HOME >> BIOLOGY >> NEWS
A form of the alcohol dehydrogenase gene may protect Afro-Trinidadians from developing alcoholism

  • Alcohol dehydrogenase (ADH) is one of the major enzymes involved in alcohol metabolism.
  • New findings indicate that the ADH1B*3 allele may protect against the development of alcoholism.
  • At the same time, the ADH1B*3 allele may be a risk factor for liver disease most likely because it increases levels of acetaldehyde if an individual with the allele does drink.

Alcohol dehydrogenase (ADH) is one of the major enzymes involved in alcohol metabolism. The genes for ADH are polymorphic at two loci, ADH1B and ADH1C. While the three alleles at the ADH1B locus have previously been linked with protection from alcohol dependence, a new study is the first to examine the relationship between the ADH1B*3 allele and alcohol-related disorders among Afro-Trinidadians. Findings indicate that while the ADH1B*3 allele appears to protect against alcoholism, it can also increase the risk for liver disease among those individuals who drink heavily.

Results are published in the February issue of Alcoholism: Clinical & Experimental Research.

"Alcohol is primarily metabolized or broken down in the liver by two enzymes," explained Cindy L. Ehlers, associate professor of molecular and integrative neuroscience at The Scripps Research Institute. "The first is ADH, which converts alcohol to acetaldehyde. Acetaldehyde is a toxic compound that can be damaging to the liver and other body organ systems. The second enzyme is aldehyde dehydrogenase (ALDH), which breaks down acetaldehyde to acetate, a relatively nontoxic compound."

Ehlers said that most people do not realize that people of different racial origins metabolize alcohol differently and that this influences their risk for alcoholism. "Approximately 40 percent of Asians have a mutation in ALDH that may cause them to have an aversive reaction when they drink so they are much less likely to develop alcohol dependence
'"/>


25-Jan-2007


Page: 1 2 3 4

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Females more prone to brain damage from alcohol abuse
3. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
4. Eat fish -- especially if you drink high levels of alcohol
5. Gene variant increases risk for alcoholism following childhood abuse
6. Spouse may drive you to drink but also can protect you from alcohol
7. Hot flashes -- Studies explore the role of genes, obesity and alcohol
8. Spousal choices can influence the risk of developing alcoholism
9. Sequence variation in the alpha synuclein gene contributes to alcohol craving
10. Cholesterol could be key to treating fetal alcohol syndrome
11. New compound prevents alcoholic behavior, relapse in animals by blocking stress response

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... , June 22, 2016  The American College of Medical ... Show Executive Magazine as one of the fastest-growing trade ... 25-27 at the Bellagio in Las Vegas ... highest percentage of growth in each of the following categories: ... companies and number of attendees. The 2015 ACMG Annual Meeting ...
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
(Date:6/22/2016)... On Monday, the Department of Homeland Security ... solutions for the Biometric Exit Program. The Request for ... (CBP), explains that CBP intends to add biometrics to ... United States , in order to deter visa ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... on what they believe could be a new and helpful biomarker for malignant ... Click here to read it now. , Biomarkers are components in ...
(Date:6/27/2016)... ... 2016 , ... Parallel 6 , the leading software as a service ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication ... , Using the CONSULT module, patients and physicians can schedule a face to face ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/27/2016)... Hill, N.C. (PRWEB) , ... June 27, 2016 ... ... U.S. commercial operations for Amgen, will join the faculty of the University ... serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a ...
Breaking Biology Technology:
Cached News: