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A plastic pill for periodontal problems

NEW BRUNSWICK/PISCATAWAY, N.J. Rutgers scientists today announced a revolutionary new treatment for killing the bacteria that attack gum tissue during periodontal disease, while also promoting healing and the regeneration of tissue and bone around the teeth.

Eight to 12 percent of Americans have periodontal disease serious enough to require some type of advanced treatment, such as surgery. Left untreated, the condition can lead to tooth loss.

The breakthrough technology a polymer-based drug delivery system that may be implanted in pockets between the teeth and the gum developed at Rutgers, The State University of New Jersey, was presented at the 232nd National Meeting of the American Chemical Society in San Francisco by Michelle Johnson, a graduate student in the research group of paper co-author Kathryn Uhrich, a professor of chemistry and chemical biology at Rutgers.

"There has never been anything like this available to clinicians and it will certainly find a very prominent role in periodontal therapy in the future," said Mark Reynolds, chair of the department of periodontics at the University of Maryland Dental School, who collaborates with Uhrich on the research.

The new polymer or "plastic" material, when inserted between tooth and diseased gum, treats the bacterial infection, inflammation and pain with pharmaceuticals incorporated into the material itself, Johnson explained. It employs salicylic acid, the active ingredient in aspirin, for the swelling and discomfort, and three antimicrobials each with a different release rate compounds of clindamycin, chlorhexidrine and minocycline.

Once implanted, the polymer gradually breaks down to release the salicylic acid, which relieves pain and reduces inflammation, and the antimicrobials which inhibit infection at a sustained pace, Uhrich added.

Periodontal disease occurs when plaque that forms on the tooth surface spreads and grows below the gum line. Th
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Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x652
Rutgers, the State University of New Jersey
14-Sep-2006


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