HOME >> BIOLOGY >> NEWS
A nurse makes the decision on who will live

Thymic nurse cells were given their name because of their intimate relationship with developing T cells (thymocytes) in the thymus. Thymic nurse cells have been reported to take as many as 50 thymocytes into their cell body (see thymocytes inside of a thymic nurse cell in photos, the blue dye stains the nuclei of thymocytes inside of a nurse cell). Whether or not thymic nurse cells have the capacity to "internalize" another cell into itself, and the function of this unique biological phenomenon during T cell development is the focus of studies performed by Dr. Guyden at The City College of New York and his colleagues at Tuskegee University.

Thymic nurse cells were discovered in 1980. Their existence was heavily debated because many scientists found it difficult to believe that a cell could internalize another cell. In early studies, it was suggested that thymic nurse cells function exclusively in the up-take and removal of non-functional thymocytes from the developmental process. In a study featured in the June issue of Experimental Biology and Medicine, Dr. Guyden and his colleagues show that thymic nurse cell function is not limited to the removal of non-functional thymocytes, but plays a role in deciding which thymocytes will die, because they will be potentially harmful if they mature, and which will continue to develop into normal T cells. These results were obtained using a genetically altered mouse system created to study this selection process, which is called MHC restriction. During MHC restriction, all potentially harmful thymocytes must be weeded out (a process called negative selection). The remaining normal subset of thymocytes is induced to mature (a process called positive selection). The genetic alteration in the animals studied results in female mice whose thymocytes undergo positive selection, exclusively, while all thymocytes in male mice are negatively selected. If thymic nurse cells only internalize thymocytes that will be
'"/>

Contact: Jerry Guyden
jguyden@ccny.cuny.edu
212-650-8449
Society for Experimental Biology and Medicine
23-May-2007


Page: 1 2

Related biology news :

1. UCI nurses receive $2.7 million to study exercise and impact on growth in premature babies
2. Preparing for the inevitable: New book for nurses guides patient care during a disaster
3. Altering a protein makes mice less fearful
4. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
5. Book makes case for using evolution in everyday life
6. Dartmouth professor makes case for ethically universal stem cell lines
7. NASA-funded robotic sub makes final dive to reach bottom of Earths deepest sinkhole
8. Personality-gene makes songbirds curious
9. Scientists unlock secret of what makes plants flower
10. Third primate genome, the rhesus macaque, helps illuminate what makes us human
11. Researchers figure out what makes a simple biological clock tick

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2020)... ... February 11, 2020 , ... The ... medical device accelerator in Port Covington, Baltimore. The newly formed company is developing ... addressed to manage increased demand for home dialysis treatments. The start-up company will ...
(Date:2/5/2020)... (PRWEB) , ... February 04, 2020 , ... ... Trademark Office (USPTO) issued the company a second patent related to proprietary liquid ... of Allowance compliments another patent from the USPTO issued on December 3, 2019. ...
(Date:1/29/2020)... (PRWEB) , ... January 29, 2020 , ... ... receptor and in vitro toxicology testing solutions, has announced a record earnings year ... upcoming weeks, INDIGO showed more than a twenty percent increase in revenue and ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... ... , ... The plastic and reconstructive surgeons at The Institute for Advanced ... that plastic surgery is much more than just cosmetic surgery and far more extensive ... 20 years NJ Top Docs, Dr. Andrew Elkwood, Dr. Michael Rose, Dr. Matthew Kaufman, ...
(Date:1/24/2020)... ... January 24, 2020 , ... ... RedySmart™ mass flow meters and controllers ideal for BioPharm OEMS. Sierra ... to antiquated rotameters. These thermal instruments employ high-precision MEMS (Micro-Electro Mechanical Systems) technology ...
(Date:1/22/2020)... MATEO, Calif. (PRWEB) , ... January 20, 2020 ... ... System, today announced a partnership with WAVE Electronics, the largest independent electronics distributor ... installer partners to purchase Brilliant Smart Home Systems with leading smart home products ...
(Date:1/22/2020)... ... January 21, 2020 , ... COBO Technologies and ... editing. The partners have agreed to co-develop and market a portfolio of CRISPR ... pre-clinical programs. Over the longer-term, the parties aim to develop a COBO branded ...
Breaking Biology Technology:
Cached News: