ACS News Service Weekly PressPac -- Feb. 21, 2007



Kazunori Koide, Ph.D.
University of Pittsburgh
Pittsburgh, Pennsylvania 15260
Telephone: 412-624-8767
Fax: 412-624-8611
Email: koide@pitt.edu


A new target in the war on cancer
Chemical & Engineering News

A new family of potential anti-cancer drugs is quietly causing excitement in the pharmaceutical industry as early data from clinical trials shows promising responses in patients, according to an article scheduled for the Feb. 26 issue of Chemical & Engineering News (C&EN), the ACS' weekly newsmagazine.

In the article, C&EN associate editor Lisa Jarvis explains that the new compounds may circumvent the long-standing problem of drug resistance, in which anti-cancer drugs gradually loose their effectiveness. The drugs focus on a new target in the war against cancer a substance called heat shock protein 90 (Hsp90). Heat shock proteins are most active when the cell is exposed to elevated temperatures, infection, inflammation, toxins and other stresses that can cause a protein to unfold. Like housekeepers, heat shock proteins help those proteins including mutated, cancer-causing proteins get back into their proper shape.

When Hsp90's effects are blocked in cancer cells, those cancer-causing proteins cannot survive, potentially stopping the disease in its track. When Hsp90's effects are blocked in cancer cells, damaged proteins accumulate, and the cell dies. Jarvis explains that cancer cells, with their horribly mutated proteins, seem to be especially dependent on Hsp90, and more vulnerable than other body cells when Hsp90's effects are blocked.

Contact: Michael Woods
American Chemical Society

Page: 1 2 3 4 5 6 7 8 9

Related biology news :

1. ACS News Service Weekly PressPac -- May 23, 2007
2. ACS News Service Weekly PressPac -- May 16, 2007
3. ACS News Service Weekly PressPac -- May 9, 2007
4. ACS News Service Weekly PressPac -- May 2, 2007
5. ACS News Service Weekly PressPac -- April 25, 2007
6. ACS News Service Weekly PressPac -- April 18, 2007
7. ACS News Service Weekly PressPac -- April 11, 2007
8. ACS News Service Weekly PressPac -- March 28, 2007
9. ACS News Service Weekly PressPac -- March 21, 2007
10. ACS News Service Weekly PressPac -- March. 14, 2007
11. ACS News Service Weekly PressPac -- February 14, 2007

Post Your Comments:

(Date:6/5/2020)... , ... June 04, 2020 , ... Greffex, a pioneering ... its Board of Directors. , “Neil understands the need for a global perspective to ... and CEO of Greffex. Mr. Bush will serve as an independent, director of the ...
(Date:5/30/2020)... ... May 29, 2020 , ... eInfochips, ... enterprises globally, has collaborated with EchoNous Inc. to develop the cloud-based connected health ... systolic heart function, which has been clinically tested versus expert measurements, yielding improved ...
(Date:5/28/2020)... , ... May 27, 2020 , ... ... Workforce Advisor™ , a solution that uniquely combines lab testing insights and ... employers systematically support the ongoing health and safety of employees returning to the ...
Breaking Biology News(10 mins):
(Date:6/11/2020)... ... June 08, 2020 , ... Greffex, a leading genetic engineering ... proprietary clean viral vectors, recently announced a key manufacturing agreement with FUJIFILM Diosynth ... the world’s most successful gene therapy delivery vehicle (vector) with broad applications for ...
(Date:6/11/2020)... ... June 09, 2020 , ... Reducing carbon emissions has been and will ... Agreement to stock market dips, ways to reduce CO2 is something we can’t avoid. ... Most of the biofuels being produced today are created from recycled cooking oil or ...
(Date:5/30/2020)... ... 29, 2020 , ... Medrio, Inc., the leading provider of ... enabled Cytovale, Inc., a medical technology company dedicated to revolutionizing diagnostics for conditions ... patient in (FPI) in just seven days. The Cytovale technology will allow patients ...
(Date:5/28/2020)... ... 2020 , ... The Security Industry Association (SIA) and SecureIDNews ... the Women in Biometrics Awards – a globally recognized program co-founded by ... and the SIA Women in Security Forum . The honorees will be recognized ...
Breaking Biology Technology:
Cached News: