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ACS News Service Weekly PressPac -- August 2, 2006

bitors of amyloid beta. The new screening method does not require synthetic amyloid beta, according to a report on the research scheduled for the Aug. 22 issue of ACS Chemical Biology.

Hecht and Chang describe the method as rapid, inexpensive and suitable for use in screening large numbers of compounds for amyloid beta inhibitors. They also describe its use in isolating new inhibitors.

ARTICLE #4
"A High Throughput Screen for Compounds that Inhibit Aggregation of the Alzheimer's Peptide"

FOR FULL TEXT, CONTACT:
Michael Bernstein
ACS News Service
Phone: 202-872-4400
Fax: 202-872-4370

CONTACT:
Michael H. Hecht, Ph.D.
Princeton University
Phone: 609-258-2901
Fax: 609-258-6746
Email: hecht@princeton.edu

Young-Tae Chang, Ph.D.
New York University
Phone: 212-998-8491
Fax: 202-260-7905
Email: yt.chang@nyu.edu

ARTICLE #5 EMBARGOED FOR RELEASE AT 9 A.M., AUG. 7, 2006
Beyond Herceptin: Toward a potential new generation of better cancer drugs

Chemical & Engineering News

The striking success of Herceptin in treating breast cancer has sparked an intensive effort by pharmaceutical companies to develop other cancer drugs that target the same biochemical pathway in different and potentially more effective ways, according to an article scheduled for the Aug. 7 edition of Chemical & Engineering News, the ACS' weekly newsmagazine.

Written by C&EN associate editor Lisa Jarvis, the article points out that the new compounds also could be more convenient for patients. Herceptin is a protein-based drug that blocks the action of a growth factor important in about 25 percent of breast cancer patients. As a protein, Herceptin must be given intravenously. The new compounds are not proteins and could be taken by mouth.

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Contact: Michael Bernstein
m_bernstein@acs.org
202-872-4400
American Chemical Society
7-Aug-2006


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