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A fisheye view of the deadliest breast cancer

y. While the parental MDA cells formed tightly packed aggregates, RhoC-overexpressing cells scattered within the fish tissue. RhoC overexpression also increased tumor cell membrane dynamics leading to continuous shedding of small cellular fragments.

The transparent fish also let the researchers make high-resolution 3D images of two potential anticancer compounds at work: a vascular endothelial growth factor (VEGF) receptor inhibitor called SU5416, and a protein kinase inhibitor called PP1. Analysis of compound and mock-treated animals revealed that SU5416 leads to shrinkage of tumor cells and tumor-induced vasculature, while PP1 mainly affects tumor cell survival.

In all, the researchers were delighted with their breast cancer models ability to work as a real-time study window into IBC tumor behavior and as a rapid screening system for anticancer drugs. In the race against aggressive breast cancers, Stoletov and colleagues see their xenografted, genetically engineered zebrafish as a potential front runner.


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Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
12-Dec-2006


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