HOME >> BIOLOGY >> NEWS
A sweet solution for Alzheimer's disease?

Certain variants of a simple sugar ameliorate Alzheimer's-like disease in mice, according to a new study by Canadian researchers. Although the new studies are still in the early stages, the findings could lead to new therapies that prevent or delay the onset of Alzheimer's disease.

The new studies show that some types of a sugar called cyclohexanehexol--also known as inositol--prevented the accumulation of amyloid deposits, a hallmark of Alzheimer's disease. Scyllo-inositol treatment also improved cognitive abilities in the mice and allowed them to live a normal lifetime. The study appeared in advance online publication of the journal Nature Medicine on June 11, 2006.

HHMI international research scholar and senior author Peter St George-Hyslop cautioned that the chemicals tested in these studies are not the type of inositol sold commercially as a nutritional supplement. That type--myo-inositol--has been shown previously to be ineffective at breaking up amyloid aggregates, he said.

In the brain of a person with Alzheimer's disease, small proteins called amyloid aggregate into plaques, and a protein called tau clumps into neurofibrillary tangles. The brain becomes inflamed and neurons atrophy and die. It's not completely clear what kind of amyloid peptide (monomers, oligomeric aggregates, or fibrillar aggregates) is responsible for the onset of disease, said St George-Hyslop of the University of Toronto. "Because we were able to show that scyllo-inositol specifically dispersed the high-molecular-weight oligomeric aggregates, this study confirms that the initiating event is the accumulation of oligomeric aggregates of amyloid peptide," he said.

Previous work by JoAnne McLaurin, also of the University of Toronto and lead author of the Nature Medicine paper, showed that several types of inositol could stop amyloid proteins from aggregating in test tubes. To see if these compounds could do the same in living animals, St George-Hyslop, M
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
12-Jun-2006


Page: 1 2 3

Related biology news :

1. Native fruits bear sweet antioxidants
2. Study shows cane sugar, corn sweeteners have similar effects on appetite
3. Study finds Western-style meat-sweet diet increases risk of breast cancer in postmenopausal women
4. Insights into honey bee sex gene could bring sweet success in breeding
5. Uncovering DNAs sweet secret
6. The sweet science: Viruses switch grip to gain upper hand
7. UW-Madison researchers find new way to sweeten key drugs
8. Attacking cancers sweet tooth is effective strategy against tumors
9. Sweet water taste paradoxically predicts sweet taste inhibitors
10. Birdsong sounds sweeter because throats filter out messy overtones
11. How sweet it isnt -- preference for alternatives to sugar based on sour, bitter tastes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: