HOME >> BIOLOGY >> NEWS
A global view of gene expression in the aging kidney

Four years ago in Science, Stuart Kim, a Stanford University developmental biologist, made the case for describing the broad strokes of a complex physiological process before defining its mechanisms. "A powerful, top-down, holistic approach," he wrote, "is to identify all of the components of a particular cellular process, so that one can define the global picture first and then use it as a framework to understand how the individual components of the process fit together." To get a broad view of gene expression in the developing nematode, Kim's lab turned to DNA microarray technology. In a new study, Kim and colleagues apply this same approach to the decidedly more complex problem of human aging and "present a molecular portrait" of the aging kidney.

Kidneys came from 74 patients, ranging in age from 27 to 92. Samples were extracted from donated kidneys or "meticulously harvested" from kidneys with localized disease to ensure only normal tissue was taken. Samples were obtained from two structures that are critical to kidney function: the renal cortex, which filters plasma, and the medulla, which alters urine composition to maintain fluid balance. Both deteriorate with age.

Kim and colleagues then used DNA microarrays to determine the activity of every gene in all the kidney samples. Of 33,000 known human genes on the microarray, 985 showed age-related changes.

Although cortex and medulla have different cell types and perform different functions, their genetic aging profile was very similar, suggesting a common aging mechanism operates in both structures. In fact, these mechanisms may function broadly, as most of the age-regulated kidney genes were also active in a wide range of human tissues. Other organisms appear to lack these changes, however, prompting the authors to argue that understanding aging in humans will require human subjects.

Most importantly, the genetic profile of the tissue samples c
'"/>

Contact: Paul Ocampo
pocampo@plos.org
1-415-624-1224
Public Library of Science
29-Nov-2004


Page: 1 2

Related biology news :

1. Revolutionary global environment fund announces $50M expansion
2. 1,000-year-old Arctic ponds disappearing due to global warming
3. Desertification: UN experts prescribe global policy overhaul to avoid looming mass migrations
4. Scientists call for global push to advance research in synthetic biology
5. Northern forests less effective than tropical forests in reducing global warming
6. UN issues analysis of global investors sustainable energy gold rush
7. Gannet population under threat from global warming
8. Yale journal examines the global impact of cities
9. Researchers examine carbon capture and storage to combat global warming
10. QUT microgravity tower attracts global scientific community
11. Study warns climate change and deforestation will lead to declines in global bird diversity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... June 9, 2016 Paris ... Teleste,s video security solution to ensure the safety of people ... during the major tournament Teleste, an international ... and services, announced today that its video security solution will ... to back up public safety across the country. The system ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
Breaking Biology Technology:
Cached News: