HOME >> BIOLOGY >> NEWS
A study by the MUHC and McGill University opens a new door to understanding cancer

Montreal, 9 August 2007 - An in-depth understanding of the mechanisms that trigger cancer cell growth is vital to the development of more targeted treatments for the disease. An article published in the August 3 issue of Molecular Cell provides a key to these mechanisms that may prove crucial in the future. The paper is co-authored by Dr Morag Park, Director of the MUHC Molecular Oncology Group, and Dr Kalle Gehring, Head of the Nuclear Magnetic Resonnance Laboratory of the McGill University Biochemistry Department.

To understand cancer, it is necessary to first understand how the molecules interact, explains Dr. Park, who is also a Professor of oncology and biochemistry at McGill University. In that study we have clarified the structure of some of the proteins involved and their connections, which allows us to understand the consequences of these interactions. This is, in fact, a feat that merits close attention, because it means that researchers can now see elements smaller than a millionth of a millimetre!

In a cells interior, the function of the ubiquitin molecule is to clean house. It attaches itself to proteins that must disappear and triggers their degradation; in doing so, it allows a number of mechanisms to be minutely controlled. This new study reveals that ubiquitin also promotes interactions between proteins known as Cb-b. In a healthy patient, Cb-b is activated when a growth factor attaches itself to the surface of a cell, its role being to mitigate the cell proliferation and growth mechanisms induced by the factor. However, in some cancer patients this mitigation mechanism does not appear to function, partly because the ubiquitin does not attach itself correctly to the cell surface and to Cb-b. As a result, the effects of the growth factor become much more pronounced, which results in an unrestrained proliferation of cells that can become a cancer.

In the long term, this may serve as a basis for us to find ways to inte
'"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-934-1934
McGill University Health Centre
9-Aug-2007


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. New study suggests Concord grape juice may provide protection against breast cancer
5. Preclinical study links gene to brain aneurysm formation
6. In limiting life span, study finds booming bacteria innocent
7. Multicenter study nets new lung tumor-suppressor gene
8. MIT study: Maturity brings richer memories
9. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
10. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
11. New study demonstrates important role of glia in circadian timing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2019)... ... December 01, 2019 , ... Each year ... techniques to hit the life-science landscape. For more than a decade, our expert ... laboratories and facilitating biological discovery. This year’s crop of entries to The Scientist’s ...
(Date:11/27/2019)... ... , ... The MyOnyx rehab solution by Thought ... measure and display muscle activity in real time. This information helps the physical ... patient and therapist can see when exercises are performed correctly and efficiently. , ...
(Date:11/19/2019)... ... November 19, 2019 , ... Diagenode, Inc., ... Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader in life science ... offer Single-Cell ATAC-Seq (scATAC-Seq) Services, featuring Bio-Rad’s Droplet Digital PCR technology, to help ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... ... software solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies , ... Genedata Biologics® to streamline their R&D operations related to the ...
(Date:11/12/2019)... ... 12, 2019 , ... Bode Technology (Bode) , a ... Melinde Lutz Byrne, to the organization. Byrne’s team will strengthen efforts in expanding ... law enforcement through proven genealogy and DNA analysis methods. , Byrne’s hiring comes ...
(Date:11/9/2019)... ... November 08, 2019 , ... ... in pathology research, today announced the results of analyses examining the severity ... the phase 3 selonsertib studies (STELLAR). Strong correlations were demonstrated between AI-powered ...
(Date:11/6/2019)... ... 2019 , ... LeadingBiotech ,?an exclusive event series bringing ... East/West CEO conference to be held January 11-12, 2020 at the ... week of the J.P. Morgan Healthcare Conference and other biotech industry conferences, collectively ...
Breaking Biology Technology:
Cached News: