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AACR awards $2.6 million in grants for metastatic colon cancer research

nical Development of SC144 in Metastatic Colon Cancer." A new agent, SC144 has been shown to cause up-regulation of IL24 - a very potent anticancer protein. SC144 will be fully evaluated in mouse models and then, potentially, trials will be extended to humans.

  • Boris C. Pasche, M.D., Ph.D., Northwestern University, "Targeting the TGFBR1*6A in Metastatic Colon Cancer." This study will use antibodies to TGFB and assess their effects on colon tumor growth in mice. A humanized antibody will be used in a Phase I/II clinical trial.

  • Gary K. Schwartz, M.D., Memorial Sloan Kettering Cancer Center, "Targeting the Notch Signaling Pathway in Metastatic Colon Cancer." The effectiveness of combining notch and ras inhibitors such as gamma secretase inhibitors will be examined in colon cancer cells as a prerequisite to designing a Phase I clinical trial.

  • Oliver Stoeltzing, M.D., Universitaet Regensburg, "The Role of Hsp 90 in Hepatic Growth of Colorectal Cancer Metastases." Using colon cell lines and xenografts, this study will examine the role of tissue hypoxia in colorectal hepatic metastases and the suitability of targeting Hsp 90 for molecular targeted therapies.


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Contact: Staci Vernick Goldberg
goldberg@aacr.org
215-440-9300
American Association for Cancer Research
7-Jul-2006


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