HOME >> BIOLOGY >> NEWS
A powerful new tool for decoding gene functions in mammals and Man

New Haven, Conn. -- A collaborative project between American and Chinese researchers developed a way to study the function of genes in mice and man by using a moveable genetic element from moths, according to a report in the journal Cell.

"We know how many genes are in the mammalian genome, but that does not tell us how they carry out their jobs," said senior author Tian Xu, Professor and Vice Chair of Genetics at Yale University School of Medicine and a Howard Hughes Medical Institute Investigator. "We have found a way to systematically inactivate genes in the mouse genome so we can understand the functions of these genes."

After sequencing the human and mouse genomes, many scientists have shifted their attention to determining the function of all of those genes. The strategy is to mutate each gene, to observe the consequences, and investigate the molecular mechanisms. In the past two decades, only a small percentage of the genes shared by mice and humans have been analyzed in detail.

Genetic elements, called transposons, move from place to place in the DNA and allow material to be inserted or relocated. Bacteria swap antibiotic-resistance genes with transposons. Scientists have tailored this natural gene shuffling technique to insert genes and to mutate genes in fruit flies and simple organisms to learn the function of individual genes.

Transposons have proved to be valuable genetic tools for many organisms, but not for vertebrates and mammals. General application in mouse genetics was limited as they travel at low frequencies to limited locations, and had little capacity to carry DNA fragments.It tookXu's team six years to develop an efficient tool for genetic manipulations in vertebrates and mammals.

Xu and his colleagues at Fudan University in Shanghai, China finally chose a transposon called piggyBac that was originally identified in the cabbage looper moth. They discovered that it was stable and
'"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
12-Aug-2005


Page: 1 2 3

Related biology news :

1. Minuscule molecules pack a powerful punch
2. Junk DNA now looks like powerful regulator, Stanford researcher finds
3. A more powerful and efficient engine for rice: the C3-C4 challenge
4. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
5. Collaborative Cross to provide powerful resource for mouse model researchers worldwide
6. SciFinder 2006 launches powerful new substance search capablities
7. License to kill enables powerful immune attack cells in mice
8. Broccoli packs powerful punch to bladder cancer cells
9. Genes exert powerful effect on sexual behavior
10. STN AnaVist is powerful new analysis & visualization software
11. Mosaic mouse technique offers a powerful new tool to study diseases and genetics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: powerful new tool for decoding gene functions mammals and Man

(Date:4/23/2014)... a newly coined term for novels and films which focus ... of Copenhagen shows how these fictions serve as a mental ... climate change and imagine other living conditions. , "Global ... the atmosphere; it is also a cultural phenomenon in which ... the films we see. And there are so many of ...
(Date:4/23/2014)... at the University of Houston (UH) is working to ... His work is supported by a $1.8 million grant ... Blood transfusions save millions of lives every year. They ... for instance, routine surgeries would become life threatening. This ... that transfusions of red blood cells stored in a ...
(Date:4/22/2014)... There,s a new secret to get your child to behave ... , A new Cornell study published in Eating Behaviors ... they had to bite with their front teeth such as ... rowdier than when these foods had been cut. ... as aggressive toward other kids," said Brian Wansink, Professor and ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3UH biomedical engineer works to make blood transfusions safer 2UH biomedical engineer works to make blood transfusions safer 3Biting vs. chewing 2
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
(Date:1/15/2014)... 2014 DTS Language Services, Inc . ... Portal for Life Science organizations who need document translations. ... matter of their documents in advance with a selection of ... of translations, often a critical factor in clinical and scientific ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
Cached News: