HOME >> BIOLOGY >> NEWS
A form of the alcohol dehydrogenase gene may protect Afro-Trinidadians from developing alcoholism

  • Alcohol dehydrogenase (ADH) is one of the major enzymes involved in alcohol metabolism.
  • New findings indicate that the ADH1B*3 allele may protect against the development of alcoholism.
  • At the same time, the ADH1B*3 allele may be a risk factor for liver disease most likely because it increases levels of acetaldehyde if an individual with the allele does drink.

Alcohol dehydrogenase (ADH) is one of the major enzymes involved in alcohol metabolism. The genes for ADH are polymorphic at two loci, ADH1B and ADH1C. While the three alleles at the ADH1B locus have previously been linked with protection from alcohol dependence, a new study is the first to examine the relationship between the ADH1B*3 allele and alcohol-related disorders among Afro-Trinidadians. Findings indicate that while the ADH1B*3 allele appears to protect against alcoholism, it can also increase the risk for liver disease among those individuals who drink heavily.

Results are published in the February issue of Alcoholism: Clinical & Experimental Research.

"Alcohol is primarily metabolized or broken down in the liver by two enzymes," explained Cindy L. Ehlers, associate professor of molecular and integrative neuroscience at The Scripps Research Institute. "The first is ADH, which converts alcohol to acetaldehyde. Acetaldehyde is a toxic compound that can be damaging to the liver and other body organ systems. The second enzyme is aldehyde dehydrogenase (ALDH), which breaks down acetaldehyde to acetate, a relatively nontoxic compound."

Ehlers said that most people do not realize that people of different racial origins metabolize alcohol differently and that this influences their risk for alcoholism. "Approximately 40 percent of Asians have a mutation in ALDH that may cause them to have an aversive reaction when they drink so they are much less likely to develop alcohol dependence
'"/>


25-Jan-2007


Page: 1 2 3 4

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Females more prone to brain damage from alcohol abuse
3. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
4. Eat fish -- especially if you drink high levels of alcohol
5. Gene variant increases risk for alcoholism following childhood abuse
6. Spouse may drive you to drink but also can protect you from alcohol
7. Hot flashes -- Studies explore the role of genes, obesity and alcohol
8. Spousal choices can influence the risk of developing alcoholism
9. Sequence variation in the alpha synuclein gene contributes to alcohol craving
10. Cholesterol could be key to treating fetal alcohol syndrome
11. New compound prevents alcoholic behavior, relapse in animals by blocking stress response

Post Your Comments:
(Date:2/12/2015)... 12, 2015   MedNet Solutions , a ... study management systems, has recently bolstered its ... iMedNet as the eClinical ... and healthcare consultants.  Building on the Program,s existing ... and numerous co-marketing opportunities), MedNet,s new and improved ...
(Date:2/9/2015)... , Feb. 9, 2015  Lintec of America ... methods for carbon nanotube (CNT) macrostructures, including sheets, yarns ... Dallas (UTD). Leveraging the vast industrial resources ... Tokyo, Japan , Lintec of America is forming ... Richardson, TX , focusing on scaling up the ...
(Date:2/5/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces ... ) as part of its 2015 marketing and branding ... its new consumer website for Wocketwallet.com earlier this month. ... NXT-ID said, "Our new corporate website naturally showcases our ...
Breaking Biology News(10 mins):MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3
(Date:3/3/2015)... , March 3, 2015  Thingee Corporation, a ... be delivering a presentation entitled, "Technology Adoption: Making Reps, ... Thriving through Innovations and Technology ,  in ... 11 to 13, 2015. Audiences looking to learn how ... will want to be in the audience for the ...
(Date:3/3/2015)... 2015 AtheroNova Inc. (OTCQB: AHRO) today announced that ... petitions under Chapter 11 of the U.S. Bankruptcy Code in ... , Santa Ana division (the ... cases are expected to be jointly administered. The ... asset sale process, for all or substantially all of its ...
(Date:3/3/2015)... 03, 2015 Becht Engineering Co., ... it has acquired The CECON Group, Inc., located ... were not announced. , Becht Engineering (http://www.becht.com ... sector including oil and gas production, refining, petrochemical, ... nuclear power sectors. The company has twelve offices ...
(Date:3/3/2015)... March 03, 2015 Cambridge Semantics, the ... Web technology, today announced that it has been named ... Matter in Knowledge Management.’ , To create the ... colleagues, analysts and system integrators who identify organizations dedicated ... the right information to the right people at the ...
Breaking Biology Technology:Thingee to present at 11th Annual Synergistix Users Conference 2AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 2AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 3AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 4Cambridge Semantics Named to KMWorld’s 2015 ‘100 Companies That Matter in Knowledge Management’ 2
Cached News: