HOME >> BIOLOGY >> NEWS
A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells

s to global DNA methylation and histone methylation patterns. In addition, female-induced stem cells showed reactivation of the X chromosome that was silenced in differentiated cells and exhibited random X inactivation upon differentiation.

Our results demonstrate that the ectopic expression of four transcription factors is sufficient to globally reset the epigenetic landscape of fibroblasts into that of pluripotent cells that are remarkably similar to embryonic stem cells, explains Dr. Hochedlinger. Dr. Plath adds The fact that our induced pluripotent cells are epigenetically similar to ES cells suggests that epigenetic abnormalities will not pose a problem for the potential therapeutic applications of induced pluripotent cells. The researchers went on to show that the induced pluripotent cells could differentiate into numerous cell types, including blood cells in culture and oocytes in animals. Importantly, two related papers being published in the journal Nature demonstrate that similar induced pluripotent cells can also give rise to fertilized embryos and viable offspring, respectively. Future studies are needed to examine whether direct reprogramming of human cells follows these promising patterns observed in mice.

These studies and other recent advances in strategies aimed at generating patient-specific stem cell lines are discussed in the review article by Dr. Shinya Yamanaka in the current issue of Cell Stem Cell.


'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
6-Jun-2007


Page: 1 2

Related biology news :

1. DNA gets new twist: Carnegie Mellon scientists develop unique DNA nanotags
2. Human and chimp genomes reveal new twist on origin of species
3. A new twist on power walking
4. Physics team puts new twist on spin hall effect
5. Protein transformation gives new twist to medical research
6. Reprogrammed fibroblasts identical to embryonic stem cells
7. Orangutans communication resembles a game of charades
8. Mouse FH knockout resembles human renal cell cancer
9. Self-assembling nano-ice discovered at UNL -- Structure resembles DNA
10. The structure of a virus infecting bacteria resembles a human virus
11. Dragonfly migration resembles that of birds, scientists say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and ... Labs ), Inc. has been selected for membership in ARCS Alumni Hall ...
(Date:10/11/2017)... Md. (PRWEB) , ... October 11, 2017 , ... ... digital pathology, announced today it will be hosting a Webinar titled, “Pathology is ... Advanced Pathology Associates , on digital pathology adoption best practices and how Proscia ...
(Date:10/11/2017)... ... October 11, 2017 , ... A ... pregnancy rates in frozen and fresh in vitro fertilization (IVF) transfer ... age to IVF success. , After comparing the results from the fresh and ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
Breaking Biology Technology:
Cached News: