HOME >> BIOLOGY >> NEWS
A cytokine not kind to an injury of the spine

Transverse Myelitis (TM) is an autoimmune inflammatory disease of the central nervous system that is characterized by focal spinal cord demyelination and axonal injury. TM causes paralysis and other neurologic disabilities, but has limited treatment options due to a lack of understanding of its underlying mechanisms.

In a paper appearing online on September 22 in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Douglas Kerr and colleagues from Johns Hopkins find that levels of the cytokine IL-6 are selectively increased in cerebrospinal fluid from TM patients. The researchers show that elevated IL-6 levels alone are necessary and sufficient to mediate injury to both neuronal and glial cells, in a manner that is dependent on nitric oxide.

This is the first description of IL-6 as a mediator of neural injury. Further, high levels of IL-6 were directly correlated with tissue injury and clinical disability, suggesting that IL-6 may be an important biomarker of TM. This new data may aid in the development of effective therapies against TM and other inflammatory diseases of the central nervous system.


'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
22-Sep-2005


Page: 1

Related biology news :

1. The cytokine diet: The next fad in weight loss?
2. University of Cincinnati receives $1.7M to research molecular treatment of brain injury
3. Stem cells decrease ischemic injury and restore brain function
4. Deflecting damage: Flexible electronics aid brain injury research
5. Estrogen protects liver after traumatic injury
6. Uric acid and spinal cord injury treatment
7. Cell death following blood reflow injury tracked to natural toxin
8. Key to acute lung injury lies in Ang2 protein
9. In young rats, researchers find a reaction to spinal cord injury that speeds recovery
10. How brain injury leads to seizures, memory problems
11. Spinal cord bridge bypasses injury to restore mobility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/17/2016)... 2016  AIC announces that it has just released a new white paper authored ... scale-out plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system ...
(Date:11/15/2016)... Research and Markets has announced the addition ... report to their offering. ... The global ... from USD 6.21 Billion in 2016, growing at a CAGR of ... bioinformatics market is driven by the growing demand for nucleic acid ...
(Date:6/27/2016)... , June 27, 2016 Research and ... North America 2016-2020" report to their offering. ... North America to grow at a CAGR of ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... ... 2016 , ... Lajollacooks4u, San Diego’s premier team building events and cooking events ... program offerings and company expansion. , This is largely due to its ... over 30 people. Ever since, Lajollacooks4u has seen significant demand for its services from ...
(Date:12/8/2016)... ... December 08, 2016 , ... From wearable devices that can ... sports. On Thursday, December 15th a panel of entrepreneurs, innovators and a Philadelphia ... at a Smart Talk session. Smart Talk will run from 8:30 – 10:30 ...
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire/ ... presented demonstrating the role of the Breast Cancer ... stage, ER+ breast cancer are most at-risk for ... therapy. Data include results from three studies advancing ... provide information related to tumor biology and inform ...
(Date:12/8/2016)... Dec. 8, 2016 Eurofins announces the appointment of ... of Eurofins Scientific Inc. (ESI). Mr. Murray will ... professional and entrepreneurial experience in leading international business teams. As the ... testing market to uphold Eurofins, status as the global leader in ... , ...
Breaking Biology Technology:
Cached News: