A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells

s to global DNA methylation and histone methylation patterns. In addition, female-induced stem cells showed reactivation of the X chromosome that was silenced in differentiated cells and exhibited random X inactivation upon differentiation.

Our results demonstrate that the ectopic expression of four transcription factors is sufficient to globally reset the epigenetic landscape of fibroblasts into that of pluripotent cells that are remarkably similar to embryonic stem cells, explains Dr. Hochedlinger. Dr. Plath adds The fact that our induced pluripotent cells are epigenetically similar to ES cells suggests that epigenetic abnormalities will not pose a problem for the potential therapeutic applications of induced pluripotent cells. The researchers went on to show that the induced pluripotent cells could differentiate into numerous cell types, including blood cells in culture and oocytes in animals. Importantly, two related papers being published in the journal Nature demonstrate that similar induced pluripotent cells can also give rise to fertilized embryos and viable offspring, respectively. Future studies are needed to examine whether direct reprogramming of human cells follows these promising patterns observed in mice.

These studies and other recent advances in strategies aimed at generating patient-specific stem cell lines are discussed in the review article by Dr. Shinya Yamanaka in the current issue of Cell Stem Cell.


Contact: Erin Doonan
Cell Press

Page: 1 2

Related biology news :

1. DNA gets new twist: Carnegie Mellon scientists develop unique DNA nanotags
2. Human and chimp genomes reveal new twist on origin of species
3. A new twist on power walking
4. Physics team puts new twist on spin hall effect
5. Protein transformation gives new twist to medical research
6. Reprogrammed fibroblasts identical to embryonic stem cells
7. Orangutans communication resembles a game of charades
8. Mouse FH knockout resembles human renal cell cancer
9. Self-assembling nano-ice discovered at UNL -- Structure resembles DNA
10. The structure of a virus infecting bacteria resembles a human virus
11. Dragonfly migration resembles that of birds, scientists say

Post Your Comments:

(Date:11/17/2015)... PARIS , November 17, 2015 ... November 2015.   --> Paris from ... --> DERMALOG, the biometrics innovation leader, has invented the ... and fingerprints on the same scanning surface. Until now two ... fingerprints. Now one scanner can capture both on the same ...
(Date:11/17/2015)... Nov. 17, 2015  Vigilant Solutions announces today that ... Board of Directors. --> ... retiring from the partnership at TPG Capital, one of ... over $140 Billion in revenue.  He founded and led ... the TPG companies, from 1997 to 2013.  In his ...
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced expansion of its TDDI ... touch controller and display driver integration (TDDI) ... smartphones. These new TDDI products add to the ... resolution), TD4302 (WQHD resolution), and TD4322 (FHD resolution) ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh ... Insertion points for in-line sensors can represent a weak spot where leaking process ... series of retractable sensor housings , which are designed to tolerate extreme process ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 list ... facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds up ...
(Date:11/24/2015)... ANGELES , Nov. 24, 2015 ... biotechnology company focused on the discovery, development and commercialization ... , Ph.D., Chief Executive Officer, is scheduled to present ... 1, 2015 at 10:50 a.m. EST, at The Lotte ... City . http://capricor.com/news/events/ . ...
(Date:11/24/2015)... 24, 2015  PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI ... company,s president and chief executive officer, will present at the ... in New York City . The presentation ... 1, 2015 at 9:30 a.m. EST. http://www.pdl.com ... website at least 15 minutes prior to the presentation to ...
Breaking Biology Technology:
Cached News: