HOME >> BIOLOGY >> NEWS
A new kind of mutation could explain numerous phenotypic variations in various species

The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. In this study, the gene concerned is the myostatin. This gene is expressed in the skeletal muscle and the function of the derived protein is to inhibit muscular growth. The mutation discovered among sheep exposed a recognition site for two miRNAs that are highly expressed in the muscle. In "mutant" animals, these miRNAs will consequently target the myostatin gene and block its translation. The result is that the absence of myostatin provokes a muscular hypertrophy among Texel sheep.

A mechanism observed in other species as well

However, Michel Georges' team investigated further. Pursuing the study using bioinformatic approaches, the team identified polymorphisms (common mutations) among humans and mice that are likely to act in the same way as they do in the Texel breed. It appears, therefore, that this new kind of mutation, discovered while studying sheep, could contribute significantly to the phenotypic variation observed in many species among which humans including the hereditary predisposition to various diseases.

Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://www.patrocles.org). It will assist researchers around the world in discovering similar phenomena for other phenotypes including hereditary diseases.


'"/>

Contact: Prof. Michel GEORGES
michel.georges@ulg.ac.be
324-366-4151
University of Liege
5-Jun-2006


Page: 1

Related biology news :

1. New gene mutation identified in common type of dementia
2. Researchers identify genetic mutation that may alter tumor cell proliferation
3. p53 gene mutations and inflammation trigger skin cancer
4. Muscle weakness: New mutation identified
5. Researchers discover inherited mutation for leukemia
6. Gene mutation linked to cognition is found only in humans
7. Gene mutation linked to increased athletic performance in whippets
8. Researchers learn more about genetic mutation linked to autism
9. Researchers find gene mutation that causes infertility in male mice
10. Gene mutations linked to hereditary lung disease
11. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2018)... ... August 24, 2018 , ... ... tool in clinical diagnostic laboratories. However, this technology introduces many well-described challenges ... London, which leads the South London NHS Genomic Medicine Centre. The Viapath ...
(Date:8/23/2018)... ... 21, 2018 , ... CRISPR-Cas9 gene editing strategies have revolutionized ... the robust functional interrogation of complex biological processes. Gene editing in primary T-cells ... study of the autoimmunity, the understanding of host-pathogen dynamics that drive HIV replication ...
(Date:8/21/2018)... ... August 20, 2018 , ... When designing a ... consider. Designers must ensure what is designed can be manufactured reliably and cost ... practices in flow path design with specific focus on layered manifold technology. , ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... ... 28, 2018 , ... Cognition Corporation ®, a software company specializing in ... NAVIGATE2018 . , Ryan Ward, Director of Engineering at Zimmer Biomet, has been ... engineer and manager with Zimmer Biomet for almost 15 years, Mr. Ward will focus ...
(Date:8/29/2018)... ... August 28, 2018 , ... LabRoots , the leading provider ... is proud to announce the launch of a new gamification feature, allowing users to ... win one of LabRoots most popular shirts. , Throughout each month, LabRoots users will ...
(Date:8/26/2018)... ... August 24, 2018 , ... ... cell-derived exosomes dramatically relieves atopic dermatitis and inhibits a variety of inflammatory targets ... the paper, the symptoms of mice having severe atopic dermatitis were significantly improved ...
(Date:8/21/2018)... ... August 21, 2018 , ... ... device compliance and commercialization, has just released a new paper discussing systems ... by Dr. Mario Kossmann, ESEP at the 28th Annual INCOSE International Symposium, ...
Breaking Biology Technology:
Cached News: