HOME >> BIOLOGY >> NEWS
A study by the MUHC and McGill University opens a new door to understanding cancer

Montreal, 9 August 2007 - An in-depth understanding of the mechanisms that trigger cancer cell growth is vital to the development of more targeted treatments for the disease. An article published in the August 3 issue of Molecular Cell provides a key to these mechanisms that may prove crucial in the future. The paper is co-authored by Dr Morag Park, Director of the MUHC Molecular Oncology Group, and Dr Kalle Gehring, Head of the Nuclear Magnetic Resonnance Laboratory of the McGill University Biochemistry Department.

To understand cancer, it is necessary to first understand how the molecules interact, explains Dr. Park, who is also a Professor of oncology and biochemistry at McGill University. In that study we have clarified the structure of some of the proteins involved and their connections, which allows us to understand the consequences of these interactions. This is, in fact, a feat that merits close attention, because it means that researchers can now see elements smaller than a millionth of a millimetre!

In a cells interior, the function of the ubiquitin molecule is to clean house. It attaches itself to proteins that must disappear and triggers their degradation; in doing so, it allows a number of mechanisms to be minutely controlled. This new study reveals that ubiquitin also promotes interactions between proteins known as Cb-b. In a healthy patient, Cb-b is activated when a growth factor attaches itself to the surface of a cell, its role being to mitigate the cell proliferation and growth mechanisms induced by the factor. However, in some cancer patients this mitigation mechanism does not appear to function, partly because the ubiquitin does not attach itself correctly to the cell surface and to Cb-b. As a result, the effects of the growth factor become much more pronounced, which results in an unrestrained proliferation of cells that can become a cancer.

In the long term, this may serve as a basis for us to find ways to inte
'"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-934-1934
McGill University Health Centre
9-Aug-2007


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. New study suggests Concord grape juice may provide protection against breast cancer
5. Preclinical study links gene to brain aneurysm formation
6. In limiting life span, study finds booming bacteria innocent
7. Multicenter study nets new lung tumor-suppressor gene
8. MIT study: Maturity brings richer memories
9. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
10. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
11. New study demonstrates important role of glia in circadian timing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... 05, 2020 , ... Regenative Labs has received approval from the Centers for ... them the first Wharton’s jelly allografts to be assigned a Q code and be ... the first Wharton’s jelly allograft product to be recognized as a 361 HCT/P by ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... effectiveness of the Invictus Medical Neoasis™ active noise control device to attenuate typical ... that the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and ...
(Date:7/2/2020)... ... 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , a ... for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology Association ... of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 single ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... combine up to three different materials for use with CRM, neurostimulation, vascular, and ... three materials to meet specific design requirements, performance, and cost criteria; especially where ...
(Date:7/31/2020)... ... , ... eSource has long been touted as the solution to high data ... the reasons it did not take off as quickly as people initially expected, and ... moving towards capturing data electronically for clinical trials and then repurposing it for downstream ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July ... ... provider of cloud-based software for the life sciences industry, today announced the ... presentation platform designed specifically for Medical Science Liaisons (MSLs) and other field ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, the ... is only the beginning of a successful study, while protecting and accessing the catheter ... Global Head of Surgery from Envigo in a live webinar ...
Breaking Biology Technology:
Cached News: