HOME >> BIOLOGY >> NEWS
A relative of anti-aging gene Klotho also influences metabolic activity, obesity

DALLAS April 23, 2007 -- A relative of the anti-aging gene Klotho helps activate a hormone that can lower blood glucose levels in fat cells of mice, making it a novel target for developing drugs to treat human obesity and diabetes, UT Southwestern Medical Center researchers have found.

In a study available online and in the Proceedings of the National Academy of Sciences, the researchers show that a type of Klotho protein binds to receptors for a metabolic hormone in fat cells, forming a "co-receptor" that enables the hormone to stimulate the processing of glucose, the bodys main source of fuel. The Klotho gene has previously been found to play a role in prolonging the life of mice partly by controlling insulin.

Mice lacking this particular Klotho protein cant stimulate this key metabolic activity, said Dr. Makoto Kuro-o, associate professor of pathology at UT Southwestern and the studys senior author.

"The ability to stimulate the glucose processing is key to proper metabolism, so this Klotho protein, known as beta-Klotho, is a novel target for developing drugs that can enhance or block the metabolic activity of this hormone, which has been shown to be able to lower blood glucose in mice," he said. "Klothos role in regulating the metabolic activity of the growth hormones is essential."

Dr. Kuro-o and his colleagues originally discovered the Klotho gene in 1997, naming it after one of the mythical Greek characters who controlled the length of human life.

The Klotho protein, which is found in several species, acts as a hormone in mice, circulating through the blood and binding to cells. Previous studies have shown that mutant mice lacking the Klotho gene appear normal until about a month of age, and then begin showing signs of age, such as skin atrophy, osteoporosis, arteriosclerosis and emphysema. The mice die prematurely at about two months.

Therapies based on Klotho could prove to be a way to
'"/>

Contact: Cliff Despres
cliff.despres@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
23-Apr-2007


Page: 1 2

Related biology news :

1. Climate change threatens wild relatives of key crops
2. A buffet for early human relatives
3. Sniffing out relatives, bluegill sunfish use self-referencing to recognize kin
4. The more alcoholic relatives a person has, the more they need to drink to feel alcohols effects
5. For diseases, when it comes to sharing a home, only close relatives will do
6. Researchers trace evolution to relatively simple genetic changes
7. Scientists find missing link between whale and its closest relative, the hippo
8. Human complexity and diversity spring from a surprisingly few (relatively speaking) genes
9. Lipoic acid explored as anti-aging compound
10. Researchers find new clues to biochemistry of anti-aging
11. Biomarkers may hone anti-aging therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... ... 2017 , ... For the second time in three years, ... Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, October 10th, ... mission is to change the trajectory of STEM education in America by dramatically ...
(Date:10/10/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... October 10, ... ... risk management, technological innovation and business process optimization firm for the life sciences ... the BoxWorks conference in San Francisco. , The presentation, “Automating GxP ...
(Date:10/9/2017)... ... , ... At its national board meeting in North Carolina, ARCS® Foundation ... of Physics and Astronomy, has been selected for membership in ARCS Alumni Hall ... 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of ...
Breaking Biology Technology:
Cached News: