HOME >> BIOLOGY >> NEWS
A real time look at interactions between RNA and proteins

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observein real-timethe intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions. Researchers at the University of Pennsylvania School of Medicine who developed the new technology see this advance as one of the next logical steps in genomics research. Senior author James Eberwine, PhD, Professor of Pharmacology at Penn, and colleagues published their research this week in the Proceedings of the National Academy of Sciences.

"Now we have a workable system to understand all aspects of RNA metabolism in a cell," say Eberwine. "For the first time, we can study how manipulation of cellular physiology, such as administering a drug, changes RNA-binding protein and RNA interactions. This technology allows us to see that in real time in real cells."

RNA is the genetic material that programs cells to make proteins from DNA's blueprint and specifies which proteins should be made. There are many types of RNA in the cells of mammals, such as transfer RNA, ribosomal RNA, and messenger RNAeach with a specific purpose in making and manipulating proteins.

The workhorses of the cell, RNA-binding proteins regulate every aspect of RNA function. Indeed, RNA is transported from one site to another inside the cell by RNA-binding proteins; RNA is translated into protein with the help of RNA-binding proteins, and RNA-binding proteins degrade used RNA. "They're really the master regulators of expression in the cell," says Eberwine.

Using whole neurons from rodents, the researchers were able to identify RNA interactions in live cells. In collaboration with lo Langel from Stockholm University, the Penn investigators devised a many-talented molecule that does not get broken down by enzymes once inside a live cell. One end of the molecule, called a peptide nucleic acid (PNA), has a
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
27-Jan-2006


Page: 1 2

Related biology news :

1. Protein interactions targets for Huntington disease therapy
2. Elastic interactions of membrane proteins
3. Penn leads $4 million grant to study gene-environment interactions in lung cancer
4. Microtubule protein interactions visualized en masse
5. Screening for complex genetic interactions
6. CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
7. NIH funding renewed for VA study of alcohol and HIV/AIDS interactions
8. Cold Spring Harbor Protocols features methods for analyzing protein interactions
9. Gene-on-gene interactions may influence risk for developing alcoholism
10. UAF hosts symposium on human-fire interactions
11. First comprehensive literature-derived database of yeast interactions

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
Breaking Biology Technology:
Cached News: