HOME >> BIOLOGY >> NEWS
A faster way to recover from chemotherapy and marrow transplant

Researchers at Childrens Hospital Boston report finding a new way to increase stem cells in blood, suggesting a possible treatment to help patients who undergo chemotherapy or bone marrow transplant for leukemia and other cancers recover their immune function more quickly. In the June 21 issue of Nature, they demonstrate that a stable analog of prostaglandin can enhance the blood-forming system, both during embryonic development and after its been damaged.

The discovery, made possible through high-volume drug screening in zebrafish, marks the first time stem-cell production has been induced by a small-molecule drug, says the studys senior author, Leonard Zon, MD, of the Childrens Hospital Boston Stem Cell Program and Division of Hematology/Oncology. Other studies, including one from Zon's own lab*, have identified ways of increasing formation of blood stem cells, which give rise to each of the bodys various blood cell types. However, the methods are technically complex and havent lent themselves to broad medical use.

The hospital now hopes to conduct a clinical trial of the drug, a long-active derivative of prostaglandin E2 known as dmPGE2. This compound was originally tested more than 20 years ago for patients with gastritis, but was never marketed as a drug.

Currently, patients undergoing bone marrow transplant must wait for marrow from a matched donor to replenish their stem cells and reproduce the full array of blood cell types, including all the cells of the immune system. When theres no suitable donor for a marrow match, patients can receive umbilical cord blood, which also contains blood stem cells. But the number of stem cells in one cord of blood is often not adequate for older children and adults, leaving them with diminished immune function and high risk for infections.

Zon and colleagues Trista North, PhD, and Wolfram Goessling, MD, PhD, both also of Childrens Stem Cell Program, zeroed in on dmPGE2 by screeni
'"/>

Contact: Anna Gonski
anna.gonski@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
20-Jun-2007


Page: 1 2 3

Related biology news :

1. New grants bolster efforts to generate faster and cheaper tools for DNA sequencing
2. Journal of Nuclear Medicine releases new research faster
3. Cheaper, better disease treatments expected from faster approach to developing antibodies
4. Laser goes tubing for faster body-fluid tests
5. Cold is hot in evolution -- UBC researchers debunk belief species evolve faster in tropics
6. Does evolution select for faster evolvers?
7. Radiation degrades nuclear waste-containing materials faster than expected
8. Professional fasters deep under the sea floor
9. Have traits, will travel: Some butterflies travel farther, reproduce faster
10. NHGRI aims to make DNA sequencing faster, more cost effective
11. Wounds may one day heal better, faster, due to new NIH-funded wound healing centers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology ... object recognition technologies, today announced the release of ... (SDK), which provides improved facial recognition using up ... on a single computer. The new version uses ... improve accuracy, and it utilizes a Graphing Processing ...
(Date:3/22/2017)... Vigilant Solutions , a vehicle location ... announced today the appointment of retired FBI special agent ... business development. Mr. Sheridan brings more than ... focus on the aviation transportation sector, to his new ... Sheridan served as the Aviation Liaison Agent Coordinator (ALAC) ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... May 17, 2017 , ... ... stress expertise, and further enhances its scientific power by providing investigators access ... Ph.D., has agreed to join the scientific advisory board. “We are committed ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... business process optimization firm for the life sciences and healthcare industries, is honored ... and Traceability for Medical Devices conference in Brussels, Belgium. , Crowley played a ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... today that their Chief Executive Officer, Maik Jornitz, was recognized as a Top ... Power List celebrates 100 individuals “involved in bettering the pharma industry and bringing ...
(Date:5/18/2017)... ... ... was notified earlier this year that his company Asymmetrex had been selected as ... Review , he was not surprised as others might be. Sherley says, “I felt ... Valley was particularly meaningful. Our selection by The Silicon Review may seem ...
Breaking Biology Technology:
Cached News: