HOME >> BIOLOGY >> NEWS
A cytokine not kind to an injury of the spine

Transverse Myelitis (TM) is an autoimmune inflammatory disease of the central nervous system that is characterized by focal spinal cord demyelination and axonal injury. TM causes paralysis and other neurologic disabilities, but has limited treatment options due to a lack of understanding of its underlying mechanisms.

In a paper appearing online on September 22 in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Douglas Kerr and colleagues from Johns Hopkins find that levels of the cytokine IL-6 are selectively increased in cerebrospinal fluid from TM patients. The researchers show that elevated IL-6 levels alone are necessary and sufficient to mediate injury to both neuronal and glial cells, in a manner that is dependent on nitric oxide.

This is the first description of IL-6 as a mediator of neural injury. Further, high levels of IL-6 were directly correlated with tissue injury and clinical disability, suggesting that IL-6 may be an important biomarker of TM. This new data may aid in the development of effective therapies against TM and other inflammatory diseases of the central nervous system.


'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
22-Sep-2005


Page: 1

Related biology news :

1. The cytokine diet: The next fad in weight loss?
2. University of Cincinnati receives $1.7M to research molecular treatment of brain injury
3. Stem cells decrease ischemic injury and restore brain function
4. Deflecting damage: Flexible electronics aid brain injury research
5. Estrogen protects liver after traumatic injury
6. Uric acid and spinal cord injury treatment
7. Cell death following blood reflow injury tracked to natural toxin
8. Key to acute lung injury lies in Ang2 protein
9. In young rats, researchers find a reaction to spinal cord injury that speeds recovery
10. How brain injury leads to seizures, memory problems
11. Spinal cord bridge bypasses injury to restore mobility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... ... May 16, 2017 , ... ... its global Genedata Screener User Group Meetings, which will be held ... opportunity to share best practices in screening data analysis and learn about the ...
(Date:5/16/2017)... ... May 16, 2017 , ... ... diagnostics, has released its ClearID Lung Cancer blood test. Leveraging a highly-sensitive next-generation ... new test is designed to quickly and accurately identify tumor-related genetic mutations that ...
(Date:5/16/2017)... ... May 16, 2017 , ... On Tuesday, May 23 at 10:30 AM, James ... advance in stem cell medicine that his company has recently achieved in collaboration with ... the Alliance for Regenerative Medicine’s first partnering conference, Cell & Gene Exchange 2017 ...
(Date:5/15/2017)... ... May 15, 2017 , ... Algenist ... Lift Contouring Cream, a gravity-shattering cream with a patented formula, clinically proven to ... bring the Advanced Lift Contouring Cream to our already innovative ELEVATE product line,” ...
Breaking Biology Technology:
Cached News: