Wafik El-Deiry, M.D., Ph.D., University of Pennsylvania, "Novel Therapy for Resistant Metastatic Colon Cancer." The goals are to define the mechanisms in colon cancer that make tumor cells resistant to apoptosis, and develop combination drug therapies that can reverse the apoptotic defect.
Edgar G. Engelman, M.D., Stanford University, "T-Cell Signaling in Metastatic Colon Cancer." This study will examine the failure of the immune system to detect colon cancer cells with the goal of identifying and profiling tumor-associated signaling abnormalities in T-cells. This will affect choice of therapy and will show whether signalling abnormalities can be reversed using immunotherapy.
Douglas V. Faller, M.D., Ph.D., Boston University School of Medicine, "PKC-Delta as a Therapeutic Target in Colon Cancer." The approach is to inhibit PKC-delta which is not critical for normal cellular growth but which, in tumor cells, inhibits Ras-mediated apoptosis. Molecular strategies will identify more active and more specific inducers of the Ras-mediated apoptotic pathway.
Robert D. Ladner, Ph.D., University of Southern California, "Histone Deacetylase Inhibitors for the Treatment of Metastatic Colon Cancer." New approaches will be developed to enhance the effectiveness of 5FU using histone de-acetylase inhibitors.
Eric Lagasse, Ph.D., PharmD, University of Pittsburgh, "Metastatic Colon Cancer, Stem Cells and Bioreactors." Using an artificial bioreactor that models the environment in liver and colon cancer, stem cells will be identified and expanded in vitro. Therapy will then be refined and customized preclinically before being administered to patients.
Nouri Neamati, Ph.D., University of Southern California, "Precli