HOME >> BIOLOGY >> NEWS
A powerful new tool for decoding gene functions in mammals and Man

New Haven, Conn. -- A collaborative project between American and Chinese researchers developed a way to study the function of genes in mice and man by using a moveable genetic element from moths, according to a report in the journal Cell.

"We know how many genes are in the mammalian genome, but that does not tell us how they carry out their jobs," said senior author Tian Xu, Professor and Vice Chair of Genetics at Yale University School of Medicine and a Howard Hughes Medical Institute Investigator. "We have found a way to systematically inactivate genes in the mouse genome so we can understand the functions of these genes."

After sequencing the human and mouse genomes, many scientists have shifted their attention to determining the function of all of those genes. The strategy is to mutate each gene, to observe the consequences, and investigate the molecular mechanisms. In the past two decades, only a small percentage of the genes shared by mice and humans have been analyzed in detail.

Genetic elements, called transposons, move from place to place in the DNA and allow material to be inserted or relocated. Bacteria swap antibiotic-resistance genes with transposons. Scientists have tailored this natural gene shuffling technique to insert genes and to mutate genes in fruit flies and simple organisms to learn the function of individual genes.

Transposons have proved to be valuable genetic tools for many organisms, but not for vertebrates and mammals. General application in mouse genetics was limited as they travel at low frequencies to limited locations, and had little capacity to carry DNA fragments.It tookXu's team six years to develop an efficient tool for genetic manipulations in vertebrates and mammals.

Xu and his colleagues at Fudan University in Shanghai, China finally chose a transposon called piggyBac that was originally identified in the cabbage looper moth. They discovered that it was stable and
'"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
12-Aug-2005


Page: 1 2 3

Related biology news :

1. Minuscule molecules pack a powerful punch
2. Junk DNA now looks like powerful regulator, Stanford researcher finds
3. A more powerful and efficient engine for rice: the C3-C4 challenge
4. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
5. Collaborative Cross to provide powerful resource for mouse model researchers worldwide
6. SciFinder 2006 launches powerful new substance search capablities
7. License to kill enables powerful immune attack cells in mice
8. Broccoli packs powerful punch to bladder cancer cells
9. Genes exert powerful effect on sexual behavior
10. STN AnaVist is powerful new analysis & visualization software
11. Mosaic mouse technique offers a powerful new tool to study diseases and genetics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: powerful new tool for decoding gene functions mammals and Man

(Date:10/28/2014)... Health (NIH) announced awards to expand the Office ... Center for Advancing Translational Sciences (ORDR-NCATS) collaborative Rare ... network, physician scientists at 22 consortia will work ... research and investigate new treatments for patients with ... $29 million in fiscal 2014 funding from NIH. ...
(Date:10/28/2014)... in a novel environment are linked to individual ... experimental study completed at the University of Eastern ... Institute. The study used novel, long-term observations of ... to analyse if behaviours predict the vulnerability to ... enriched hatchery rearing environments. Based on the ...
(Date:10/28/2014)... associated with a lower risk of developing ovarian cancer, ... Anglia (UEA). , Research published today reveals that ... subclasses of dietary flavonoids) significantly decrease their risk of ... death among women. , The research team studied ... and 55 for more than three decades. , ...
Breaking Biology News(10 mins):NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 2NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 3Fish 'personality' linked to vulnerability to angling 2Tea and citrus products could lower ovarian cancer risk, new UEA research finds 2
(Date:10/30/2014)... October 30, 2014 2014 Deep ... Industryā€¯ is a professional and in-depth research report ... basic Naltrexone HCL information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:10/30/2014)... San Diego, CA (PRWEB) October 30, 2014 ... company announced today that they have manually curated public ... Pharma and non profit customers. the data is ... BioSciences manually curates and unifies public and internal data ... more value and knowledge out of the data that ...
(Date:10/30/2014)... New York, NY (PRWEB) October 30, 2014 ... investment plan for its ICH Stability Testing and Package ... companies, this investment centers on a dramatic increase in ... larger volume of stability, storage and aging samples to ... first stage of this major capital expenditure has already ...
(Date:10/30/2014)... , Oct. 30, 2014 Isis Pharmaceuticals, Inc. ... today announced that management will present a company overview at ... 8:30 a.m. ET in Boston, MA. ... available on the "Investors & Media" section of the Company,s ... the Isis website within 48 hours and will be archived ...
Breaking Biology Technology:Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Rancho BioSciences Manually Curated TCGA Data Sets Available 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2
Cached News: