HOME >> BIOLOGY >> NEWS
A new turn-on for genes

Researchers discovered a special type of molecular structure that helps keep genes properly turned off until the structure is ejected from those genes in a regulated manner to help turn the genes on.

The discovery is reported in the Oct. 21 issue of the journal Cell by scientists from the Huntsman Cancer Institute at the University of Utah.

In all organisms, the genome is split into chromosomes (compressed long strands of DNA) which are subdivided into functional DNA segments called genes. Genes function as the blueprints for building particular pieces of cellular machinery. However, different types of cells each require different types of cellular machinery, and must produce that machinery according to a biological timetable. A central issue in molecular biology is finding out how a cell regulates which genes are on, or active, and which genes are off, or repressed. This topic has direct relevance to human disease, as improper activation or repression of genes that regulate cellular growth is a common feature of cancer cells.

"We must understand how genes are activated or repressed in normal cells in order to understand how this process is misregulated in cancer cells," says Brad Cairns, Ph.D., lead scientist on the study and an investigator with Huntsman Cancer Institute. "We are beginning to understand how gene activation and repression is altered in cancer cells, and how that leads to tumor growth. However, the design of targeted treatments that can correct these alterations will require a deep knowledge of the basic cellular mechanisms that regulate gene expression."

The scientists studied a group of proteins known as histones, which form disk-like structures called nucleosomes when they are wrapped by genes. Under an electron microscope, the nucleosomes look like beads strung along the DNA strand. Normal nucleosomes block access to the cellular machinery that reads the blueprint stored in the gene, keeping the gene
'"/>


21-Oct-2005


Page: 1 2

Related biology news :

1. Interaction of just 2 genes governs coloration patterns in mice
2. Gene regulation, not just genes, is what sets humans apart
3. Study finds gender differences in renal and other genes contributing to blood pressure
4. New databases put wings on search for bipolar risk genes
5. Research teams uncover risk genes for multiple sclerosis
6. Risk genes for multiple sclerosis uncovered
7. Sour taste make you pucker? It may be in your genes
8. U-M, Israeli scientists report major advance in search for genes associated with colon cancer
9. Rapid evolution of defense genes in plants may produce hybrid incompatibility
10. Alcohol abuse is in the genes
11. St. Jude study shows genes play an unexpected role in their own activation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a ... 2020 annual Inc. 5000 list. The list is the most prestigious ranking of the ... well, and for this year’s list, reported three-year revenue growth of 71 percent. ...
(Date:8/21/2020)... ... August 19, 2020 , ... The ... uniting life science, data science, informatics and IT leaders goes VIRTUAL and announces ... of uncertainty and change, Bio-IT takes the leadership role of keeping our life ...
(Date:8/7/2020)... , ... August 06, 2020 , ... ... industry, is pleased to announce that Eric Chen and Jessica Wong have joined ... Product Management & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now ... With 50 million stem cells total, patients may choose which extremities they would like ... arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and ... it did not take off as quickly as people initially expected, and where eSource ... capturing data electronically for clinical trials and then repurposing it for downstream analysis, at ...
(Date:7/18/2020)... ... 16, 2020 , ... “We are thrilled to deliver this new technology to ... of its kind on the market and we were pleased that the IFT jury ... traditional cultured ingredients, creating a natural way to extend the shelf life and improve ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical ... team led by Dr MA has been using the zebrafish model to investigate ...
Breaking Biology Technology:
Cached News: