association of Pathology Chairs’ Jubilee Meeting in ... , Baras, Associate Director of Pathology Informatics, will present “The Digital Pathology Experience ...
Breaking Biology Technology:
Cached News: