HOME >> BIOLOGY >> NEWS
A powerful new tool for decoding gene functions in mammals and Man

New Haven, Conn. -- A collaborative project between American and Chinese researchers developed a way to study the function of genes in mice and man by using a moveable genetic element from moths, according to a report in the journal Cell.

"We know how many genes are in the mammalian genome, but that does not tell us how they carry out their jobs," said senior author Tian Xu, Professor and Vice Chair of Genetics at Yale University School of Medicine and a Howard Hughes Medical Institute Investigator. "We have found a way to systematically inactivate genes in the mouse genome so we can understand the functions of these genes."

After sequencing the human and mouse genomes, many scientists have shifted their attention to determining the function of all of those genes. The strategy is to mutate each gene, to observe the consequences, and investigate the molecular mechanisms. In the past two decades, only a small percentage of the genes shared by mice and humans have been analyzed in detail.

Genetic elements, called transposons, move from place to place in the DNA and allow material to be inserted or relocated. Bacteria swap antibiotic-resistance genes with transposons. Scientists have tailored this natural gene shuffling technique to insert genes and to mutate genes in fruit flies and simple organisms to learn the function of individual genes.

Transposons have proved to be valuable genetic tools for many organisms, but not for vertebrates and mammals. General application in mouse genetics was limited as they travel at low frequencies to limited locations, and had little capacity to carry DNA fragments.It tookXu's team six years to develop an efficient tool for genetic manipulations in vertebrates and mammals.

Xu and his colleagues at Fudan University in Shanghai, China finally chose a transposon called piggyBac that was originally identified in the cabbage looper moth. They discovered that it was stable and
'"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
12-Aug-2005


Page: 1 2 3

Related biology news :

1. Minuscule molecules pack a powerful punch
2. Junk DNA now looks like powerful regulator, Stanford researcher finds
3. A more powerful and efficient engine for rice: the C3-C4 challenge
4. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
5. Collaborative Cross to provide powerful resource for mouse model researchers worldwide
6. SciFinder 2006 launches powerful new substance search capablities
7. License to kill enables powerful immune attack cells in mice
8. Broccoli packs powerful punch to bladder cancer cells
9. Genes exert powerful effect on sexual behavior
10. STN AnaVist is powerful new analysis & visualization software
11. Mosaic mouse technique offers a powerful new tool to study diseases and genetics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... Chapel Hill, N.C. (PRWEB) , ... June 27, ... ... of U.S. commercial operations for Amgen, will join the faculty of the ... will serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
Breaking Biology Technology:
Cached News: