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A stepwise retreat: How immune cells catch pathogens

To protect us from disease our immune system employs macrophages, cells that roam our body in search of disease-causing bacteria. With the help of long tentacle-like protrusions, macrophages can catch suspicious particles, pull them towards their cell bodies, internalise and destroy them. Using a special microscopy technique, researchers from the European Molecular Biology Laboratory (EMBL) now for the first time tracked the dynamic behaviour of these tentacles in three dimensions. In the current online issue of PNAS they describe a molecular mechanism that likely underlies the tentacle movement and that could influence the design of new nanotechnologies.

The long cell protrusions that macrophages use as tentacles to go fishing for pathogens are called filopodia. The internal scaffolds of these filopodia are long, dynamic filaments consisting of rows of proteins called actin. The filaments constantly grow and shrink by adding or removing individual actin building blocks. But the dynamic properties of the filopodia and the mechanical forces that they can apply are not fully understood. Using a special microscopy technique a team of researchers from the groups of Ernst Stelzer and Gareth Griffiths at EMBL could for the first time observe the tentacle dynamics in three dimensions and measure their properties to unprecedented detail.

The filopodia stretch out from the cell surface and upon contact with a suspicious particle they attach to it and immediately retract to pull the particle towards the cell body, says Holger Kress who carried out the research at EMBL and is now working at Yale University. We expected the tentacles to move in a continuous, smooth process, but surprisingly we observed discrete steps of filopodia retraction.

Highly precise measurements allowed the scientists for the first time to determine the speed and the force of the retraction and revealed that each individual retraction step is 36 nanometres long. These par
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Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
11-Jul-2007


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