HOME >> BIOLOGY >> NEWS
A new brake on cellular energy production discovered

A condition that has to be met for the body to be able to keep warm, move and even survive is that the mitochondria - the cells' power stations - release the right amounts of energy. Scientists at Karolinska Institutet have now identified the first known factor that acts as a brake on cellular energy production.

Mitochondria release energy through a process known as cellular respiration - a chemical process inside each mitochondrion that results in the production of the cell's energy currency, the molecule ATP.

As important parts of the respiratory chain are encoded by mitochrondrial DNA, mtDNA, the cell can adapt its energy production to varying needs by increasing or reducing the expression of mtDNA. However, very little is known about how this process is regulated.

Two research teams at Karolinska Institutet, led by Claes Gustafsson and Nils-Gran Larsson respectively, have now made an important breakthrough by discovering an entirely new mitochondrial factor, MTERF3. This new factor inhibits the expression of mtDNA and can thus slow down the cell's energy production.

The discovery, which is published in the journal Cell, may in future lead to completely new ways of treating various diseases. Impaired mitochondrial function gives rise to a cellular energy crisis and probably plays an important role in a number of common diseases such as diabetes, heart failure and Parkinsons disease, as well as in normal ageing.


'"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
27-Jul-2007


Page: 1

Related biology news :

1. Molecular motors and brakes work together in cells
2. PTEN: the Tregs handbrake
3. Molecular brake found for neurofibromatosis 1
4. New brain hormone puts brakes on reproduction
5. New understanding of cell movement may yield ways to brake cancers spread
6. New component of the brakes on nerve regeneration found
7. Unlocking proteins from their cellular shell
8. MNI researchers find a new role for mitochondria in cellular copper regulation
9. Unicellular microRNA discovery
10. Stem cell identity in culture may strongly depend on the cellular microenvironment
11. UNC scientists discover cellular SOS signal in response to UV skin damage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... antibody development services, today announced that the company has received ISO9001:2015 certification ... pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation demonstrates ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku Corporation , ... event in a series of TOPIQ webinars, which will cover the Transferable Aspherical ... developed in response to social distancing measures that resulted in postponements and cancelations ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... for Data Decisions,” for pharmaceutical and biotech executives, laboratory managers, scientists, researchers ... scientific instruments and laboratory equipment from dozens of manufacturers into their lab. ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 2020 , ... R3 Stem Cell International is now offering patients the opportunity ... cells total, patients may choose which extremities they would like treated. , Several studies ... Disord. 2016). At R3 International, umbilical cord tissue is obtained from a lab with ...
(Date:7/31/2020)... ... , ... eSource has long been touted as the solution to high data ... the reasons it did not take off as quickly as people initially expected, and ... moving towards capturing data electronically for clinical trials and then repurposing it for downstream ...
(Date:7/18/2020)... MILWAUKEE (PRWEB) , ... July 16, 2020 , ... “We ... at Third Wave Bioactives. “It’s the only technology of its kind on the market ... flavor of onions with the protective capacity of traditional cultured ingredients, creating a natural ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining ... research team led by Dr MA has been using the zebrafish model to ...
Breaking Biology Technology:
Cached News: