HOME >> BIOLOGY >> NEWS
A global view of gene expression in the aging kidney

Four years ago in Science, Stuart Kim, a Stanford University developmental biologist, made the case for describing the broad strokes of a complex physiological process before defining its mechanisms. "A powerful, top-down, holistic approach," he wrote, "is to identify all of the components of a particular cellular process, so that one can define the global picture first and then use it as a framework to understand how the individual components of the process fit together." To get a broad view of gene expression in the developing nematode, Kim's lab turned to DNA microarray technology. In a new study, Kim and colleagues apply this same approach to the decidedly more complex problem of human aging and "present a molecular portrait" of the aging kidney.

Kidneys came from 74 patients, ranging in age from 27 to 92. Samples were extracted from donated kidneys or "meticulously harvested" from kidneys with localized disease to ensure only normal tissue was taken. Samples were obtained from two structures that are critical to kidney function: the renal cortex, which filters plasma, and the medulla, which alters urine composition to maintain fluid balance. Both deteriorate with age.

Kim and colleagues then used DNA microarrays to determine the activity of every gene in all the kidney samples. Of 33,000 known human genes on the microarray, 985 showed age-related changes.

Although cortex and medulla have different cell types and perform different functions, their genetic aging profile was very similar, suggesting a common aging mechanism operates in both structures. In fact, these mechanisms may function broadly, as most of the age-regulated kidney genes were also active in a wide range of human tissues. Other organisms appear to lack these changes, however, prompting the authors to argue that understanding aging in humans will require human subjects.

Most importantly, the genetic profile of the tissue samples c
'"/>

Contact: Paul Ocampo
pocampo@plos.org
1-415-624-1224
Public Library of Science
29-Nov-2004


Page: 1 2

Related biology news :

1. Revolutionary global environment fund announces $50M expansion
2. 1,000-year-old Arctic ponds disappearing due to global warming
3. Desertification: UN experts prescribe global policy overhaul to avoid looming mass migrations
4. Scientists call for global push to advance research in synthetic biology
5. Northern forests less effective than tropical forests in reducing global warming
6. UN issues analysis of global investors sustainable energy gold rush
7. Gannet population under threat from global warming
8. Yale journal examines the global impact of cities
9. Researchers examine carbon capture and storage to combat global warming
10. QUT microgravity tower attracts global scientific community
11. Study warns climate change and deforestation will lead to declines in global bird diversity

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: global view gene expression the aging kidney

(Date:10/25/2014)...   MedNet Solutions , a global life sciences ... pleased to announce the 2014 iMedNet User ... held in Bloomington, Minnesota on ... attendance and promises to be informative, productive and enjoyable ... the meeting is iMedNet™ EDC , ...
(Date:10/25/2014)... , Oct. 22, 2014 This report ... a relatively new space in heavy pursuit of research ... unique to miRNAs compared to other RNA components. miRNA,s ... it a novel candidate for use as a biomarker ... of miRNA-based microarrays and diagnostics for the advancement in ...
(Date:10/25/2014)... -- A recent report, "Genetic Testing Market Outlook 2018", ... genetic testing market. A comprehensive introduction of gene-based tests, ... report. On account of our analysis of the past ... challenges; forecast for genetic testing has been drawn, according ... a CAGR of around 9% during 2013-2018. Our ...
Breaking Biology News(10 mins):MedNet Solutions To Host Third Annual iMedNet User Group Meeting 2MicroRNA: An Insight to miRNA-based microarrays, diagnostics and therapeutics Overview, Cambridge Healthtech Advisors 2Genetic Testing Market Outlook 2018 2
(Date:10/25/2014)... NEW YORK , Oct. 24, ... formerly Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical company ... has implemented a 1-for-50 reverse split of its ... on Friday, October 24, 2014. PlasmaTech,s common stock ... CUSIP number 72754H109 and temporary ticker symbol "ACCPD". ...
(Date:10/25/2014)... 24, 2014 ... has announced the addition of the  "The ... Other 2-D Nanomaterials "  report to their ... ,CNTs and graphene are the strongest, lightest ... with a performance-per-weight greater than any other ...
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market ... in Americas with analysis and forecast of revenue. ... Inorganic Refrigerants Market report, to get an idea ... a glimpse of the segmentation in the Americas ... tables and figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html ...
(Date:10/22/2014)... NJ (PRWEB) October 22, 2014 ... and services – has been working with a team ... and New Haven Farms Community Farming Collaborative to provide ... ePRO solution. The study, which started in May, ... program that provides participants weekly exposure to and participation ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
Cached News: