HOME >> BIOLOGY >> NEWS
A single sugar found responsible for an antibody's ability to treat inflammation

For years, researchers have struggled to understand how IVIG worked. It's ability to treat autoimmune diseases seemed to bean apparent contradiction.

Intravenous immunoglobulin (IVIG) is a complex mixture of IgG antibodies made from human plasma that contains the pooled antibodies from thousands of people, and is only FDA-approved to treat a few assorted conditions; nonetheless, practitioners have used it off-label with varied success in patients with lupus, arthritis and asthma, among other autoimmune disorders. In the body, the antibodies in plasma act as part of the immune response to identify and deactivate foreign invaders. When they begin attacking the body's own cells, the same protective immunoglobulins (known as IgG antibodies) can cause autoimmune disorders like lupus, arthritis and asthma. And yet, when IVIG is infused into people with those exact autoimmune conditions, it calms inflammation rather than causes it.

Jeffery Ravetch, Theresa and Eugene M. Lang Professor and head of Rockefeller's Laboratory of Molecular Genetics and Immunology, was struck by this inconsistency. "If IgG triggers autoimmune disease, how could it be pathogenic and therapeutic?" he asked. "We call it the IgG paradox." Six years ago he started an investigation into exactly how IVIG worked, and what he's discovered could one day lead to a whole new class of therapeutics. In a paper published today in the journal Science, Ravetch and his colleagues, Falk Nimmerjahn and Yoshi Kaneko explain what makes IVIG effective: A small fraction of the IgG antibodies in the IVIG solution carry a sugar called sialic acid that is required for its protective ability.

IgG antibodies bind to and activate specific immune cells, with different forms or "subclasses" binding to specific receptors (called Fc receptors) on the immune cell's surface. Antibody subclasses have different abilities to induce inflammation in the body by virtue of their selective ability to engage ei
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
3-Aug-2006


Page: 1 2 3

Related biology news :

1. New research proves single origin of humans in Africa
2. 5 OHSU faculty members singled out for honors
3. TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
4. Caribbean frog populations started with single, ancient voyage on South American raft
5. Caribbean frogs started with a single, ancient voyage on a raft from South America
6. The social life of honeybees coordinated by a single gene
7. Penn researchers replace organ in adult mice using single-parent stem cells
8. Scripps research study reveals structural dynamics of single prion molecules
9. New nanotechnology able to examine single molecules, aiding in determining gene expression
10. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
11. Scientists discuss new frontiers in single-molecule research at American Chemical Society

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... , ... September 19, 2017 , ... ... largest group of funded early-stage tech companies. “Grit” author Angela Duckworth and her ... joining the ic@3401 community is Cooley, an international law firm with decades of ...
(Date:9/19/2017)... ... September 19, 2017 , ... Avomeen Analytical Services, an Ann ... 2017 Science Student Award. The scholarship program is dedicated to helping those who ... the costs of obtaining their science education. , Avomeen began the annual scholarship ...
(Date:9/18/2017)... ... September 18, 2017 , ... Scholarly publisher SPIE, ... SPIE Digital Library ( http://www.spiedigitallibrary.org ) on 15 August to a new and ... experience and incorporate a number of enhancements and new features, the website housing ...
(Date:9/14/2017)... (PRWEB) , ... September 14, ... ... Global Analytical Services, formally introduces its flexible scientist program (FSP)-- a flexible ... preferred-rate pricing. The FSP, which combines SSCI’s extensive project-based analytical and solid-state ...
Breaking Biology Technology:
Cached News: