HOME >> BIOLOGY >> NEWS
A change of heart for MEF2A in coronary artery disease

Coronary artery disease (CAD) is one of the major killers in Western societies. Recently, mutations in a gene called MEF2A on chromosome 15 were reported to be causative of premature CAD. The authors of the report failed to find the mutation in a large number of control individuals and thus concluded that the MEF2A mutation was the cause of the CAD. Only a single family was observed to carry the putative mutation, however.

A new study appearing in the April 1 print issue of The Journal of Clinical Investigation overturns these findings. Len Pennacchio and colleagues from Lawrence Berkeley National Laboratory have sequenced the MEF2A gene in about 300 patients with premature coronary heart disease and fail to find any causative mutations.

The researchers do find the precise mutation (a 21 base pair deletion) that was previously reported to be causative of CAD, but in this new JCI study, this mutation was found in three control subjects who did not have CAD or any other coronary heart disease. Thus, the studies demonstrate that MEF2A mutations are not common cause of heart disease and suggest that another one of 93 genes in that area of chromosome 15 was responsible for heart disease in the original family. These data question the role of MEF2A in CAD.

In an accompanying commentary, David Altshuler and Joel Hirschhorn write, "the genetic evidence available to date does not demonstrate that these mutations play a causal role in CAD in humans.These [new] studies remind us that replication and multiplicity in human genetic research are critically important."


'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212 342-4159
Journal of Clinical Investigation
1-Apr-2005


Page: 1

Related biology news :

1. Climate change isolates Rocky Mountain butterflies
2. Climate change and permafrost thaw alter greenhouse gas emissions in northern wetlands
3. Acute sleep deprivation leads to changes in nighttime urine production for men and women
4. How cells change the pace of their steps
5. Arctic Observing Network as a tool for understanding Arctic change
6. Climate change reduces Queenslands bat numbers
7. Marine phytoplankton changes form to protect itself from different predators
8. ENCODE map changes view of the human genome landscape
9. Salty oceans provide early warning for climate change
10. Study warns climate change and deforestation will lead to declines in global bird diversity
11. Smithsonian scientists connect climate change, origins of agriculture in Mexico

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... development services, today announced that the company has received ISO9001:2015 certification for ... diagnostics, and research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s ...
(Date:6/23/2020)... ... , ... In its June 22 online post, business and technology news platform ... Ph.D., founder and director of stem cell biotechnology company Asymmetrex . Superb Crew ... starting July 5 it would begin offering free tissue stem cell counting ...
(Date:6/13/2020)... , ... June 11, 2020 , ... ... services, announces a significant expansion of its forensic genealogy team. Bode’s Forensic ... attorneys through proven forensic genealogy and DNA analysis methods. The team has added ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... and Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing ... announced that they have entered into a strategic partnership whereby Catalent will provide ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... top radiation centers in 16 countries, has reached its 20th anniversary of worldwide ... in routine use at top universities including University of Pennsylvania, University of Michigan, ...
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver ... “It’s the only technology of its kind on the market and we were pleased ... the protective capacity of traditional cultured ingredients, creating a natural way to extend the ...
Breaking Biology Technology:
Cached News: