A large step forward in the fight against African sleeping sickness

Each year, over 300,000 people die of African sleeping sickness (trypanosomiasis). Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the Free University of Brussels are making strides in the battle against this disease. They have coupled the human protein ApoL-1 with a nanobody in order to very specifically eliminate the infection caused by the pathogenic parasites, against which our defense mechanism is powerless. Tests on mice are already promising. The recently published research results offer new possibilities for people who have contracted this disease. >African sleeping sickness
About 400,000 people worldwide suffer from the deadly African sleeping sickness. The disease produces severe sleep disorders that ultimately end in coma, followed by death. At present, fewer than 10% of the patients are treated in time. But on the other hand, the current treatment is also very toxic, and in many cases also results in the patient's death.

African sleeping sickness is a disorder caused by the trypanosome parasite. The blood-sucking tsetse fly transmits the parasite from person to person. Once someone has been infected by the parasite, the person's body has great difficulty getting the infection under control, because the parasite constantly changes appearance. Thus, the trypanosome remains impervious to the antibodies that the body produces.

Parasite eludes human defense mechanism
Fortunately, our body has a special defense mechanism that can help us in the fight against African trypanosomes. Our blood contains ApoL-1, which is toxic to − and neutralizes − most types of trypanosomes.

However, there is one trypanosome against which we are not protected: Trypanosoma brucei rhodesiense. This parasite is resistant to ApoL-1, because it has particular proteins that counteract ApoL-1's action.

For some time now, scientists have known that a variant of ApoL

Contact: Joke Comijn
VIB, Flanders Interuniversity Institute of Biotechnology

Page: 1 2

Related biology news :

1. Ability to listen to 2 things at once is largely inherited, says twin study
2. Link between obesity and enlarged heart discovered by University of Arizona researchers
3. Giant magnetocaloric materials could have large impact on the environment
4. Reproductive speed protects large animals from being hunted to extinction
5. Landmark study identifies large number of new proteins implicated in Huntingtons disease
6. Developed/emerging market biotech firms convene at largest-ever meeting with global health focus
7. Obtaining valid consent for doing large genetic studies in developing countries
8. Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
9. Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply
10. Why are male antlers and horns so large?
11. Biologists develop large gene dataset for rice plant

Post Your Comments:

(Date:11/19/2015)... -- Although some 350 companies are actively involved in molecular ... according to Kalorama Information. These include Roche Diagnostics, Hologic, Abbott ... of the 6.1 billion-dollar molecular testing market, according to ... Diagnostic s .    ... one company and only a handful of companies can ...
(Date:11/17/2015)... Paris , qui ... Paris , qui s,est tenu du ... leader de l,innovation biométrique, a inventé le premier scanner ... sur la même surface de balayage. Jusqu,ici, deux scanners ... les empreintes digitales. Désormais, un seul scanner est en ...
(Date:11/12/2015)... 2015  A golden retriever that stayed healthy despite ... has provided a new lead for treating this muscle-wasting ... Institute of MIT and Harvard and the University of ... Cell, pinpoints a protective gene that ... effects. The Boston Children,s lab of Lou Kunkel ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 2015 --> ... "Oligonucleotide Synthesis Market by Product & Services (Primer, Probe, ... DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) ... market is expected to reach USD 1,918.6 Million by ... CAGR of 10.1% during the forecast period. ...
(Date:11/24/2015)... 24, 2015 SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> SHPG ... will participate in the Piper Jaffray 27 th Annual Healthcare ... Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ...
(Date:11/24/2015)... CITY , Nov. 24, 2015 /PRNewswire/ - ... "Company") announced today that the remaining 11,000 post-share ... Share Purchase Warrants (the "Series B Warrants") subject ... were exercised on November 23, 2015, which will ... Shares.  After giving effect to the issuance of ...
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier of ... has promoted Melanie Aregger to serve as Chief Operating Officer. , Having ... management team and was promoted to Head of InSphero Diagnostics in 2014. ...
Breaking Biology Technology:
Cached News: