HOME >> BIOLOGY >> NEWS
A nurse makes the decision on who will live

Thymic nurse cells were given their name because of their intimate relationship with developing T cells (thymocytes) in the thymus. Thymic nurse cells have been reported to take as many as 50 thymocytes into their cell body (see thymocytes inside of a thymic nurse cell in photos, the blue dye stains the nuclei of thymocytes inside of a nurse cell). Whether or not thymic nurse cells have the capacity to "internalize" another cell into itself, and the function of this unique biological phenomenon during T cell development is the focus of studies performed by Dr. Guyden at The City College of New York and his colleagues at Tuskegee University.

Thymic nurse cells were discovered in 1980. Their existence was heavily debated because many scientists found it difficult to believe that a cell could internalize another cell. In early studies, it was suggested that thymic nurse cells function exclusively in the up-take and removal of non-functional thymocytes from the developmental process. In a study featured in the June issue of Experimental Biology and Medicine, Dr. Guyden and his colleagues show that thymic nurse cell function is not limited to the removal of non-functional thymocytes, but plays a role in deciding which thymocytes will die, because they will be potentially harmful if they mature, and which will continue to develop into normal T cells. These results were obtained using a genetically altered mouse system created to study this selection process, which is called MHC restriction. During MHC restriction, all potentially harmful thymocytes must be weeded out (a process called negative selection). The remaining normal subset of thymocytes is induced to mature (a process called positive selection). The genetic alteration in the animals studied results in female mice whose thymocytes undergo positive selection, exclusively, while all thymocytes in male mice are negatively selected. If thymic nurse cells only internalize thymocytes that will be
'"/>

Contact: Jerry Guyden
jguyden@ccny.cuny.edu
212-650-8449
Society for Experimental Biology and Medicine
23-May-2007


Page: 1 2

Related biology news :

1. UCI nurses receive $2.7 million to study exercise and impact on growth in premature babies
2. Preparing for the inevitable: New book for nurses guides patient care during a disaster
3. Altering a protein makes mice less fearful
4. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
5. Book makes case for using evolution in everyday life
6. Dartmouth professor makes case for ethically universal stem cell lines
7. NASA-funded robotic sub makes final dive to reach bottom of Earths deepest sinkhole
8. Personality-gene makes songbirds curious
9. Scientists unlock secret of what makes plants flower
10. Third primate genome, the rhesus macaque, helps illuminate what makes us human
11. Researchers figure out what makes a simple biological clock tick

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... (PRWEB) , ... August 05, 2019 , ... Keck Graduate ... KGI School of Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly regarded ... of Trustees Chairman Jim Widergren. “He is a great choice to build on the ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... and environmental concerns. One plant-based food in particular quickly entered the limelight – ... product developers use a thermogelling and emulsifying ingredient such as methyl cellulose. This ...
(Date:8/4/2019)... PRINCETON, N.J. (PRWEB) , ... August 02, 2019 ... ... expertise to assist the life science industry in advancing the development of medical ... has been recognized by PharmaVOICE magazine as one of the “100 Most Inspiring ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... 13, 2019 , ... INDIGO Biosciences, Inc. (INDIGO), the recognized ... appointment of Mark McLoughlin to the Company’s Board of Directors. Mark brings four ... his healthcare expertise and extensive background in laboratory and scientific products manufacturing, distribution, ...
(Date:8/6/2019)... ... August 06, 2019 , ... The San Diego Biotechnology ... the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech community and ... to promote the region and attract external employers, investors, scientists, and others who ...
(Date:8/4/2019)... MINNEAPOLIS (PRWEB) , ... August 02, 2019 , ... Cirtec ... minimally invasive devices, today announced that it has begun construction on a 30,000 sq. ... about 15 miles from San Jose. , The facility, which is expected to ...
(Date:7/19/2019)... ... 2019 , ... Global precision motion and piezo technology solutions ... facilities in Lederhose, Germany, increasing their current footprint by half again. , The ... addition to general office space, a significant increase to its existing 129,000ft² structure. ...
Breaking Biology Technology:
Cached News: