HOME >> BIOLOGY >> NEWS
A Jekyll-and-Hyde enzyme's role in Alzheimer's

Researchers have discovered how a brain enzyme important in the development and maintenance of learning and memory also plays a key role in the death of neurons in neurodegenerative disorder such as Alzheimer's disease (AD). They found that the enzyme's transformation from Jekyll to Hyde may be due to abnormal activation of the brain's mechanism to compensate for the damage from such diseases. This compensatory mechanism may also function in normal aging, they said.

In their article in the December 8, 2005, issue of Neuron, Li-Huei Tsai and colleagues said their findings in mice could offer a model to study how normal neural mechanisms can go awry to contribute to the brain degeneration of AD.

The researchers' studies concentrated on a key brain regulatory enzyme called Cdk5. Elevated levels of Cdk5 had been found in the brains of AD patients, as well as elevated levels of a regulatory protein called p25 that is known to hyperactivate Cdk5. Researchers had found that the hyperactivating p25 is produced when the normal regulatory protein for Cdk5, called p35, is snipped into the shorter p25 by another enzyme.

In their experiments, the researchers used mice in which they could switch on p25 at will in the brain's learning and memory center, the hippocampus. In these mice, they found that switching on p25 for only two weeks actually enhanced learning and memory compared to normal mice. The two-week p25 mice could learn more quickly to associate a tone or environment with a mild electrical shock and to find a platform submerged in a pool of murky water.

In contrast, found the researchers, mice in which p25 had been switched on for six weeks showed impaired learning and memory in these tasks. Physiological studies showed that these mice showed significant brain atrophy and loss of hippocampal neurons. The researchers also showed that the two-week pulse of p25 did not cause neurodegeneration and had long-lasting effects on enhancing memory.
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
7-Dec-2005


Page: 1 2

Related biology news :

1. Nobel Laureate finds elegant explanation for DNA transcribing enzymes high fidelity
2. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
3. Link identified between Alzheimers disease and glaucoma
4. UCF research links proteins, stem cells and potential Alzheimers treatment
5. Journal of Alzheimers Disease achieves significant impact factor
6. Alzheimers prevention role discovered for prions
7. Cloned pigs help scientists towards a breakthrough in Alzheimers
8. Alzheimers drug based on Purdue -- designed inhibitor begins clinical trials
9. Paving the way toward a vaccine against Alzheimers disease
10. Genetic fellow traveler discovered in Alzheimers
11. New clues to stroke role in Alzheimers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... May 05, 2016 , ... ... support the National Stroke Association during National Stroke Awareness Month in May. ... Twitter pages throughout the month. CereScan will donate $1 up to a ...
(Date:5/4/2016)... ... 04, 2016 , ... Looking for a gift to give ... cooking experience. Offering everything from gourmet cooking classes to weekend culinary adventures, LaJollaCooks4u ... Guests that visit LaJollaCooks4u share an experience unlike any other. Each class takes ...
(Date:5/4/2016)... ... 2016 , ... Proove Biosciences, Inc. , the commercial and research leader ... University . The partnership is designed to advance research in pain genetics in an ... pain. With the new agreement, researchers at Proove Biosciences are able to collaborate with ...
(Date:5/4/2016)...  Bayer today announced that a Phase III ... (regorafenib) tablets for the treatment of patients with ... endpoint of a statistically significant improvement in overall ... and safety of regorafenib in patients with HCC ... The safety and tolerability were generally consistent with ...
Breaking Biology Technology:
Cached News: