HOME >> BIOLOGY >> NEWS
A study by the MUHC and McGill University opens a new door to understanding cancer

Montreal, 9 August 2007 - An in-depth understanding of the mechanisms that trigger cancer cell growth is vital to the development of more targeted treatments for the disease. An article published in the August 3 issue of Molecular Cell provides a key to these mechanisms that may prove crucial in the future. The paper is co-authored by Dr Morag Park, Director of the MUHC Molecular Oncology Group, and Dr Kalle Gehring, Head of the Nuclear Magnetic Resonnance Laboratory of the McGill University Biochemistry Department.

To understand cancer, it is necessary to first understand how the molecules interact, explains Dr. Park, who is also a Professor of oncology and biochemistry at McGill University. In that study we have clarified the structure of some of the proteins involved and their connections, which allows us to understand the consequences of these interactions. This is, in fact, a feat that merits close attention, because it means that researchers can now see elements smaller than a millionth of a millimetre!

In a cells interior, the function of the ubiquitin molecule is to clean house. It attaches itself to proteins that must disappear and triggers their degradation; in doing so, it allows a number of mechanisms to be minutely controlled. This new study reveals that ubiquitin also promotes interactions between proteins known as Cb-b. In a healthy patient, Cb-b is activated when a growth factor attaches itself to the surface of a cell, its role being to mitigate the cell proliferation and growth mechanisms induced by the factor. However, in some cancer patients this mitigation mechanism does not appear to function, partly because the ubiquitin does not attach itself correctly to the cell surface and to Cb-b. As a result, the effects of the growth factor become much more pronounced, which results in an unrestrained proliferation of cells that can become a cancer.

In the long term, this may serve as a basis for us to find ways to inte
'"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-934-1934
McGill University Health Centre
9-Aug-2007


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. New study suggests Concord grape juice may provide protection against breast cancer
5. Preclinical study links gene to brain aneurysm formation
6. In limiting life span, study finds booming bacteria innocent
7. Multicenter study nets new lung tumor-suppressor gene
8. MIT study: Maturity brings richer memories
9. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
10. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
11. New study demonstrates important role of glia in circadian timing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2019)... ... 2019 , ... Catalent Pharma Solutions, the leading global provider ... products, today announced that it will host a roundtable session at the World ... Hill, Maryland, on April 10-12, 2019. , On Thursday, April 11 at 3:30 ...
(Date:4/1/2019)... ... April 01, 2019 , ... ... Characterizing Skin Related Conditions” by the US Patent and Trademark Office on January ... an invention by uBiome collaborators Dr. Zachary Apte, Dr. Daniel Almonacid, Dr. ...
(Date:3/29/2019)... ... March 29, 2019 , ... RoosterBio, Inc, ... attend the Society for Biomaterials Annual Meeting & Exposition on April 3-6, 2019 ... with academic, healthcare, governmental and business professionals in all aspects of the biomaterial ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... 19, 2019 , ... The AACR annual conference pulls together a diverse group ... cutting-edge cancer research. The Visikol team will be at the show at booth #3252 ... well as their digital pathology services . “For AACR this year we are ...
(Date:3/19/2019)... (PRWEB) , ... March 19, 2019 , ... Bogey was nine years old when he ... in his left hip. These ailments caused Bogey to experience problems with his mobility. ... up stairs, and onto his special spot on the couch. , His owners, devastated at ...
(Date:3/19/2019)... ... ... will review strategies for data management in modular and adaptive clinical trials. , Participants ... to 30 percent, reducing cost while increasing quality, achieving clinical site set-up faster , ... – reducing risk and impact on trial success, trial teams, and trial execution , ...
(Date:3/19/2019)... ... March 19, 2019 , ... Cirrascale Cloud Services ®, ... begun offering NVIDIA® DGX-1™ deep learning systems as part of its dedicated, multi-GPU ... highest performance for artificial intelligence and deep learning research and development. , “Our ...
Breaking Biology Technology:
Cached News: